Distributed Full-duplex via Wireless Side Channels: Bounds and Protocols

In this paper, we study a three-node full-duplex network, where a base station is engaged in simultaneous up- and downlink communication in the same frequency band with two half-duplex mobile nodes. To reduce the impact of inter- node interference between the two mobile nodes on the system capacity, we study how an orthogonal side-channel between the two mobile nodes can be leveraged to achieve full-duplex-like multiplexing gains. We propose and characterize the achievable rates of four distributed full-duplex schemes, labeled bin-and- cancel, compress-and-cancel, estimate-and-cancel and decode- and-cancel. Of the four, bin-and-cancel is shown to achieve within 1 bit/s/Hz of the capacity region for all values of channel parameters. In contrast, the other three schemes achieve the near-optimal performance only in certain regimes of channel values. Asymptotic multiplexing gains of all proposed schemes are derived to show that the side-channel is extremely effective in regimes where inter-node interference has the highest impact.Comment: Published in IEEE Transactions on Wireless Communications, August 201

Distributed Full-duplex via Wireless Side Channels: Bounds and Protocols

In this thesis, we study a three-node full-duplex network, where the infrastructure node has simultaneous up- and downlink communication in the same frequency band with two half-duplex nodes. In addition to self-interference at the full-duplex infrastructure node, the three-node network has to contend with the inter-node interference between the two half-duplex nodes. The two forms of interferences differ in one important aspect that the self-interference is known at the interfered receiver. Therefore, we propose to leverage a wireless side-channel to manage the inter-node interference. We characterize the impact of inter-node interference on the network achievable rate region with and without a side-channel between the nodes. We present four distributed full-duplex inter-node interference cancellation schemes, which leverage the device-to-device wireless side-channel for improved interference cancellation. Of the four, bin-and-cancel is asymptotically optimal in high signal-to-noise ratio limit which uses Han-Kobayashi common-private message splitting and achieves within 1 bits/s/Hz of the capacity region for all values of channel parameters. The other three schemes are simpler compared to bin-and-cancel but achieve the near-optimal performance only in certain regimes of channel values. Asymptotic multiplexing gains of all proposed schemes are derived to show analytically that leveraging the side channel can be highly beneficial in increasing the multiplexing gain of the system exactly in those regimes where inter-node interference has the highest impact

Constructive Relay based Cooperative Routing in Mobile Ad hoc Networks

PhDMobile Ad hoc networks (MANETs) are flexible networks that transmit packets node-by-node along a route connecting a given source and destination. Frequent link breaks (due to node mobility) and quick exhaustion of energy (due to limited battery capacity) are two major problems impacting on the flexibility of MANETs. Cooperative communication is a key concept for improving the system lifetime and robustness and has attracted considerable attention. As a result, there is much published research concerning how to utilize cooperative communication in a MANET context. In the past few years, most cooperative technologies have focused on lower layer enhancements, such as with the Physical Layer and MAC Layer, and have become very mature. At the Network Layer, although some research has been proposed, issues still remain such as the lack of a systematically designed cooperative routing scheme (including route discovery, route reply, route enhancement and cooperative data forwarding), the use of cooperative communication for mobility resilience, and route selection (jointly considering the energy consumption, energy harvesting potential and link break probability). Driven by the above concerns, a novel Constructive Relay based CooPerative Routing (CRCPR) protocol based on a cross-layer design is proposed in this thesis. In CRCPR, we fi rst modify the traditional hello message format to carry some additional neighbour information. Based on this information, a key aspect of this protocol is to construct one or more small rhombus topologies within the MANET structure, which are stored and maintained in a COoPerative (COP) Table and Relay Table. Next, the route request procedure is re-designed to improve resilience to node mobility with a scheme called Last hop Replacement. Finally, assuming nodes are mostly battery-powered, destination node based route-decision criteria are explored that can consider energy consumption, energy harvesting and link break probability to determine an appropriate route across the MANET. As the hello message format is modi ed to carry additional information, the control overhead is increased. However, in order to improve the control message eficiency, a new generalised hello message broadcasting scheme entitled Adjust Classi ed Hello Scheme is developed, which can be deployed onto every routing protocol employing a hello mechanism. As well as designing a new routing protocol for MANETs, including route discovery, route selection, route reply, route maintenance, route enhancement and cooperative data forwarding, the proposed scheme is implemented within an Opnetbased simulation environment and evaluated under a variety of realistic conditions. The results con rm that CRCPR improves mobility resilience, saves energy via cooperative communication and reduces the control overhead associated with the hello message mechanism.Chinese Scholarship Counci

PD-L1 aptamer-functionalized degradable hafnium oxide nanoparticles for near infrared-II diagnostic imaging and radiosensitization

Immune checkpoint blockade is now recognized as a paradigm-shifting cancer therapeutic strategy, whereas there remains difficulty in accurately predicting immunotherapy efficacy by PD-L1 expression. In addition, radiotherapy for cancer patients faces the problem of insufficient dose of radiotherapy at the tumor site while which have been not tolerated by normal tissues. In this study, we created PD-L1 aptamer-anchored spherical nucleic acids (SNAs) with a shell made of PD-L1 aptamer and indocyanine green (ICG) embedded in a mesoporous hafnium oxide nanoparticle core (Hf@ICG-Apt). Upon low pH irradiation in the tumor sites, the nano-system enabled the release of ICG in the high PD-L1 expression tumor to develop a high tumor-to-background ratio of 7.97 ± 0.76 and enhanced the ICG tumor retention to more than 48 h. Moreover, Hf@ICG-Apt improved radiation therapy (RT) when combined with radiation. Notably, Hf@ICG-Apt showed scarcely any systemic toxicity in vivo. Overall, this research offered a novel approach for applying reliable monitoring of PD-L1 expression and localization and robust RT sensitization against cancer with good biosafety

LFQ-Based Peptide and Protein Intensity Differential Expression Analysis

Testing for significant differences in quantities at the protein level is a common goal of many LFQ-based mass spectrometry proteomics experiments. Starting from a table of protein and/or peptide quantities from a given proteomics quantification software, many tools and R packages exist to perform the final tasks of imputation, summarization, normalization, and statistical testing. To evaluate the effects of packages and settings in their substeps on the final list of significant proteins, we studied several packages on three public data sets with known expected protein fold changes. We found that the results between packages and even across different parameters of the same package can vary significantly. In addition to usability aspects and feature/compatibility lists of different packages, this paper highlights sensitivity and specificity trade-offs that come with specific packages and settings

Sub-MIC Tylosin Inhibits Streptococcus suis Biofilm Formation and Results in Differential Protein Expression

Streptococcus suis (S. suis) is a crucial zoonotic pathogen which causes severe diseases in humans and pigs. Biofilms of S. suis can induce persistent infections which are harder to treat. Sub-minimal inhibitory concentration (sub-MIC) of tylosin can inhibit biofilm formation in bacteria. By using iTRAQ strategy, we compared the protein expression profiles of S. suis grown with sub-MIC tylosin treatment or no treatement. The result showed that 96 proteins expression were changed with 77 up-regulated and 19 down-regulated proteins. Several metabolism proteins (such as phosphoglycerate kinase), as well as cell surface proteins (such as ABC transporter proteins), were found to be involved in biofilm formation. Overall, our results indicated that S. suis metabolic regulation, cell surface proteins, and virulence proteins appear to be of importance in biofilm growth by sub-MIC tylosin treated. Thus, our data analyzed rough regulation of biofilm formation that lay the foundation for the future research of mechanism and targets