Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis

Background: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder with complex pathogenesis and metabolic complications, such as insulin resistance. Among the new markers, preptin seems to play a significant role in metabolic disorders. Objective: This meta-analysis was conducted to determine the relationship between circulating preptin levels and PCOS. Materials and Methods: A systematic review and meta-analysis was performed to identify relevant articles in electronic databases such as PubMed, Web of Science, Scopus, Cochrane, EMBASE, and the Google Scholar search engine, using a predefined search strategy. A random-effects model was used to combine standard mean difference (SMD) and 95% CI to compare results between groups. Metaregression and subgroup analysis were also performed to reveal the sources of heterogeneity. Results: The meta-analysis encompassed a total of 8 studies and 582 participants. The results indicate a statistically significant association between PCOS and serum preptin levels, with a pooled standardized mean difference (SMD = 1.35; 95% CI: 0.63- 2.08; p < 0.001). Further analysis suggested a significant difference in serum preptin levels between women with PCOS and higher homeostatic model assessment for insulin resistance ratio (SMD = 2.40; 95% [CI]: 1.17-3.63; p < 0.001) within the subgroup. Conclusion: Our meta-analysis shows that increased serum preptin levels are associated with PCOS, suggesting that preptin may be related to the pathogenesis of PCOS and may be recognized as a novel diagnostic biomarker for PCOS. However, further studies are needed to confirm our results. Key words: Polycystic ovary syndrome, Proinsulin-like growth factor II, Preptin, Meta-analysis

Circulating nesfatin-1 levels in women with polycystic ovary syndrome: A systematic review and meta-analysis

Background: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in females. Nesfatin-1 is a neuropeptide synthesized in the hypothalamus and other peripheral organs, and there are conflicting opinions about its correlation with PCOS. Objective: This study aims to investigate the correlation between nesfatin-1 and PCOS and evaluates the effectiveness of nesfatin-1 as a biomarker for the detection of PCOS in women. Materials and Methods: A systematic review and meta-analysis were conducted to identify pertinent articles from databases such as PubMed, Web of Science, Cochrane, EMBASE, Scopus, and Google Scholar. The standardized mean difference (SMD) and 95% confidence interval (CI) were calculated using a random effects model to compare group outcomes. Additionally, meta-regression and subgroup analysis were performed to elucidate sources of heterogeneity. Results: The meta-analysis involved 12 studies with 1222 participants, and the findings revealed a significant relationship between PCOS and nesfatin-1 levels. The pooled (SMD = 0.54; 95% CI: 0.00-1.07; p = 0.04) indicated a significant difference between the evaluated groups. Moreover, a subgroup analysis showed that there was a substantial difference in nesfatin-1 levels among women with PCOS and higher homeostatic model assessment for insulin resistance ratio (SMD = 1.46; 95% CI: 0.92-2.00; p < 0.001). Conclusion: Our meta-analysis indicates an association between high nesfatin-1 levels and PCOS. This suggests a potential role of nesfatin-1 in the development of PCOS and proposes it as a potential diagnostic biomarker for the disease. However, further research is necessary to validate these findings. Key words: Polycystic ovary syndrome, Insulin resistance, Body mass index, Meta-analysis

Association between hypothyroidism and sperm quality parameter dataset

Subclinical hypothyroidism (SCH) has been recognized as a common endocrine disorder with potential impacts on reproductive health.</p

Prevalence of autoimmune thyroiditis in women with polycystic ovary syndrome: a systematic review and meta-analysis

Introduction: Polycystic ovary syndrome (PCOS) is one of the women's most common endocrine disorders, which may be is associated with some autoimmune diseases such as autoimmune thyroiditis disorders (AIT). This study was performed with aim to evaluate the prevalence of autoimmune thyroiditis in women with PCOS by a systematic review and meta-analysis.  Methods: This review study was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. The research documents were collected by searching Persian-language databases such as Magiran, Sid, Iranmedex, and English-language databases such as Web of Science, Pubmed Scopus, and Google Scholar from January 1 until August 1, 2022. All studies were evaluated by the Newcastle-Ottawa scale at the four levels of selection, comparison, exposure, and outcome. Data analysis was performed with comprehensive meta-analysis (CMA) software (version 3.1).  Results: A total of 9 studies with 2290 participants were included in the meta-analysis. The prevalence of AIT in patients with polycystic ovary syndrome was 26.4% (95% CI: 21.3-32.2) and in healthy women was 11.7% (95% CI: 8.1-16.7). Subgroup studies demonstrated a higher prevalence of AIT in younger patients. Meta-regression analysis also showed a significant association between the study area and the prevalence of AIT.  Conclusion: There is a significant association between the increased prevalence of AIT in patients with PCOS. This shows the importance of evaluating and monitoring thyroid function in patients with PCOS