Music Enhances Brain Development in Premature Infants: A literature Review

Preterm infants have a high risk of neurodevelopmental problem with a decrease of functional capacity of brain network. Without early intervention, it will develop as long-lasting brain network deficiency. We examine the studies of music effect on early life of preterm infants in neonatal intensive care units (NICU). It founds that music has a positive correlation with brain development in preterm infants. The preterm infants exposed with repetitive music as NICU environment enrichment have a chance to develop brain as good as the term infants and have long-lasting beneficial effects on brain development

CRISPR-Cas9 through AAV delivery system as a gene therapy in Parkinson’s disease

The global population living with Parkinson’s disease is estimated to reach 9.4 million people, which has increased significantly since 2016, with a total of 6 million people. Parkinson's is a neurodegenerative disease of the substantia nigra that causes a decrease in dopamine production and is characterized by the appearance of cytoplasmic misfold proteins called Lewy bodies. The study found that abnormalities or mutations in the SNCA and LRRK2 genes correlated with the overproduction of the ɑ-synuclein protein, which forms Lewy bodies that cause Parkinson's. Current Parkinson's medications only temporarily replace lost dopamine but do not treat the direct cause of Parkinson's; this research used qualitative literature study with content analysis, observation, and development; the use of CRISPR-Cas9 through AAV genetic engineering in repairing SNCA and LRRK2 mutant gene. This genetic therapy works by cutting the mutant DNA base sequences in the SNCA and LRRK2 genes and then replacing them with normal sequences through a homology-direct repair mechanism. As a result, the abnormalities or mutations that cause Parkinson's in these two genes can be corrected, so that dopaminergic levels in the brain can return to normal and excessive accumulation of α-synuclein protein can be suppressed

Music Enhances Brain Development in Premature Infants: A literature Review

Abstract Preterm infants have a high risk of neurodevelopmental problem with a decrease of functional capacity of brain network. Without early intervention, it will develop as long-lasting brain network deficiency. We examine the studies of music effect on early life of preterm infants in neonatal intensive care units (NICU). It founds that music has a positive correlation with brain development in preterm infants. The preterm infants exposed with repetitive music as NICU environment enrichment have a chance to develop brain as good as the term infants and have long-lasting beneficial effects on brain development