Influence of an organic acid blend and essential oil blend, individually or in combination, on growth performance, carcass parameters, apparent digestibility, intestinal microflora and intestinal morphology of broilers

WOS: 000375416900012PubMed ID: 267851401. This study aimed to evaluate the influence of an organic acid (OA) and essential oil (EO) blends, individually or in combination, on growth performance, carcass parameters, apparent digestibility, intestinal microflora and intestinal morphology of broilers. 2. A total of 480 one-d-old male Ross 308 chicks were randomly assigned to 4 treatments consisting of 4 replicates each (n = 30 birds in each replicate). Dietary treatments consisted of a basal diet (control), and basal diet supplemented with 2 g/kg OA blend (OAB), 300 mg/kg EO blend (EOB), or with 2 g/kg OA and 300 mg/kg EO blend (OAB-EOB) for 42 d. 3. The dietary supplementation with EO blend or in combination with OA blend increased body weight gain and improved feed efficiency as compared to control. Dietary treatments had no significant effects on feed consumption or relative organ weights of broilers. 4. The OAB diet increased carcass yield compared to the control diet but the lowest carcass yield occurred with the OAB-EOB combination. Birds fed on EOB and OAB-EOB diets had lower ileum Escherichia coli counts than birds fed on the control diet. 5. There was no significant effect of treatments on apparent digestibility at 16-21 d but the EOB and OAB-EOB diets increased apparent digestibility of dry matter and crude protein during the finisher period (d 37-42) compared to the control diet. 6. Birds fed on the EOB and OAB-EOB diets had greater villus height in the ileum at 21 and 42 d of age and had lower crypt depth in the ileum at 42 d of age than birds given the control diet. 7. In conclusion, beneficial effects of the use of EO blend individually or in combination with the OA blend were observed but the OA blend alone was ineffective. Furthermore, the use of the combination of OA and EO was more effective, in some respects, than their individual use

Antioxidant and antiapoptotic activities of deprenyl and estradiol co-administration in aged rat kidney

Aging is a progressive degeneration process in living organisms. Deprenyl is an irreversible monoamineoxidase B inhibitor which has antioxidant, antiapoptotic and neuroprotective effects. Estradiol is also a neuroprotective and antioxidant hormone. The objective of this study was to determine whether the antioxidative effects of deprenyl can suppress apoptotic activity, with or without estradiol, in aged female rat kidney. Wistar Albino female rats were divided into six groups as follows; young (3 months old) control, aged (24 months old) control, aged deprenyl treated, aged estradiol treated, aged deprenyl plus estradiol treated and sham. All rats except for the sham group were injected for 21 days. Determination of oxidative stress parameter was performed spectrophotometrically. To detect apoptotic cells, TUNEL staining and caspase-3 immunohistochemistry were performed. Deprenyl and estradiol administration, alone or in combination, decreased significantly the levels of lipid peroxidation relative to aged control and sham-injected rats. The number of TUNEL positive cells decreased significantly in deprenyl and estradioltreated rats compared with aged control and sham rats. Deprenyl and estradiol replacement attenuated age-related changes in renal morphology. The results indicate that deprenyl treatment alone, or in combination with estradiol, may modulate age-related apoptotic changes in rat kidney by decreasing oxidative stress

NEBIVOLOL PREVENTS RESTENOSIS BY INHIBITING INFLAMMATION, PROLIFERATION AND PLATELET AGGREGATION IN HIGH GLUCOSE-INDUCED HUMAN SAPHENOUS VEIN GRAFTS

[No Abstract Available]Scientific Research Projects Coordination Unit, Ege University, Turkey [TDK-2020-21833]The authors would like to thank to the Scientific Research Projects Coordination Unit, Ege University, Turkey (B.Reel, TDK-2020-21833) for financial support

Treatment with ginseng ameliorates chronic histopathologic changes in a mouse model of asthma

27th Congress of the European-Academy-of-Allergology-and-Clinical-Immunology -- JUN 07-11, 2008 -- Barcelona, SPAINWOS: 000256235601525European Acad Allergol & Clinical Immuno

Efficacy of nebulized sildenafil on lung histopathology in a murine model of chronic asthma

27th Congress of the European-Academy-of-Allergology-and-Clinical-Immunology -- JUN 07-11, 2008 -- Barcelona, SPAINWOS: 000256235601524European Acad Allergol & Clinical Immuno

Effects of Hedera helix and gingko biloba treatments on chronic histopathologic changes in a mouse model of asthma

27th Congress of the European-Academy-of-Allergology-and-Clinical-Immunology -- JUN 07-11, 2008 -- Barcelona, SPAINWOS: 000256235601523European Acad Allergol & Clinical Immuno

Carnosine attenuates oxidative stress and apoptosis in transient cerebral ischemia in rats

Cerebral ischemia leads to cognitive decline and neuronal damage in the hippocampus. Reactive oxygen species (ROS) play an important role in the neuronal loss after cerebral ischemia and reperfusion injury. Carnosine has both antioxidant and neuroprotective effects against ROS. In the present study, the effects of carnosine on oxidative stress, apoptotic neuronal cell death and spatial memory following transient cerebral ischemia in rats were investigated. Transient ischemia was induced by occlusion of right common carotid artery of rats for 30 min and reperfusion for 24 h or 1 week. Rats received intraperitoneal injection of 250 mg/kg carnosine or saline 30 min prior to experiment. Determination of antioxidant enzyme activities was performed spectrophotometrically. To detect apoptotic cells, TUNEL staining was performed using an In Situ Cell Death Detection Kit. Carnosine treatment elicited a significant decrease in lipid peroxidation and increase in antioxidant enzyme activities in ischemic rat brains. The number of TUNEL-positive cells was decreased significantly in carnosine-treated group when compared with the ischemia-induction group. Carnosine treatment did not provide significant protection from ischemia induced deficits in spatial learning. The results show that carnosine is effective as a prophylactic treatment for brain tissue when it is administered before ischemia without affecting spatial memory

Effect of Hedera Helix on Lung Histopathology in Chronic Asthma

WOS: 000312802400006PubMed ID: 23264408Hedera helix is widely used to treat bronchial asthma for many years. However, effects of this herb on lung histopathology is still far from clear. We aimed to determine the effect of oral administration of Hedera helix on lung histopathology in a murine model of chronic asthma. BALB/c mice were divided into four groups; I (Placebo), II (Hedera helix), III (Dexamethasone) and IV (Control). All mice except controls were sensitized and challenged with ovalbumin. Then, mice in group I received saline, group II 100 mg/kg Hedera helix and group III 1 mg/kg dexamethasone via orogastic gavage once daily for one week. Airway histopathology was evaluated by using light and electron microscopy in all groups. Goblet cell numbers and thicknesses of basement membrane were found significantly lower in group II, but there was no statistically significant difference in terms of number of mast cells, thicknesses of epithelium and subepithelial smooth muscle layers between group I and II. When Hedera helix and dexamethasone groups were compared with each other, thickness of epithelium, subepithelial muscle layers, number of mast cells and goblet cells of group III were significantly ameliorated when compared with the group II. Although Hedera helix administration reduced only goblet cell counts and the thicknesses of basement membrane in the asthmatic airways, dexamethasone ameliorated all histopathologic parameters except thickness of basement membrane better than Hedera helix

A novel incentive-based retail demand response program for collaborative participation of small customers

Integration of aggregated demand response into the wholesale electricity market is an emerging field of research. Contrary to conventional service providers, most of the demand side participants act voluntarily. However, due to wholesale market regulations, reliable and effective participation of huge numbers of customers is a vital task for aggregators. The existing retail programs aim to motivate customers to take part in events in return for static or individual performance-based incentives. These programs do not focus on engaging customers to act in a collaborative way and therefore have limited effectiveness. This study proposes a novel retail demand response program in which the incentives are dependent on the aggregated performance of participants. Considering the existing wholesale and retail market structures together with demand response aggregator responsibilities, an adaptable program is developed for more effective performance and indirect collaboration of customers. The contribution of the program is compared with a number of different DR programs adopting concepts from game theory