6 research outputs found
Could Inflammatory Indices and Metabolic Syndrome Predict the Risk of Cancer Development? Analysis from the Bagnacavallo Population Study
Background: Despite the robust data available on inflammatory indices (neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and systemic immune-inflammation index (SII)) and clinical outcome in oncological patients, their utility as a predictor of cancer incidence in the general population has not been reported in literature. Methods: The Bagnacavallo study was performed between October 2005 and March 2009. All citizens of Bagnacavallo (Ravenna, Emilia-Romagna, Italy) aged 30-60 years as of January 2005 were eligible and were invited by written letter to participate to the study. All participants underwent a detailed clinical history and physical examination following the model of the Dionysos Study. All blood values included in the analysis were obtained the day of physical examination. Cancer incidence data were obtained from the population-based Romagna Cancer Registry, which operates according to standard methods. The aim of this analysis was to examine the association between metabolic syndrome and baseline SII, NLR, and PLR levels, and the diagnosis of an invasive cancer in the Bagnacavallo study cohort. Results: At univariate analysis, metabolic syndrome was not associated with an increase of cancer incidence (HR 1.30; p = 0.155). High glucose (HR 1.49; p = 0.0.16), NLR HR 1.54, p = 0.002), PLR (HR 1.58, p = 0.001), and SII (HR 1.47, p = 0.006) were associated with an increase of cancer incidence. After adjusting for clinical covariates (smoking, physical activity, education, age, and gender) SII, PLR, and NLR remained independent prognostic factors for the prediction of cancer incidence. Conclusions: Inflammatory indices are promising, easy to perform, and inexpensive tools for identifying patients with higher risk of cancer in cancer-free population
Messa a 2 voce del P. da Bagnacavallo
RĂ©unit : "Messa a 2 voce del P. da Bagnacavallo" (Parties de tĂ©nor et de basse)Titre et texte en Ă©criture cursive Ă l'encre noire. - PortĂ©e de cinq lignes Ă l'encre marron. - Notation ronde Ă l'encre noire. - ClĂ©s : Ut 4 ; Fa 4. - P. [1] et [9] indications respectives : "Tenore" et "Basso". - P. [11] indication : "Allegro". - Sur plusieurs marges de droite indications des diffĂ©rentes parties de la messe. - Sur plusieurs marges de droite mention "Addo". - DatĂ© d'aprĂšs la calligraphie du documentPrĂ©sentation musicale : [Parties]Appartient Ă lâensemble documentaire : RISM2Appartient Ă lâensemble documentaire : Liturg.Appartient Ă lâensemble documentaire : RISMMs
Could Inflammatory Indices and Metabolic Syndrome Predict the Risk of Cancer Development? Analysis from the Bagnacavallo Population Study
Background: Despite the robust data available on inflammatory indices (neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and systemic immune-inflammation index (SII)) and clinical outcome in oncological patients, their utility as a predictor of cancer incidence in the general population has not been reported in literature. Methods: The Bagnacavallo study was performed between October 2005 and March 2009. All citizens of Bagnacavallo (Ravenna, Emilia-Romagna, Italy) aged 30â60 years as of January 2005 were eligible and were invited by written letter to participate to the study. All participants underwent a detailed clinical history and physical examination following the model of the Dionysos Study. All blood values included in the analysis were obtained the day of physical examination. Cancer incidence data were obtained from the population-based Romagna Cancer Registry, which operates according to standard methods. The aim of this analysis was to examine the association between metabolic syndrome and baseline SII, NLR, and PLR levels, and the diagnosis of an invasive cancer in the Bagnacavallo study cohort. Results: At univariate analysis, metabolic syndrome was not associated with an increase of cancer incidence (HR 1.30; p = 0.155). High glucose (HR 1.49; p = 0.0.16), NLR HR 1.54, p = 0.002), PLR (HR 1.58, p = 0.001), and SII (HR 1.47, p = 0.006) were associated with an increase of cancer incidence. After adjusting for clinical covariates (smoking, physical activity, education, age, and gender) SII, PLR, and NLR remained independent prognostic factors for the prediction of cancer incidence. Conclusions: Inflammatory indices are promising, easy to perform, and inexpensive tools for identifying patients with higher risk of cancer in cancer-free population
External Validation of Surrogate Indices of Fatty Liver in the General Population: the Bagnacavallo Study
We externally validated the fatty liver index (FLI), the lipid accumulation product (LAP), the hepatic steatosis index (HSI), and the Zhejiang University index (ZJU) for the diagnosis of fatty liver (FL) and non-alcoholic fatty liver disease (NAFLD) in the general population. The validation was performed on 2159 citizens of the town of Bagnacavallo (Ravenna, Italy). Calibration was evaluated by calculating the calibration slope and intercept and by inspecting calibration plots; discrimination was evaluated using the c-statistic. The average calibration slope was 1 and the average intercept was 0 for all combinations of outcomes and indices. For the diagnosis of FL, the c-statistic was 0.85 for FLI, 0.83 for ZJU, 0.82 for HSI, and 0.80 for LAP; for the diagnosis of NAFLD, the c-statistic was 0.77 for FLI, 0.76 for ZJU, 0.75 for HSI, and 0.74 for LAP. All indices were strongly correlated with each other. In conclusion, FLI, LAP, HSI, and ZJU perform similarly well to diagnose FL and NAFLD in the Bagnacavallo population, even if FLI has a small advantage as discrimination is concerned
LâattivitĂ dei Centri Antifumo italiani tra problematiche e aree da potenziare: i risultati di unâindagine svolta attraverso un questionario on-line
Introduzione. In Italia sono 295 i Servizi per la cessazione dal
fumo di tabacco (Centri Antifumo - CA) afferenti al Servizio Sanitario
Nazionale (SSN) censiti nel 2011 dallâOsservatorio Fumo,
Alcol e Droga (OssFAD) dellâIstituto Superiore di SanitĂ . La presente
indagine, condotta dallâOssFAD in collaborazione con i CA,
Ăš stata volta a rilevare alcune delle problematiche con le quali il
personale dei CA si confronta per portare avanti la propria attivitĂ
e le iniziative ritenute utili per migliorarla.
Materiali e metodi. Lâindagine Ăš stata condotta dal 7 al 21
maggio 2012, mediante un questionario compilabile on-line
composto da 5 brevi sezioni di domande con un totale di 38
items da completare. Il link al questionario on-line Ăš stato inviato
per e-mail a 322 indirizzi dei CA censiti nel 2011 dallâOssFAD. I
dati raccolti sono stati elaborati statisticamente con il programma
SPSS 20.
Risultati. Allâindagine hanno risposto 146 operatori dei CA
(45,3%). Sebbene ci siano aspetti ormai consolidati dellâattivitĂ
dei CA, sono ancora molte le criticitĂ che gli operatori riscontrano
nella loro attivitĂ . Le principali problematiche che influiscono
in modo fondamentale/rilevante per la buona attivitĂ
del centro sono le âScarse o nulle risorse economicheâ per il
60,7% del personale, âla mancanza di personale dedicatoâ per
il 52,4% del personale; il âriconoscimento/mandato istituzionale
del CAâ per il 40,9% del personale. Tra le azioni ritenute
piĂč efficaci per facilitare lâaccesso ai CA sono risultate la sensibilizzazione
del personale sanitario (91%), in particolare dei medici
di famiglia e lâinserimento delle prestazioni antitabagiche
nei LEA (76,8%).
Conclusioni. Ă auspicabile che lâattivitĂ dei CA riceva una maggiore
attenzione, attraverso la dotazione di strutture, personale
e finanziamenti adeguati a svolgere un importante ruolo nella
tutela e promozione della salute