Analysis between financial leverage with the stock price and the operational performance of the accepted companies in Tehran’s stock market

In this study, the relationships between the changes of the economic leverage and the operational performance of the accepted companies of Tehran’s stock market were analyzed. The main goal of this study is to determine if there is a meaningful relationship between the changes of the economic leverage and the operational performance of the accepted companies of Tehran’s stock market. For this purpose, 145 companies from 2005 to 2006 with systematic elimination method were selected. The results indicated that there was a meaningful relationship between the economic leverage and the stock price. The results showed that an increase in the debt led to an increase in the relationship between the economic leverage and the stock price. Also, the study showed that the relationship between the economic leverage and the stock price is a meaningful and negative relationship. Finally, the study indicated the change of the economic leverage and the ratio of expenses to property is a negative and meaningful relationship

Analysis between financial leverage with the stock price and the operational performance of the accepted companies in Tehran’s stock market

In this study, the relationships between the changes of the economic leverage and the operational performance of the accepted companies of Tehran’s stock market were analyzed. The main goal of this study is to determine if there is a meaningful relationship between the changes of the economic leverage and the operational performance of the accepted companies of Tehran’s stock market. For this purpose, 145 companies from 2005 to 2006 with systematic elimination method were selected. The results indicated that there was a meaningful relationship between the economic leverage and the stock price. The results showed that an increase in the debt led to an increase in the relationship between the economic leverage and the stock price. Also, the study showed that the relationship between the economic leverage and the stock price is a meaningful and negative relationship. Finally, the study indicated the change of the economic leverage and the ratio of expenses to property is a negative and meaningful relationship

Analysis between financial leverage with the stock price and the operational performance of the accepted companies in Tehran’s stock market

In this study, the relationships between the changes of the economic leverage and the operational performance of the accepted companies of Tehran’s stock market were analyzed. The main goal of this study is to determine if there is a meaningful relationship between the changes of the economic leverage and the operational performance of the accepted companies of Tehran’s stock market. For this purpose, 145 companies from 2005 to 2006 with systematic elimination method were selected. The results indicated that there was a meaningful relationship between the economic leverage and the stock price. The results showed that an increase in the debt led to an increase in the relationship between the economic leverage and the stock price. Also, the study showed that the relationship between the economic leverage and the stock price is a meaningful and negative relationship. Finally, the study indicated the change of the economic leverage and the ratio of expenses to property is a negative and meaningful relationship

Molecular Typing of Salmonella paratyphi B and Salmonella paratyphi C Isolates from Clinical Samples in Iran

Background & Objective: Molecular typing is an important tool in surveillance and outbreak investigations of human Salmonella infections. In this study, Subtyping of Salmonella Paratyphi B and C isolates derived from Iranian patients was carried out by RAPD-PCR to assess the extent of genetic diversity of these isolates. Materials & Methods: Fourteen Salmonella isolates including 6 strains of Salmonella paratyphi B and 8 strains of Salmonella paratyphi C were characterized using RAPD-PCR. Two arbitrary primers, namely OPP-16 and P1254 were used for RAPD analysis and the dendrograms were constructed with NTsys 2.0 computer software. Results: Both primers showed high discriminatory power in differentiating of the related strains of Salmonella. The dendrograms constructed based on RAPD-PCR profiles (with both primers) involving 14 salmonella strains revealed 4 distinct patterns, indicating that these isolates are genetically heterogeneous. Furthermore, a good correlation was not observed between the serotype and the molecular profiles obtained from RAPD data of the Salmonella isolates. Conclusion: The findings of the present study verify the usefulness of RAPD-PCR in characterizing and comparing strains of Salmonella Paratyphi B and C

Downregulation of miR-146a promotes cell migration in Helicobacter pylori–negative gastric cancer

MicroRNAs (miRs) are short noncoding RNAs that post-transcriptionally suppress gene expression. miR-146a acts as an oncogene or a tumor suppressor in various cancers, including gastric cancer, but it is unclear what determines whether miR-146a is oncogenic or tumor suppressive and the molecular mechanisms are still largely unknown. The aim of this study was to investigate the role of miR-146a in gastric cancer, by focusing on its expression in patients who were negative for Helicobacter pylori and its reduced and increased expression effect in vitro. Twenty gastric cancer patients who were negative for H. pylori infection were selected and the expression levels of miRNA-146a in these gastric tumors, in their matched normal gastric tissues and in gastric cancer cell lines with varying tumorigenic potential was measured. Further, the impact of increased and decreased miR-146a expression levels on the expression of predicted target genes, cell migration, viability, proliferation, and apoptosis was examined, respectively. Our results for the first time indicated that miR-146a is downregulated in H. pylori–negative gastric cancers and suggests that H. pylori infection determines whether miR-146a acts as an oncogene or tumor suppressor. The level of miR-146a expression inversely correlates with the tumorigenicity of three gastric cancer cell lines and low miR-146a expression predicts poor recurrence-free survival. It was also found that miR-146a reduces the expression levels of the prometastatic genes and suppresses MKN-45 cell migration. Functional studies showed that miR-146a acts as a tumor suppressor miR and identifies miR-146a as a candidate for antimetastatic miRNA replacement therapy for gastric cancer patients