A Descriptive Study to Assess the New Graduate Nurses Performance in Christian Mission Hospital, Madurai

Introduction: Today’s healthcare environment demands efficient use of resources. Because of the ongoing shortage and increasing acuity of patients, new graduate nurses must master both psychomotor and critical skills rapidly. Health care leaders must examine the competencies needed for new graduate nurses to succeed in this environment. Methodology: Descriptive design was adopted for this study. In which 10 new graduate staff nurse were selected as samples from non-probability purposive sampling technique. The study was conducted at Christian mission hospital, Madurai. A structured checklist questionnaire was formulated based on technical area, communication, professionalism and personal conduct for the data collection procedure. The study was conducted among new graduate nurse in Christian mission hospital, Madurai. Results: The finding revealed that majority of new graduate nurses had moderate level of performance 6 (60%). Least number of new graduate nurses had low level of performance 1 (10%).and 3(30%) had high level of performance

Cardiac morbidity in HIV infection is associated with checkpoint inhibitor LAG-3 on CD4 T cells

Recent findings point to a role of Checkpoint Inhibitor (CPI) receptors at the tissue level in immune homeostasis. Here we investigated the role of CPI molecules on immune cells in relation to cardiac function. Participants recruited in Chennai, India consisted of HIV+ ART naive viremic (Gp1 n = 102), HIV+ on ART, virologically suppressed (Gp2, n = 172) and HIV negative healthy controls (Gp3, n = 64). A cross-sectional analysis of cardiac function, arterial resistance and immunologic assessment of CPI expressing T cells was performed. Data indicate that ART naive exhibited cardiac function impairment and greater arterial stiffness than the other groups. Frequencies of CD4+ T cells expressing LAG-3 and PD1 were higher in ART naïve while TIGIT and TIM3 were similar among the patient groups. LAG-3+, PD1+ and dual LAG-3+PD1+ CD4 T cells were inversely correlated with cardiac function and arterial elasticity and directly with arterial stiffness in ART naïve participants and with arterial elasticity in virally suppressed group on ART. We conclude that HIV induced upregulation of LAG-3 singly or in combination with PD1 in immune cells may regulate cardiac health and warrant mechanistic investigations. The implications of these findings have bearing for the potential utility of anti-LAG-3 immunotherapy for cardiac dysfunction in chronic HIV infection