Platelets and Inflammation: Relations between Platelet Counts and Markers of Inflammation

Platelets, or thrombocytes are small non-nucleated cells that are primarily responsible for the formation of the platelet plug, and consequently in primary hemostasis. However, their role is not limited only to a response to cell injury, but they also respond to systemic inflammation. Due to factors such as a shared lineage with other cells of the blood, recent studies showing the molecular expression of immune modulators on platelets, and the release of inflammatory molecules leading to chemoattraction by responder molecules. These implications may also go deeper into the pathogenesis of cancers in the human body, and quantification of that relation, platelets with inflammation, is the aim of the stud

Platelets and Inflammation: Relations between Platelet Counts and Markers of Inflammation

Platelets, or thrombocytes are small non-nucleated cells that are primarily responsible for the formation of the platelet plug, and consequently in primary hemostasis. However, their role is not limited only to a response to cell injury, but they also respond to systemic inflammation. Due to factors such as a shared lineage with other cells of the blood, recent studies showing the molecular expression of immune modulators on platelets, and the release of inflammatory molecules leading to chemoattraction by responder molecules. These implications may also go deeper into the pathogenesis of cancers in the human body, and quantification of that relation, platelets with inflammation, is the aim of the stud

Endoillumination (chandelier) and wide-angle viewing-assisted fine-needle aspiration biopsy of intraocular mass lesions

Fine-needle aspiration biopsy (FNAB) of intraocular mass lesions is an important intervention in the presence of diagnostic difficulty. FNAB of intraocular mass lesions is also likely to become more commonly recommended for prognostication of tumors such as choroidal melanoma. The most commonly described approach for tumor localization and visualization during FNAB is transillumination and indirect ophthalmoscopic viewing. Herein, we report endoillumination (chandelier) and wide-angle viewing assisted, microscope-based approach for FNAB in two patients using two port minimally invasive vitreoretinal surgical approach. The submission is supported by a video demonstration. The entire procedure was completed under the microscope. Adequate sample was obtained. In the first patient, the inflammatory nature of the lesion was confirmed though magnetic resonance imaging had been reported as melanoma. In the second patient, a clinical diagnosis of amelanotic melanoma was confirmed. Endoillumination-assisted FNAB of intraocular mass lesions is easier to learn and more precise and hence carries lesser risks