128 research outputs found
High spectral resolution imaging of the dynamical atmosphere of the red supergiant Antares in the CO first overtone lines with VLTI/AMBER
We present high spectral resolution aperture-synthesis imaging of the red
supergiant Antares (alpha Sco) in individual CO first overtone lines with
VLTI/AMBER. The reconstructed images reveal that the star appears differently
in the blue wing, line center, and red wing and shows an asymmetrically
extended component. The appearance of the star within the CO lines changes
drastically within one year, implying a significant change in the velocity
field in the atmosphere. Our modeling suggests an outer atmosphere (MOLsphere)
extending to 1.2--1.4 stellar radii with CO column densities of
(0.5--1)x10^{20} cm^{-2} and a temperature of ~2000 K. While the velocity field
in 2009 is characterized by strong upwelling motions at 20--30 km/s, it changed
to strong downdrafts in 2010. On the other hand, the AMBER data in the
continuum show only a slight deviation from limb-darkened disks and only
marginal time variations. We derive a limb-darkened disk diameter of
37.38+/-0.06 mas and a power-law-type limb-darkening parameter of
(8.7+/-1.6)x10^{-2} (2009) and 37.31+/-0.09 mas and (1.5+/-0.2)x10^{-1} (2010).
We also obtain Teff = 3660+/-120 K and log L/Lsun = 4.88+/-0.23, which suggests
a mass of 15+/-5 Msun with an age of 11-15 Myr. This age is consistent with the
recently estimated age for the Upper Scorpius OB association. The properties of
the outer atmosphere of Antares are similar to those of another well-studied
red supergiant, Betelgeuse. The density of the extended outer atmosphere of
Antares and Betelgeuse is higher than predicted by the current 3-D convection
simulations by at least six orders of magnitude, implying that convection alone
cannot explain the formation of the extended outer atmosphere.Comment: 18 pages, 16 figures, accepted for publication in Astronomy and
Astrophysics, short discussion on the age of Antares and the Upper Scorpius
OB association added, movies of the reconstructed images available at
http://www.mpifr-bonn.mpg.de/staff/kohnaka
SKA CSP controls: technological challenges
The Square Kilometer Array (SKA) project is an international effort to build the world's largest radio telescope, with eventually over a square kilometer of collecting area. For SKA Phase 1, Australia will host the low-frequency instrument with more than 500 stations, each containing around 250 individual antennas, whilst South Africa will host an array of close to 200 dishes. The scale of the SKA represents a huge leap forward in both engineering and research and development towards building and delivering a unique instrument, with the detailed design and preparation now well under way. As one of the largest scientific endeavors in history, the SKA will brings together close to 100 organizations from 20 countries. Every aspect of the design and development of such a large and complex instrument requires state-of-the-art technology and innovative approach. This poster (or paper) addresses some aspects of the SKA monitor and control system, and in particular describes the development and test results of the CSP Local Monitoring and Control prototype. At the SKA workshop held in April 2015, the SKA monitor and control community has chosen TANGO Control System as a framework, for the implementation of the SKA monitor and control. This decision will have a large impact on Monitor an Control development of SKA. As work is on the way to incorporate TANGO Control System in SKA is in progress, we started to development a prototype for the SKA Central Signal Processor to mitigate the associated risks. In particular we now have developed a uniform class schema proposal for the sub-Element systems of the SKA-CSP
The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors
Alterations of human chromosome 8p occur frequently in many tumors. We identified a 1.5-Mb common region of allelic loss on 8p22 by allelotype analysis, cDNA selection allowed isolation of several genes, including FEZ1. The predicted Fez1 protein contained a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. RNA blot analysis revealed that FEZ1 gene expression was undetectable in more than 60% of epithelial tumors. Mutations were found in primary esophageal cancers and in a prostate cancer cell line. Transcript analysis from several FEZ1-expressing tumors revealed truncated mRNAs, including a frameshift. Alteration and inactivation of the FEZ1 gene may play a role in various human tumors
The FHIT Gene, Spanning the Chromosome 3p14.2 Fragile Site and Renal Carcinoma–Associated t(3;8) Breakpoint, Is Abnormal in Digestive Tract Cancers
AbstractA 200–300 kb region of chromosome 3p14.2, including the fragile site locus FRA3B, is homozygously deleted in multiple tumor-derived cell lines. Exon amplification from cosmids covering this deleted region allowed identification of the human FHIT gene, a member of the histidine triad gene family, which encodes a protein with 69% similarity to an S. pombe enzyme, diadenosine 5′, 5′′′ P1, P4-tetraphosphate asymmetrical hydrolase. The FHIT locus is composed of ten exons distributed over at least 500 kb, with three 5′ untranslated exons centromeric to the renal carcinoma–associated 3p14.2 breakpoint, the remaining exons telomeric to this translocation breakpoint, and exon 5 within the homozygously deleted fragile region. Aberrant transcripts of the FHIT locus were found in ∼50% of esophageal, stomach, and colon carcinomas
FHIT gene therapy prevents tumor development in Fhit-deficient mice
The tumor suppressor gene FHIT spans a common fragile site and is highly susceptible to environmental carcinogens. FHIT inactivation and loss of expression is found in a large fraction of premaligant and malignant lesions. In this study, we were able to inhibit tumor development by oral gene transfer, using adenoviral or adenoassociated viral vectors expressing the human FHIT gene, in heterozygous Fhit+/- knockout mice, that are prone to tumor development after carcinogen exposure. We therefore suggest that FHIT gene therapy could be a novel clinical approach not only in treatment of early stages of cancer, but also in prevention of human cancer
Northern JHK Standard Stars for Array Detectors
We report J, H and K photometry of 86 stars in 40 fields in the northern hemisphere. The fields are smaller than or comparable to a 4x4 arcmin field-of-view, and are roughly uniformly distributed over the sky, making them suitable for a homogeneous broadband calibration network for near-infrared panoramic detectors. K magnitudes range from 8.5 to 14, and J-K colors from -0.1 to 1.2. The photometry is derived from a total of 3899 reduced images; each star has been measured, on average, 26.0 times per filter on 5.5 nights. Typical errors on the photometry are about 0.012
Collecting duct carcinoma of the kidney: an immunohistochemical study of 11 cases
BACKGROUND: Collecting duct carcinoma (CDC) is a rare but very aggressive variant of kidney carcinoma that arises from the epithelium of Bellini's ducts, in the distal portion of the nephron. In order to gain an insight into the biology of this tumor we evaluated the expression of five genes involved in the development of renal cancer (FEZ1/LZTS1, FHIT, TP53, P27(kip1), and BCL2). METHODS: We studied eleven patients who underwent radical nephrectomy for primary CDC. All patients had an adequate clinical follow-up and none of them received any systemic therapy before surgery. The expression of the five markers for tumor initiation and/or progression were assessed by immunohistochemistry and correlated to the clinicopathological parameters, and survival by univariate analysis. RESULTS: Results showed that Fez1 protein expression was undetectable or substantially reduced in 7 of the 11 (64%) cases. Fhit protein was absent in three cases (27%). The overexpression of p53 protein was predominantly nuclear and detected in 4 of 11 cases (36%). Immunostaining for p27 was absent in 5 of 11 cases (45.5%). Five of the six remaining cases (90%) showed exclusively cytoplasmic protein expression, where, in the last case, p27 protein was detected in both nucleus and cytoplasm. Bcl2 expression with 100% of the tumor cells positive was observed in 4 of 11 (36%) cases. Statistical analysis showed a statistical trend (P = 0.06) between loss and reduction of Fez1 and presence of lymph node metastases. CONCLUSIONS: These findings suggest that Fez1 may represent not only a molecular diagnostic marker but also a prognostic marker in CDC
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