111In-Labeled Glycoprotein Nonmetastatic b (GPNMB) Targeted Gemini Surfactant-Based Nanoparticles against Melanoma: In Vitro Characterization and in Vivo Evaluation in Melanoma Mouse Xenograft Model

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New carboxysalicylaldehyde schiff base ligand and its copper(II) complexes

Metal-organic frameworks have become a subject of great interest lately because of their interesting features and applications in the field of catalysis, magnetism and biological studies [1]. Coordination polymers are most commonly the creators of such frameworks, and researchers have devoted great effort to the design of metal-generated networks with tailored properties [2,3]. Our group has recently been involved in the development of by-design structures based on 3d metal coordination complexes derived from Schiff based ligands [4]. Salen-based complexes of 3d metals, in which the Schiff base presents the carboxy substituent on the aromatic moiety, generate infinite coordination polymers in the presence of alkaline bases [5]. In this respect, we have obtained new carboxysalicylaldehyde Schiff base ligand, namely N,N'-bis(5-carboxysalicylidene-aminopropyl)piperazine (CBPP), characterized by NMR and FTIR spectroscopy and TG analysis. Copper(II) complexes of CBPP were synthesized by direct or template synthesis, isolated and characterized by FTIR; preliminary results suggest the formation of polymeric structures

Development of Radiolabeled Antibody-Targeted Gemini Nanoparticles for Melanoma

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Zirconium-89 Labeled Gene Delivery Nanoparticles as Theranostic Agents for Melanoma

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Stakeholders’ perspectives on the operationalisation of the ecosystem service concept: results from 27 case studies

The ecosystem service (ES) concept is becoming mainstream in policy and planning, but operational influence on practice is seldom reported. Here, we report the practitioners’ perspectives on the practical implementation of the ES concept in 27 case studies. A standardised anonymous survey (n=246), was used, focusing on the science-practice interaction process, perceived impact and expected use of the case study assessments. Operationalisation of the concept was shown to achieve a gradual change in practices: 13% of the case studies reported a change in action (e.g. management or policy change), and a further 40% anticipated that a change would result from the work. To a large extent the impact was attributed to a well conducted science-practice interaction process (>70%). The main reported advantages of the concept included: increased concept awareness and communication; enhanced participation and collaboration; production of comprehensive science-based knowledge; and production of spatially referenced knowledge for input to planning (91% indicated they had acquired new knowledge). The limitations were mostly case-specific and centred on methodology, data, and challenges with result implementation. The survey highlighted the crucial role of communication, participation and collaboration across different stakeholders, to implement the ES concept and enhance the democratisation of nature and landscape planning.JRC.D.2-Water and Marine Resource