„Gender fluidity“: Die Identitätskrise als Aufbrechen der Geschlechterrollen in Annemarie Schwarzenbachs 'Flucht nach oben'

The Swiss author Annemarie Schwarzenbach created literary figures that resist being classified according to a gender binary and heterosexual norm. She thereby, already in the 1930s, imagined something akin to the recent investigative work by Lisa Diamond on gender and sexual fluidity. Schwarzenbach's texts are populated by feminine men and masculine women, a genderswitching that can be interpreted as breaking apart the categories of gender and sexuality. In her novel Flucht nach oben (1933), in which the dichotomy of male and female is proven invalid, gender role models become obsolete, leading to the protagonist's deep uncertainty about his identity. Schwarzenbach’s characters can thus be called “multi–sexual” as they meld both genders as well as homo– and hetero–sexual orientations, thereby exceeding culturally fixed borders. The dichotomy between male and female becomes ever more instable, just as the labels hetero–, homo– and bisexual fall apart. In the end of the novel, the main protagonist forms a queer family together with other characters who do not fit into cultural gender norms. In contrast to earlier studies which interpret Schwarzenbach's texts biographically, I seek to use Diamond’s contemporary model indebted to queer studies. I involve, moreover, theories by Joan Rivière, René Girard, Eve Sedgwick, and Judith Butler. In addition, Flucht nach oben is read alongside Schwarzenbach's other novels – Freunde um Bernhard (1931), Lyrische Novelle (1933) and Eine Frau zu sehen (1929). These works serve as intertexts that contribute to a deeper understanding of the recurring character types and constellations of relationships in Schwarzenbach’s oeuvre

Preparedness for Data-Driven Business Model Innovation:A Knowledge Framework for Incumbent Manufacturers

This study investigates data-driven business model innovation (DDBMI) for incumbent manufacturers, underscoring its importance in various strategic and managerial contexts. Employing topic modeling, the study identifies nine key topics of DDBMI. Through qualitative thematic synthesis, these topics are further refined, interpreted, and categorized into three levels: Enablers, value creators, and outcomes. This categorization aims to assess incumbent manufacturers’ preparedness for DDBMI. Additionally, a knowledge framework is developed based on the identified nine key topics of DDBMI to aid incumbent manufacturers in enhancing their understanding of DDBMI, thereby facilitating the practical application and interpretation of data-driven approaches to business model innovation.</p

Cross-Impact Analysis of Entrepreneurial Failure and Business Model Innovation:Navigating the Impact of Societal Perceptions

Failed entrepreneurs often encounter negative societal perceptions that impede their ability to learn from failure, take risks, and innovate business models. Reducing this stigma appears crucial to support entrepreneurship and foster innovation. However, the precise relationship between stigma reduction and desired outcomes remains uncertain. This study addresses this gap by examining the variables influencing the perception of business failure. Through a systematic literature review and content analysis, we identified 20 variables within the network. A subsequent cross-impact analysis helped delineate these variables as critical, influential, dependent, inert, or neuter. Stigma emerged as the critical variable, exerting significant influence. Culture, bankruptcy laws, social capital, the frequency of business failures, and entrepreneurial attributes played pivotal roles as influential variables. Dependent variables encompassed the rate of entrepreneurship, entrepreneurial intention, and learning from failure. This study underscores the importance of comprehending the interplay between these variables and their impact on entrepreneurial outcomes. Although the influence of societal perceptions on business model innovation proved minimal, failed entrepreneurs displayed resilience in defying stigma and engaging in innovative endeavors. Our findings shed light on the significance of societal perceptions within entrepreneurial ecosystems and the adaptability of entrepreneurs in innovating existing business models. This study lays a foundation for further research into the dynamics of these influences.</p

Assessing the current landscape of AI and sustainability literature:Identifying key trends, addressing gaps and challenges

The United Nations’ 17 Sustainable Development Goals stress the importance of global and local efforts to address inequalities and implement sustainability. Addressing complex, interconnected sustainability challenges requires a systematic, interdisciplinary approach, where technology, AI, and data-driven methods offer potential solutions for optimizing resources, integrating different aspects of sustainability, and informed decision-making. Sustainability research surrounds various local, regional, and global challenges, emphasizing the need to identify emerging areas and gaps where AI and data-driven models play a crucial role. The study performs a comprehensive literature survey and scientometric and semantic analyses, categorizes data-driven methods for sustainability problems, and discusses the sustainable use of AI and big data. The outcomes of the analyses highlight the importance of collaborative and inclusive research that bridges regional differences, the interconnection of AI, technology, and sustainability topics, and the major research themes related to sustainability. It further emphasizes the significance of developing hybrid approaches combining AI, data-driven techniques, and expert knowledge for multi-level, multi-dimensional decision-making. Furthermore, the study recognizes the necessity of addressing ethical concerns and ensuring the sustainable use of AI and big data in sustainability research.</p

Shear wave elastography-based liver fibrosis assessment in patients with chronic hepatitis E displays elevated liver stiffness regardless of previous antiviral therapy

Background: Hepatitis E virus (HEV) infection especially in immunocompromised individuals can lead to chronic hepatitis. Aggressive courses of chronic hepatitis E leading to liver cirrhosis in a short period of time have been described, but evidence on the degree of liver involvement in chronic hepatitis E is rare. Vie therefore aimed to quantify liver fibrosis in patients with chronic active hepatitis E compared to patients with sustained virological response after ribavirin (RBV) treatment using 2D-shear wave elastography (2D-SWE) to measure liver stiffness. Methods: Patients with chronic hepatitis E underwent 2D-SWE, B-mode and Doppler ultrasound and laboratory testing in order to assess severity of liver involvement. Results: In this cross-sectional study, we included 14 patients of whom 8 had ongoing chronic hepatitis E and 6 patients had been successfully treated for chronic hepatitis E. The most frequent cause for immunosuppression was prior kidney transplantation (n = 12), one patient was a multivisceral transplant recipient, one had been treated for lymphoma. Five patients cleared HEV after RBV therapy, one patient reached viral clearance after reduction of his immunosuppressive medication. Using 2D-SWE measurement, 71.4% displayed increased stiffness indicative of liver fibrosis: 57.1% classified as significant fibrosis and 14.3% as severe fibrosis. Liver stiffness did not differ between patients with active chronic hepatitis E and in patients who had cleared HEN (1.59 and 1.54 m/S respectively). Compared with a control group of kidney transplant recipients without hepatitis E (1.44 m/S), the patients with a history of hepatitis E displayed a significantly higher liver stiffness (P=0.04). Conclusions: In our cohort of chronic hepatitis E patients, elevated liver stiffness indicating liver fibrosis was common and significantly higher than in controls. This is consistent with prior sparse reports of the presence of liver fibrosis or cirrhosis in chronic hepatitis E and emphasizes the need for HEV testing, therapy and research on new therapeutic options. As elevated liver stiffness was also present in patients after HEV treatment, continuous liver surveillance including elastography and ultrasound should be considered

Copernicus Cal/Val Solution - D1.1 - Optical Missions Cal/Val requirements

This document intends to identify the requirements applicable to the calibration and validation (Cal/Val) activities for the optical missions of the Copernicus Space Component. These optical missions can be further classified as Surface Colour and Surface Temperature missions. Missions dedicated to atmosphere composition are addressed in a specific document and as such excluded from the present document, even if based on optical remote sensing techniques. Copernicus Space Component Surface Colour missions are: ▪ Sentinel2/MSI ▪ Sentinel3/OLCI ▪ Sentinel3/SYN ▪ CHIME Copernicus Space Component Surface Temperature missions are: ▪ Sentinel3/SLSTR ▪ LST

The underestimated burden of monogenic kidney disease in adults waitlisted for kidney transplantation

Purpose: Chronic kidney disease (CKD) is a major health-care burden. Increasing evidence suggests that a considerable proportion of patients are affected by a monogenic kidney disorder. Methods: In this study, the kidney transplantation waiting list at the Charité was screened for patients with undetermined cause of CKD. By next-generation sequencing (NGS) we targeted all 600 genes described and associated with kidney disease or allied disorders. Results: In total, 635 patients were investigated. Of these, 245 individuals had a known cause of CKD (38.5%) of which 119 had a proven genetic disease (e.g., ADPKD, Alport). The other 340 patients (53.5%) were classified as undetermined diagnosis, of whom 87 had kidney failure (KF) onset <40 years. To this latter group genetic testing was offered as well as to those patients (n = 29) with focal segmental glomerulosclerosis (FSGS) and all individuals (n = 21) suspicious for thrombotic microangiopathy (TMA) in kidney biopsy. We detected diagnostic variants in 26 of 126 patients (20.6%) of which 14 of 126 (11.1%) were pathogenic or likely pathogenic. In another 12 of 126 (9.5%) patients, variants of unknown significance (VUS) were detected. Conclusion: Our study demonstrates the diagnostic value of comprehensive genetic testing among patients with undetermined CKD

PEBRA trial - effect of a peer-educator coordinated preference-based ART service delivery model on viral suppression among adolescents and young adults living with HIV: protocol of a cluster-randomized clinical trial in rural Lesotho

Despite tremendous progress in controlling the HIV epidemic in sub-Saharan Africa, HIV-related mortality continues to increase among adolescents and young people living with HIV (AYPLHIV). Globally, sub-Saharan Africa accounts for 85% of the AYPLHIV. Overall outcomes along the HIV care cascade are worse among AYPLHIV as compared to all other age groups due to various challenges in accessing and adhering to antiretroviral therapy (ART). New, innovative multicomponent packages of differentiated service delivery (DSD) models, are required to address the specific needs of AYPLHIV. This study aims to evaluate the feasibility and effectiveness of a multicomponent DSD model (PEBRA model) designed for AYPLHIV and coordinated by a peer-educator.; PEBRA (Peer-Educator Based Refill of ART) is a cluster randomized, open-label, superiority trial conducted at 20 health facilities in three districts of Lesotho, Southern Africa. The clusters (health facilities) are randomly assigned to either the PEBRA model or standard of care in a 1:1 ratio, stratified by district. AYPLHIV aged 15-24 years old in care and on ART at one of the clusters are eligible. In the PEBRA model, a peer-educator coordinates the antiretroviral therapy (ART) services - such as medication pick-up, SMS notifications and support options - according to the preferences of the AYPLHIV. The peer-educator delivers this personalized model using a tablet-based application called PEBRApp. The control clusters continue to offer standard of care: ART services coordinated by the nurse. The primary endpoint is viral suppression at 12 months. Secondary endpoints include self-reported adherence to ART, quality of life, satisfaction with care and engagement in care. The target sample size is 300 AYPLHIV. Statistical analyses are conducted and reported in line with CONSORT guidelines for cluster randomized trials.; The PEBRA trial will provide evidence on the feasibility and effectiveness of an inclusive, holistic and preference-based DSD model for AYPLHIV that is coordinated by a peer-educator. Many countries in SSA have an existing peer-educator program. If proven effective, the PEBRA model and PEBRApp have the potential to be scaled up to similar settings.; Clinicaltrials.gov, NCT03969030. Registered on 31 May 2019. More information: www.pebra.info