Problem formulation for risk assessment of combined exposures to chemicals and other stressors in humans

When the human health risk assessment/risk management paradigm was developed, it did not explicitly include a "problem formulation" phase. The concept of problem formulation was first introduced in the context of ecological risk assessment (ERA) for the pragmatic reason to constrain and focus ERAs on the key questions. However, this need also exists for human health risk assessment, particularly for cumulative risk assessment (CRA), because of its complexity. CRA encompasses the combined threats to health from exposure via all relevant routes to multiple stressors, including biological, chemical, physical and psychosocial stressors. As part of the HESI Risk Assessment in the 21st Century (RISK21) Project, a framework for CRA was developed in which problem formulation plays a critical role. The focus of this effort is primarily on a chemical CRA (i.e., two or more chemicals) with subsequent consideration of non-chemical stressors, defined as "modulating factors" (ModFs). Problem formulation is a systematic approach that identifies all factors critical to a specific risk assessment and considers the purpose of the assessment, scope and depth of the necessary analysis, analytical approach, available resources and outcomes, and overall risk management goal. There are numerous considerations that are specific to multiple stressors, and proper problem formulation can help to focus a CRA to the key factors in order to optimize resources. As part of the problem formulation, conceptual models for exposures and responses can be developed that address these factors, such as temporal relationships between stressors and consideration of the appropriate ModFs

Evaluating the Chinese Revised Controlling Behaviors Scale (C-CBS-R)

The present study evaluated the utility of the Chinese version of the Revised Controlling Behaviors Scale (C-CBS-R) as a measure of controlling behaviors in violent Chinese intimate relationships. Using a mixed-methods approach, in-depth, individual interviews were conducted with 200 Chinese women survivors to elicit qualitative data about their personal experiences of control in intimate relationships. The use of controlling behaviors was also assessed using the C-CBS-R. Interview accounts suggested that the experiences of 91 of the women were consistent with the description of coercive control according to Dutton and Goodman’s (2005) conceptualization of coercion. Using the split-half validation procedure, a receiver operating characteristics (ROC) curve analysis was conducted with the first half of the sample. The area under the curve (AUC) for using the C-CBS-R to identify high control was .99, and the cutoff score of 1.145 maximized both sensitivity and specificity. Applying the cutoff score to the second half gave a sensitivity of 96% and a specificity of 95%. Overall, the C-CBS-R has demonstrated utility as a measure of controlling behaviors with a cutoff score for distinguishing high from low levels of control in violent Chinese intimate relationships

Demographic subgroup trends among adolescents in the use of various licit and illicit drugs, 1975-2014

https://deepblue.lib.umich.edu/bitstream/2027.42/137897/1/mtf-occ83.pd

Demographic subgroup trends among young adults in the use of various licit and illicit drugs, 1989-2014

https://deepblue.lib.umich.edu/bitstream/2027.42/137875/1/mtf-occ85.pd

The Monitoring the Future project after four decades: Design and procedures

https://deepblue.lib.umich.edu/bitstream/2027.42/137908/1/mtf-occ82.pd

Monitoring the Future national survey results on drug use, 1975-2013: Volume I, Secondary school students

https://deepblue.lib.umich.edu/bitstream/2027.42/137916/1/mtf-vol1_2013.pd

Spin Echo Decay in a Stochastic Field Environment

We derive a general formalism with which it is possible to obtain the time dependence of the echo size for a spin in a stochastic field environment. Our model is based on ``strong collisions''. We examine in detail three cases where: (I) the local field is Ising-like, (II) the field distribution is continuous and has a finite second moment, and (III) the distribution is Lorentzian. The first two cases show a T2 minimum effect and are exponential in time cubed for short times. The last case can be approximated by a phenomenological stretched exponential.Comment: 11 pages + 3 postscript figure

HIV/AIDS: Risk & protective behaviors among adults ages 21 to 40 in the U.S., 2004-2017

National Institute on Drug Abusehttps://deepblue.lib.umich.edu/bitstream/2027.42/146526/1/FINAL FINAL 2.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146526/3/license_rdfDescription of FINAL FINAL 2.pdf : Annual monograp

HIV/AIDS: Risk Protective Behaviors among American Young Adults, 2004-2012.

https://deepblue.lib.umich.edu/bitstream/2027.42/137918/1/mtf-hiv-aids_2012.pd