Magnifying NASA Roman GBTDS exoplanet science with coordinated observations by ESA Euclid

The ESA Euclid mission is scheduled to launch on July 1st 2023. This White Paper discusses how Euclid observations of the Galactic Bulge Time Domain Survey (GBTDS) area could dramatically enhance the exoplanet science output of the Nancy Grace Roman Space Telescope (Roman). An early Euclid pre-imaging survey of the Roman GBTDS fields, conducted soon after launch, can improve proper motion determinations for Roman exoplanet microlenses that can yield a factor of up to $\sim 5$ improvement in exoplanet mass measurements. An extended Euclid mission would also enable the possibility of sustained simultaneous observations of the GBTDS by Euclid and Roman that would achieve large gains in several areas of Roman exoplanet science, including science that is impossible to achieve with Roman alone. These include: a comprehensive demographic survey for free-floating planets that includes precision mass measurements to establish the true nature of individual candidates; detection, confirmation and mass measurements of exomoons; direct exoplanet mass measurements through parallax and finite source size effects for a large sample of bound exoplanets detected jointly by Euclid and Roman; enhanced false-positive discrimination for the large samples of transiting planets that Roman will detect. Our main recommendation to NASA and ESA is to initiate a Joint Study Group as early as possible that can examine how both missions could best conduct a coordinated campaign. We also encourage flexibility in the GBTDS scheduling.Comment: 15 pages. Submission to the NASA Roman Core Community Survey White Paper Cal

Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs

Life-threatening `breakthrough' cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS- CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals ( age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto- Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-a2 and IFN-., while two neutralized IFN-omega only. No patient neutralized IFN-ss. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population

Rubin-Euclid Derived Data Products:Initial Recommendations

This report is the result of a joint discussion between the Rubin and Euclid scientific communities. The work presented in this report was focused on designing and recommending an initial set of Derived Data products (DDPs) that could realize the science goals enabled by joint processing. All interested Rubin and Euclid data rights holders were invited to contribute via an online discussion forum and a series of virtual meetings. Strong interest in enhancing science with joint DDPs emerged from across a wide range of astrophysical domains: Solar System, the Galaxy, the Local Volume, from the nearby to the primaeval Universe, and cosmology