Optical and Quasi-Optical Analysis of System Components for a Far-Infrared Space Interferometer

Many important astrophysical processes occur at wavelengths that fall within the far-infrared band of the EM spectrum, and over distance scales that require sub-arc second spatial resolution. It is clear that in order to achieve sub-arc second resolution at these relatively long wavelengths (compared to optical/near-IR), which are strongly absorbed by the atmosphere, a space-based far-IR interferometer will be required. We present analysis of the optical system for a proposed spatial-spectral interferometer, discussing the challenges that arise when designing such a system and the simulation techniques employed that aim to resolve these issues. Many of these specific challenges relate to combining the beams from multiple telescopes where the wavelengths involved are relatively short (compared to radio interferometry), meaning that care must be taken with mirror surface quality, where surface form errors not only present potential degradation of the single system beams, but also serve to reduce fringe visibility when multiple telescope beams are combined. Also, the long baselines required for sub-arc second resolution present challenges when considering propagation of the relatively long wavelengths of the signal beam, where beam divergence becomes significant if the beam demagnification of the telescopes is not carefully considered. Furthermore, detection of the extremely weak far-IR signals demands ultra-sensitive detectors and instruments capable of operating at maximum efficiency. Thus, as will be shown, care must be taken when designing each component of such a complex quasioptical system

hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia

hMTH1 is an 8-oxodGTPase that prevents mis-incorporation of free oxidized nucleotides into genomic DNA. Base excision and mismatch repair pathways also restrict the accumulation of oxidized lesions in DNA by removing the mis-inserted 8-oxo-7,8-dihydro-2'-deoxyguanosines (8-oxodGs). In this study, we aimed to investigate the interplay between hMYH DNA glycosylase and hMTH1 for cancer cell survival by using mismatch repair defective T-cell acute lymphoblastic leukemia (T-ALL) cells. To this end, MYH and MTH1 were silenced individually or simultaneously using small hairpin RNAs. Increased sub-G1 population and apoptotic cells were observed upon concurrent depletion of both enzymes. Elevated cell death was consistent with cleaved caspase 3 accumulation in double knockdown cells. Importantly, overexpression of the nuclear isoform of hMYH could remove the G1 arrest and partially rescue the toxicity observed in hMTH1-depleted cells. In addition, expression profiles of human DNA glycosylases were generated using quantitative reverse transcriptase–PCR in MTH1 and/or MYH knockdown cells. NEIL1 DNA glycosylase, involved in repair of oxidized nucleosides, was found to be significantly downregulated as a cellular response to MTH1–MYH co-suppression. Overall, the results suggest that hMYH and hMTH1 functionally cooperate for effective repair and survival in mismatch repair defective T-ALL Jurkat A3 cells

Status of the mid-IR ELT imager and spectrograph (METIS)

The Mid-Infrared ELT Imager and Spectrograph (METIS) is one of three first light instruments on the ELT. It will provide high-contrast imaging and medium resolution, slit-spectroscopy from 3 - 19um, as well as high resolution (R ∼ 100,000) integral field spectroscopy from 2.9-5.3μm. All modes observe at the diffraction limit of the ELT, by means of adaptive optics, yielding angular resolutions of a few tens of milliarcseconds. The range of METIS science is broad, from Solar System objects to active galactic nuclei (AGN). We will present an update on the main science drivers for METIS: circum-stellar disks and exoplanets. The METIS project is now in full steam, approaching its preliminary design review (PDR) in 2018. In this paper we will present the current status of its optical, mechanical and thermal design as well as operational aspects. We will also discuss the challenges of building an instrument for the ELT, and the required technologies. © 2018 SPIE

Study of payload technologies for future far-infrared space-based interferometers

This thesis focuses on the study of three technologies that are strongly related to the development of payload instrumentation for a far-infrared space interferometer. Each of them tackles a different aspect that needs to be taken into account when designing such a mission, which specifically arise when observing in the wavelength range 25-400µm. In particular, attention is given to the following: how to best carry out high angular resolution interferometry using multiple telescopes; how to ensure the reliable and stable operation of a FIR instrument, used for both imaging and spectroscopy and how to avoid the contamination of the detected signal, caused by the self-emission of quasi-optical components at cryogenic temperatures. Firstly, the problem of designing and building a focal-plane interferometer is analysed both indirectly, through simulations of sparse-aperture systems, and directly, by carrying out feasibility studies with two optical experiments, designed to evaluate different technologies needed for its construction. Secondly, the design and build of a spectral-spatial calibration source for a far-IR, double-Fourier interferometer, is discussed. In particular, different suitable materials are reviewed by analysing their optical and thermal properties, through literature review and laboratory measurements. Then, two designs are described, by discussing their material composition and by carrying out finite-element simulations. Finally, the issues that can arise from the use of large, polymer-based, quasi-optical components, is analysed, in the context of cryogenic space applications. Specifically, the effect of their heating, and consequent re-irradiation at longer wavelength, is studied in the case of an instrument that operates on board a far-infrared space observatory and a sub-mm probe. In particular, a cryogenic model of the thermal and optical properties of these components is created and used to quantify this effect through finite-element analysis

End to end optical design and wavefront error simulation of METIS

We present the preliminary optical design of METIS, the Mid-infrared E-ELT Imager and Spectrograph, and study the end-to-end performance regarding wavefront errors and non-common path aberrations. We discuss the results of the Monte Carlo simulations that contain the manufacturing and alignment errors of the opto-mechanical system. We elaborate on the wavefront error budget of the instrument detailing all contributors. We investigate the mid and high spatial frequency errors of the optical surfaces, which we model using simulated surface height errors maps of one dimensional Power Spectral Density (PSD) functions

The calibration unit of the mid-infrared E-ELT instrument METIS

We present the preliminary design of the calibration unit of the future E-ELT instrument METIS. This independent subunit is mounted externally to the main cryostat of METIS and will function both as calibration reference for science observations, as well as verification and alignment tool during the AIT phase. In this paper, we focus on describing its preliminary layout and foreseen functionalities, based on the performance requirements defined at system level and the constraints imposed by warm IR background. We discuss the advantage of employing an integrating sphere as common radiation emitter, leading to a novel and versatile design, where the source's spatio-spectral properties can be varied with high fidelity and repeatability. By combining only few tuneable sources and mechanisms we show how a large instrument such as METIS can be calibrated and tested, without the need of a complex cold calibration unit

Status of the mid-IR ELT imager and spectrograph (METIS)

The Mid-Infrared ELT Imager and Spectrograph (METIS) is one of three first light instruments on the ELT. It will provide high-contrast imaging and medium resolution, slit-spectroscopy from 3 - 19um, as well as high resolution (R 100,000) integral field spectroscopy from 2.9-5.3µm. All modes observe at the diffraction limit of the ELT, by means of adaptive optics, yielding angular resolutions of a few tens of milliarcseconds. The range of METIS science is broad, from Solar System objects to active galactic nuclei (AGN). We will present an update on the main science drivers for METIS: circum-stellar disks and exoplanets. The METIS project is now in full steam, approaching its preliminary design review (PDR) in 2018. In this paper we will present the current status of its optical, mechanical and thermal design as well as operational aspects. We will also discuss the challenges of building an instrument for the ELT, and the required technologies