DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD AND RP-HPLC METHOD FOR ESTIMATION OF CAPECITABINE IN BULK AND TABLET DOSAGE FORMS

Objective: The objective of the present work is to develop and validate a novel, specific, precise and reliable method for estimation of Capecitabine in bulk and pharmaceutical dosage form using UV-visible spectroscopy and RP-HPLC method. Methods: UV-visible spectrophotometric determination was performed with Elico double beam SL 210 UV-visible spectrophotometer having deuterium lamp at λmax 304 nm using water as a medium. Linearity was noted over a concentration range of 2-20 µg/ml with a correlation coefficient of 0.99. HPLC analysis was performed using Eclipse XDB C18 column with 5 µm particle size having dimensions 4.6 X 250 mm column, Agilent 1260 infinity DAD detector, 1260 infinity quaternary pump using Ezchrome software at a flow rate of 1 ml/min and a run time pressure of 2140 psi. Methanol: acetonitrile: water in the ratio 30: 30: 40 was used as mobile phase and the effluents were analyzed at 304 nm. Both the proposed methods were validated for various parameters like linearity, precision, accuracy, robustness, ruggedness, selectivity, detection, quantification limits, formulation analysis as per International Conference on Harmonization (ICH) guidelines. Results: Linearity for UV and HPLC method was noted over a concentration range of 2-100 µg/ml with a correlation coefficient of 0.99. The retention time was considered to be 4.60 min. The % RSD for interday and intraday precision studies and recovery analysis of both UV and HPLC methods was found to be less than 1% which is less than the official RSD limit (2%). Recovery analysis performed using marketed formulation capeguard was considered to be greater than 99% for both the methods. Conclusion: Both the methods developed were validated according to the ICH guidelines. Hence it was evident that the developed methods were novel, sensitive, precise and reliable for estimation of Capecitabine in bulk and were successfully applied for estimation of pharmaceutical dosage forms. Keywords: Capecitabine, UV-visible spectroscopic method, HPLC method, Validatio

Tensile and Wear Behavior of Calotropis Gigentea Fruit Fiber Reinforced Polyester Composites

AbstractAn experimental study has been carried out to investigate the tensile and wear characterization of polymer composites made by reinforcing Calotropis Gigentea fruit fiber as a new natural fiber into a polyester resin. The Calotropis Gigentea fibres extracted by manual processes have been used to fabricate the composites. The composites are fabricated up to a maximum volume fraction of fibre of 0.35. The tensile strength increased with increase in fiber content. Further, the wear behavior of the Calotropis Gigentea fruit fiber composite were studied with increase in fiber content

Quark-Lepton Quartification

We propose that quarks and leptons are interchangeable entities in the high-energy limit. This naturally results in the extension of [SU(3)]^3 trinification to [SU(3)]^4 quartification. In addition to the unbroken color SU(3)_q of quarks, there is now also a color SU(3)_l of leptons which reduces to an unbroken SU(2)_l. We discuss the natural occurrence of SU(2)_l doublets at the TeV energy scale, which leads remarkably to the unification of all gauge couplings without supersymmetry. Proton decay occurs through the exchange of scalar bosons, with a lifetime in the range 10^{34} - 10^{36} years.Comment: 12 pages, 4 figures. Reference adde

Designing a Biosensor Using a Photonic Quasi-Crystal Fiber with Fan-shaped Analyte Channel

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RESEARCH ON AYURVEDA DRUGS TOWARDS THE DRUG DEVELOPMENT FOR PLASMODIUM VIVAX MALARIA

Developing countries are more vulnerable to the Vector borne diseases, than developed countries. Incidence of Malaria is steadily increasing and number of deaths as well; is a serious problem in Africa; every five (20%) childhood deaths are due to the effects of the disease and every 30 seconds a child dies from malaria. The problem of Malaria acquired new dimensions such as resistance of vectors to chemical insecticides and drug resistance in strains of Plasmodium Vivax and Plasmodium Falciparum. These are the serious obstacles in the control of Malaria and hence there is a serious need to develop alternate strategies to control Malaria.Central Council for Research in Ayurvedic Sciences is carrying out clinical trial on different Vector Borne Diseases like Malaria, Filariasis etc since seventies. Trial carried out with herbal and herbo-mineral drugs like AYUSH-64, Saptaparnatwak ghanavati, Guduci satva, Spatika Bhasma, Kiratatiktadi compound, Parijatapatra ghanavati etc. on Plasmodium Vivax Malaria. The present paper deals with the details of those drugs and concludes the best drug for control of Malaria

Eliminating the d=5 proton decay operators from SUSY GUTs

A general analysis is made of the question whether the d=5 proton decay operators coming from exchange of colored Higgsinos can be completely eliminated in a natural way in supersymmetric grand unified models. It is shown that they can indeed be in SO(10) while at the same time naturally solving the doublet-triplet splitting problem, having only two light Higgs doublets, and using no more than a single adjoint Higgs field. Accomplishing all of this requires that the vacuum expectation value of the adjoint Higgs field be proportional to the generator I_{3R} rather than to B-L, as is usually assumed. It is shown that such models can give realistic quark and lepton masses. We also point out a new mechanism for solving the \mu problem in the context of SO(10) SUSY GUTs.Comment: 24 pages in LaTeX, with 3 figure

4-Bromo-3-{N-[2-(3,4-dimethoxy­phen­yl)eth­yl]-N-methyl­sulfamo­yl}-5-methyl­benzoic acid monohydrate

In the title compound, C19H22BrNO6S·H2O, the dihedral angle between the planes of the two benzene rings is 3.1 (1)°. These rings are stacked over one another with their centroids separated by 3.769 (2) Å, indicating weak π–π inter­actions. In the crystal structure, mol­ecules are linked by O—H⋯O and O—H⋯(O,O) hydrogen bonds involving the water mol­ecule, forming a two-dimensional network parallel to (001)

A questionnaire base survey on the knowledge, attitude and practices about antimicrobial resistance and usage among the faculty and resident doctor of teaching tertiary care hospital, Chittoor, India

Background: 10million could die every year due to antibiotic resistant infections by 2050 unless the threat is addressed. Irrational use of antibiotic use is a global phenomenon. So, 50% all anti bionics are prescribed, sold are dispensed inappropriately, while 50% of patients are not taking antibiotics correctly (WHO 2004).Methods: This was a cross section study it was a conducted in RVS institute, tertiary care teaching hospital. Chittoor. The questionnaire was distributed along the faculty resident doctors and senior faculty of this RVS institute Where their knowledge, attitude, practice regarding antibiotic prescription and resistance was assessed by a five point likert scale, whose response ranged from strongly agree to disagree. Some questionnaire were of useful or nor useful and yes or no.Results: Irrational prescription of antibiotics is worldwide problem and also in India was known to most of the physicians in our institute (n=95%) of participants. 80% subjects answered that prescription writing influenced by senior faculty and medical representatives. 50% subjects answered that antimicrobial resistance is a problem in daily practice.80 % subjects answered that most of the antibiotics available as over the counter drugs (OTC).Conclusions: This study concludes, prescription writing influences by senior faculty and medical representatives. It’s important to monitor and auditing prescription writing based on WHO Antibiotic guidelines to prevent resistance. Strict vigilance of OTC sales of antibiotics to prevent resistance