8 research outputs found
Accelerating Universe from Extra Spatial Dimension
We present a simple higher dimensional FRW type of model where the
acceleration is apparently caused by the presence of the extra dimensions.
Assuming an ansatz in the form of the deceleration parameter we get a class of
solutions some of which shows the desirable feature of dimensional reduction as
well as reasonably good physical properties of matter. Interestingly we do not
have to invoke an extraneous scalar field or a cosmological constant to account
for this acceleration. One argues that the terms containing the higher
dimensional metric coefficients produces an extra negative pressure that
apparently drives the inflation of the 4D space with an accelerating phase. It
is further found that in line with the physical requirements our model admits
of a decelerating phase in the early era along with an accelerating phase at
present.Further the models asymptotically mimic a steady state type of universe
although it starts from a big type of singularity. Correspondence to Wesson's
induced matter theory is also briefly discussed and in line with it it is
argued that the terms containing the higher dimensional metric coefficients
apparently creates a negative pressure which drives the inflation of the
3-space with an accelerating phase.Comment: 0
Deliberative Context-Aware Ambient Intelligence System for Assisted Living Homes
Monitoring wellbeing and stress is one of the problems covered by ambient
intelligence, as stress is a significant cause of human illnesses directly
affecting our emotional state. The primary aim was to propose a deliberation
architecture for an ambient intelligence healthcare application. The
architecture provides a plan for comforting stressed seniors suffering from
negative emotions in an assisted living home and executes the plan considering
the environment's dynamic nature. Literature was reviewed to identify the
convergence between deliberation and ambient intelligence and the latter's
latest healthcare trends. A deliberation function was designed to achieve
context-aware dynamic human-robot interaction, perception, planning
capabilities, reactivity, and context-awareness with regard to the environment.
A number of experimental case studies in a simulated assisted living home
scenario were conducted to demonstrate the approach's behavior and validity.
The proposed methods were validated to show classification accuracy. The
validation showed that the deliberation function has effectively achieved its
deliberative objectives
A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M1 receptor agonist HTL0018318 in patients with mild-to-moderate Alzheimer's disease.
Funder: Allergan Incorporated (now AbbVie)INTRODUCTION: This study examined the safety and pharmacodynamic effects of selective muscarinic M1 receptor orthosteric agonist HTL0018318 in 60 patients with mild-to-moderate Alzheimer's disease (AD) on background donepezil 10Â mg/day. METHODS: A randomized, double-blind, placebo-controlled 4-week safety study of HTL0018318Â with up-titration and maintenance phases, observing exploratory effects on electrophysiological biomarkers and cognition. RESULTS: Treatment-emergent adverse events (TEAEs) were mild and less frequently reported during maintenance versus titration. Headache was most commonly reported (7-21%); 0 to 13% reported cholinergic TEAEs (abdominal pain, diarrhea, fatigue, nausea) and two patients discontinued due to TEAEs. At 1 to 2 hours post-dose, HTL0018318-related mean maximum elevations in systolic and diastolic blood pressure of 5 to 10Â mmHg above placebo were observed during up-titration but not maintenance. Postive effects of HTL0018318 were found on specific attention and memory endpoints. DISCUSSION: HTL0018318 was well tolerated in mild-to-moderate AD patients and showed positive effects on attention and episodic memory on top of therapeutic doses of donepezil
Fear of Self-Injecting and Self-Testing and the Related Risk Factors in Adolescents with Type 1 Diabetes: A Cross-Sectional Study
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