MULTICOMPLICATED MYOCARDIAL INFARCTION

The clinical course of myocardial infarction frequently burdened by a variety of complications, which largely determine its scenario and prognosis. Despite advances in the management of this disease, complications can and do occur. These dangers arise from two principal sources: on the one hand, from the local effects of the lesion and the circulatory depression that follows, and, on the other, from the hazards that may attend during active treatment. On example of clinical case is demonstrated severe course of myocardial infarction with development of multiple complications at different stages, but, ultimately, with a favorable outcome. Early, aggressive, and judicious treatment of these complications may substantially decrease the morbidity and mortality associated with this disease

ACUTE PERICARDITIS ON EXAMPLE OF ILLUSTRATIVE CLINICAL CASE

Pericarditis is an important diagnosis to consider in a patient presenting with chest pain. This article describes the common features and management of pericarditis in the general practice setting on the example of clinical case. To the cardiologic department was admitted middle aged male. He complained of sharp retrosternal pain, and fever. The survey revealed distinctive features of pericarditis: pericardial friction rub on auscultation, diffuse PR segment depressions on ECG, pericardial effusion on echocardiography, but etiology was not elicit. Most cases are labeled as «idiopathic» because the traditional diagnostic approach often fails to identify the etiology. The presence of febrile fever and neutrophilic leukocytosis indicates that a bacterial etiology take place. Prompt antibacterial and anti-inflammatory treatment led to recovery of the patient. He was completely free of symptoms and had returned to his pre-morbid state

ANTISYNTHETASE SYNDROME: COURSE OF A RARE DISEASE ON EXAMPLE OF CLINICAL CASE

Systemic disorders of connective tissue refer to rare and poorly studied diseases. This group of diseases associated with the variable course and makes it interesting for either medical scientists and researchers or practitioner. Herein we report a case of antisynthetase syndrome with interstitial lung disease complicated by pulmonary thromboembolism. The patient is 71 year old female, who suffered from severe dyspnea, dry cough, intermittent wheezing. Also she had dry eyes, dry mouth, muscle weakness and intermittent pain in large joints, and low grade fever. Physical examination revealed a characteristic heliotrope eye rash, V sign, «mechanic’s hand», peripheral muscles atrophy, dry eyes and mouth, fine crackles to auscultation in basal parts of lungs, soft S1 and S2 heart sounds. Her biochemical profile showed increased creatinekinase, LDH, AsAT, and AlAT Her immunology results were positive to ANA, anti-ds-DNA, anti-ss-A, anti-ss-B and anti- Jo-1 autoantibodies. Based on the obtained data, antisynthetase syndrome was established. It was detected, that progressive dyspnea had been caused by interstitial lung disease and pulmonary thromboembolism. It was confirmed by chest CT-scan and pulmonary angiography. Treatment in this case is mainly symptomatic. It was prescribed glucocorticoids, immunosuppressant, and anticoagulants. This case illustrates the course of the antisynthetase overlap syndrome and difficulties of it management due to the lack of treatment standards and reliable data of the medicine effectiveness

Особенности состояния органов гастродуоденальной и гепатобилиарной зон при ограниченной склеродермии у детей на современном этапе

Мета дослідження — вивчити частоту, вираженість та особливості патологічних змін гастродуоденальної (ГДЗ) і гепатобіліарної (ГБЗ) зон при обмеженій склеродермії (ОСД) у дітей.Results of examination of digestive organs in 66 children suffering from limited sclerodermia are presented. The comparative analysis of the functional state of gastroduodenal and hepatobiliary organs was carried out. A considerable incidence rate of their lesion was revealed (75,8 %).Представлены результаты исследования органов пищеварения 66 детей, больных ограниченной склеродермией. Проведен сравнительный анализ состояния органов гастродуоденальной и гепатобилиарной систем. Выявлена значительная частота их поражения (75,8 %)

Global Spore Sampling Project: A global, standardized dataset of airborne fungal DNA

Novel methods for sampling and characterizing biodiversity hold great promise for re-evaluating patterns of life across the planet. The sampling of airborne spores with a cyclone sampler, and the sequencing of their DNA, have been suggested as an efficient and well-calibrated tool for surveying fungal diversity across various environments. Here we present data originating from the Global Spore Sampling Project, comprising 2,768 samples collected during two years at 47 outdoor locations across the world. Each sample represents fungal DNA extracted from 24 m3 of air. We applied a conservative bioinformatics pipeline that filtered out sequences that did not show strong evidence of representing a fungal species. The pipeline yielded 27,954 species-level operational taxonomic units (OTUs). Each OTU is accompanied by a probabilistic taxonomic classification, validated through comparison with expert evaluations. To examine the potential of the data for ecological analyses, we partitioned the variation in species distributions into spatial and seasonal components, showing a strong effect of the annual mean temperature on community composition