Clinical Features and Pattern of Presentation of Breast Diseases in Surgical Outpatient Clinic of a Suburban Tertiary Hospital in South-West Nigeria

Objective: To characterize the clinical features and pattern of presentation of breast diseases as observed in our practice. Materials and Methods: A prospective study of 121 consecutive patients with breast complaints presenting in our Surgical Outpatient Clinics. The relevant data were collected by two surgeons using the prescribed forms and was analyzed using Epi Info 2003, Mann–Whitney (test of two groups) Chi-squared and Fishers exact test was used to compare parameters of benign and malignant groups. P value <0.05 was considered as significant. Results: One hundred and nineteen patients were females, two were males. The age range was 14–70 years. Forty two (34.7%) patients were in the 21–30 year age group. The commonest symptoms were breast lump in 111 (91.7%) patients, and breast pain in 28 (23.1%) patients. Breast pain was a significant presenting complaint in patients with breast malignancy (P=.026). On clinical examination 103 (85.1%) patients had palpable lumps, and seven patients were normal. Forty four patients (36.3%) had malignant disease, seventy patients (57.8%) had benign breast diseases and seven were normal. Fifty nine of the 70 benign diseases were fibroadenoma. One hundred and three patients (85%) had appropriate therapy, while 18 patients (14.8%), including eight with malignant disease absconded. Conclusion: In the study, a breast lump was the commonest clinical feature of breast disease. Over 60% of these were benign. Breast pain was a statistically significant presentation in patients with malignant breast disease. One in seven of the patients absconded.Keywords: Breast lumps, breast malignancy, breast pain, fibroadenomaNigerian Journal of Surgery, Jan-Jun 2012 | Volume 18 | Issue

Comparative evaluation of processes for production of soybean meal for poultry feed in Nigeria Evaluación comparativa de procesos para la producción de harina de soya para la alimentación de pollos en Nigeria

This work examined and compared three processes for production of low trypsin inhibitor soybean meal. Soybean flour was subjected to roasting, autoclaving and steaming to denature trypsin inhibitors. Roasting was done at 120, 130, 135 and 140 ºC for 5, 7, 8 and 9 minutes, respectively. Autoclaving was carried out at 121ºC, 15psig for 20, 30, 40 and 50 minutes. Steaming was carried out at 105 ºC for 10, 12, 15 and 18 minutes. Defatting of the samples was done and the activity of trypsin inhibitor was investigated. Proximate analysis and quality tests was carried out to ascertain quality of the heat treated soybean meals. Trypsin inhibitor in the soybean meals from the three heat treatment processes ranged from 1.20 to 3.54mg/g while that of raw sample was 6.01mg/g. Percentage crude protein in all the heat treated samples ranged from 39.38 to 40.58 % while that of raw sample was 44.60 %. Urease index ranged from 0.11 to 2.07 % for all heat treated samples while it was 2.11 % for the raw samples. % KOH protein solubility in Soybean meal from the three processes ranged from 45.2 to 73.1 % while that of the raw sample was 49.1%. The results were statistically significant at p>0.05. At significance level of p>0.05 it was established that local soybeans can be processed with adequate heat to obtain low activity soybean meal with good nutrient standard. The steaming process operated at 105 ºC for 18 minutes gave the best overall results with trypsin inhibitor activity of 1.20 mg/g

Effect of Substitution of Bovine Rumen Epithelial Tissue Scrapings for Fishmeal on the Growth Performance, Nutrient Utilization and Carcass Characteristics of Broiler Chickens

. An eight-week feeding trial was conducted to evaluate the performance, nutrient utilization and carcass characteristics of broiler chickens fed varied levels of bovine rumen epithelial tissue scrapings (BRETS) in replacement for fish meal at 0, 50 and 100% levels of substitution. Fifty four birds were used for the study and the birds were randomly distributed into three (3) dietary treatments which were randomly assigned to the rations. Feed and water were supplied ad libitum and data were collected on the feed intake, weight gain, feed conversion ratio and nutrient utilization. Data were also collected on the carcass characteristics after some birds had been slaughtered at the end of the experiment. Data collected were subjected to one-way analysis of variance and significant differences were indicated using Duncan multiple range test to separate the means. Results indicated that there was significant difference (P0.05) in the weight gain, heart and lung weights. It was concluded that up to 50% BRETS inclusion as substitute for fish meal protein could be employed without any adverse effect, to maintain the quality of the broiler chicken while minimizing the high cost of whole fishmeal since BRETS is an abattoir by-product that is readily available locally

Anthropometric studies for designing to fit gari-frying workers

 Work system and product design require anthropometric data of the user population relevant to the facility in order to have safe operation in service as well as increase user satisfaction and efficiency. Designing to fit gari-frying workers in each of the southwestern states in Nigeria is geared towards this end. The age, weight and twenty-five body dimensions of 120 gari-frying workers in Lagos, Ogun, Oyo, Osun, Ondo and Ekiti, selected by random sampling, were measured. The body dimensions include stature, shoulder height, sitting height, eye height, forward grip reach, buttock-popliteal height, buttock-knee length, knee height, thigh clearance, forearm-to-forearm breadth, waist depth, elbow rest height, knuckle height, elbow grip length, hip breadth, hand length, hand breadth, hand thickness, grip span and lumbar height. SPSS 20 software was used to perform statistical analysis to determine the mean, standard deviation, minimum and maximum values, 2nd, 5th, 25th, 50th, 75th and 95th percentiles for each state. Ogun state was used as a control, against which means of body dimension data, collected from other states, were compared using paired sample t-test. The results revealed that some of the body dimensions showed significant difference across the states at P≤0.05 with Oyo having more anthropometric parameters that differ from that of Ogun and Ondo having the least. Between 11.42% and 24.25% difference in the mean age, weight and lumbar height was observed in all the states. Osun state has the highest mean BMI and BSA values of 32.38 kg/m2 and 1.82 m2, respectively. These results are the required data for the design of facility and products for gari-frying workers as well as in similar women workspaces, especially in processing centres

Reference values of haematological parameters of healthy adults in the north central zone of Nigeria

Background: Haematological parameters differ from one population to another due to several factors. To determine the clinical implication of the blood parameters of an individual in the state of health or disease, we need to have the knowledge of the normal reference range for that locality.Objectives: To determine the reference values of haematological parameters of apparently healthy adults in Ilorin.Design: A descriptive cross sectional study.Setting: Ilorin, North Central zone of NigeriaSubjects: Nine hundred and ten (443 males and 467 females) randomly selected normal, HIV negative individuals aged 18-65 yearsResults: The red blood cell count, Haemoglobin concentration, PCV and MCHC were significantly higher among males than females while the platelet count, total WBC count and absolute neutrophil count were significantly higher in females than in males. There was however no significant gender difference in the values of MCV, MCH and absolute lymphocyte count. The normal reference values obtained in this study were notably different from those that are used currently in the hospital.Conclusion: The normal reference value obtained in this study was notable different from those that are currently used in the hospital. These findings will have clinical implications regarding the adjustment of our current reference values and definitely add value to the management of patients in this part of the country

Clinicopathological and molecular characteristics of Ku 70/80 expression in Nigerian breast cancer and its potential therapeutic implications

Ku 70/80 is a regulator of the Non-Homologous End Joining (NHEJ) roles in clinicopathological features, and has prognostic significance in breast cancer (BC) in Caucasian populations. However, its significance in the Nigerian BC population, which is characterized by a higher rate of the triple-negative and basal phenotype, p53 mutation rate and BRCA1 deficiency, still needs to be investigated. We hypothesize that Ku70/80 expression shows adverse expression in Nigerian BC and, furthermore, that it is likely to have a therapeutic implication for Black BC management.This study investigated the biological, clinicopathological and prognostic significance of Ku 70/80 expression in a BC cohort from a Nigerian population. Ku 70/80 expression was determined in 188 well-characterized formalin-fixed, paraffin-embedded (FFPE) BC samples using tissue microarray and immunohistochemistry. Ku 70/80 expression was correlated with clinicopathological, molecular and prognostic characteristics of patients.Ku 70/80 was expressed in 113 (60.1%) tumors, and was positively associated with metastatic disease, triple-negative and basal phenotype, BRCA1 down regulators (MTA-1 and ID4), p-cadherin, PI3KCA and p53 expression. It inversely correlated with BRCA1, BRCA2, BARD1 and p27. Ku 70/80 was predictive of breast cancer-specific survival in multivariate analysis, but not of disease-free interval.This study demonstrated that Ku 70/80 expression is associated with triple negativity and down-regulation of the homologous recombination pathway of DNA repair. Therefore, the development of novel drugs to target KU70/80 may improve the patients’ outcome in the treatment of Black BC

The chest radiographs of suspected and confirmed HIV/AIDS patients - pattern of radiological features in Ilorin

No Abstract. Tropical Journal of Health Sciences Vol. 15 (1) 2008: pp. 71-7