Hereditary spherocytosis.

Hereditary spherocytosis (HS) is a familial hemolytic disorder with marked heterogeneity of clinical features, ranging from an asymptomatic condition to a fulminant hemolytic anemia. Although a positive family history of spherocytosis increases the risk for this disorder, it may be sporadic in some cases. In severe cases the disorder may be detected in early childhood, but in mild cases it may go unnoticed until later in adult life. A 27-year-old Nigerian woman presented with mild anemia, jaundice, splenomegaly and a history of multiple blood transfusion. Blood film showed about 70% spherocytes,reticulocytosis of 6.5%, increased osmotic fragility test and a negative direct antiglobulin test. She was managed conservatively on nutritional supplements and a significant regression of symptoms after 6 months was achieved

Zidovudine induced pure red cell aplasia: A case report

No Abstract

Spleenic lymphoma villous lymphocytes: Case report and literature review

ABSTRACT BACKGROUND: Splenic lymphoma with villous lymphocytes (SLVL) is a rare but recognized distinct disease entity among chronic B lymphoproliferative disorders. It is frequently misdiagnosed as chronic lymphocytic leukaemia, (CLL) Prolymphocytic leukaemia or Hairy Cell leukaemia. Few cases have been reported worldwide. METHOD: The case records of a sixty year old Nigerian male with a splenic lymphoma and a review of the literature on the subject using MEDLINE, other internet sources and manual library search was utilized. RESULT: A sixty-year-old male with splenic lymphoma with villous lymphocytes, seen at the Ahmadu Bello University Teaching Hospital Zaria is presented. However review of the blood film, bone marrow and Splenic aspirates showed absolute lymphocytosis, consisting of “villous” lymphocytes. He was commenced on an alkylating agent and a glucocorticoid, with partial remission in the first three months but was lost to follow up.CONCLUSION: Adequate morphologic evaluation is advocated particularly in the resource limited settings were Cytogenetics, immunohistochemistry and immunophenotyping are not available. Nigerian Journal of Medicine Vol. 16 (1) 2007: pp. 71-7

The pattern of distribution of ABO blood groups in North Western Nigeria

Background: Everybody over the age of about six months has clinically significant anti-A or Anti-B in their serum, if they lack the corresponding antigens on their red cells. ABO blood group antigens are the most important in blood transfusion services. This study was to determine the current incidence of ABO blood group system in our environment. Methods: Hospital records were reviewed on blood groups of Donors, from the blood donor centers of Ahmadu Bello University Teaching Hospital Kaduna unit. This was done over a period of five years from January 2000 to December 2004. Blood group determination was by serological technique. Result: Twelve thousand five hundred and eighty nine patients blood group were reviewed. The frequencies of the ABO blood group system was found to be 21.3 percent for group A, 24.3 percent for group B, 5.2 percent for group AB and 49.2 percent for blood group O.Conclusion: Blood group O is the most frequently encountered blood group in this environment while AB blood group is the least. Group specific transfusion is still advocated despite the concept of universal donor (group O) and universal recipient (group AB), which is now obsolete. Keywords: ABO, blood group, antigens, group specific transfusion Annals of Nigerian Medicine Vol. 1(2) 2005: 17-1

Prevalence of Lupus Anticoagulant in Women with Spontaneous Abortion in Zaria

Introduction: Spontaneous abortion (SA) is a common complication of pregnancy. Presence of lupus anticoagulant (LA), one of the antiphospholipid antibodies, has been associated with SA in many studies, especially in Caucasians. This study was carried out to determine the prevalence of LA in women with SA in ABUTH, Zaria. Materials and Methods: A cohort of 100 consecutive women presenting with SA with no history of thrombotic episodes were enrolled into the study. Prothrombin time (PT), kaolin clotting time (KCT), and activated partial  hromboplastin time (APTT) were conducted on samples of all the participants. Eight patients had prolonged APTT, and after a 50:50 mixture of their plasma with pooled control plasma, four (50%) had uncorrected APTT. Staclot® (a hexagonal‑phase phospholipid) test and calculated Rosner index for prolonged KCT were used for the confirmation of LA in samples with uncorrected APTT after mixing studies. Results: We analyzed 100 women with one or more SA with a mean age of 31.0 ± 3.8 years. Nearly 4% and 3% of the participants were LA positive with Staclot® and KCT tests, respectively. Patients with LA were more likely to have had a past history of preeclampsia/eclampsia, small for gestational age deliveries, and previous SA (prevalence odds ratio [95% confidence interval]) of 1.9 (0.2, 20.1), 3.2 (0.3, 34.3), and 1.4 (0.1–13.6), respectively. The PT, APTT, and KCT were significantly prolonged in patients with LA (P ≤ 0.001 for each, respectively). Conclusion: LA may be one of the causes of SA and other adverse pregnancy outcomes such as preeclampsia/eclampsia and small for date deliveries. It is recommended that patients with prolonged APTT, uncorrected with 50:50 mixing study with pooled control plasma, should be evaluated further for LA.Keywords: Lupus anticoagulant, spontaneous abortion, uncorrected activated partial thromboplastin tim

Juvenile myelodysplastic syndrome in a Nigerian child-a case report and review of literature

No Abstract. Highland Medical Research Journal Vol. 3(2) 2005: 149-15

The incidence of HIV among blood donors in Kaduna, Nigeria

No Abstract. African Health Science Vol. 8 (1) 2008: pp. 60-6

The incidence of HIV among blood donors in Kaduna, Nigeria

No Abstract. African Health Science Vol. 8 (1) 2008: pp. 60-6