Effect of Estrogen on Musculoskeletal Performance and Injury Risk.

Estrogen has a dramatic effect on musculoskeletal function. Beyond the known relationship between estrogen and bone, it directly affects the structure and function of other musculoskeletal tissues such as muscle, tendon, and ligament. In these other musculoskeletal tissues, estrogen improves muscle mass and strength, and increases the collagen content of connective tissues. However, unlike bone and muscle where estrogen improves function, in tendons and ligaments estrogen decreases stiffness, and this directly affects performance and injury rates. High estrogen levels can decrease power and performance and make women more prone for catastrophic ligament injury. The goal of the current work is to review the research that forms the basis of our understanding how estrogen affects muscle, tendon, and ligament and how hormonal manipulation can be used to optimize performance and promote female participation in an active lifestyle at any age

Diagnostic Adjudication in Appellate Courts: The Supreme Court of Canada and the Charter of Rights

Three distinct adjudicatory processes are found in appellate courts: decisional adjudication (applying principles), procedural adjudication (choosing among principles), and diagnostic adjudication (defining and developing principles). The Supreme Court of Canada has traditionally used procedural adjudication, in which the adversary process frames issues and generates supporting material. However, the Court\u27s decreased caseload, its increased discretion to select cases, and the arrival of a new wave of issues under the Charter of Rights has shifted the Court\u27s work to diagnostic adjudication. As judgment becomes less a choice problem and more a creative exercise, both the degree and kind of judicial involvement changes. Thusfar, however, the Court\u27s administrative responses to the pressure of its work have had limited success. To be effective, reforms in the way the Court organizes and processes its work must derive from an analysis of the requirements of diagnostic adjudication. The paper concludes by suggesting an overall approach and making specific proposals

Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model.

In vitro experiments are essential to understand biological mechanisms; however, the gap between monolayer tissue culture and human physiology is large, and translation of findings is often poor. Thus, there is ample opportunity for alternative experimental approaches. Here we present an approach in which human cells are isolated from human anterior cruciate ligament tissue remnants, expanded in culture, and used to form engineered ligaments. Exercise alters the biochemical milieu in the blood such that the function of many tissues, organs and bodily processes are improved. In this experiment, ligament construct culture media was supplemented with experimental human serum that has been 'conditioned' by exercise. Thus the intervention is more biologically relevant since an experimental tissue is exposed to the full endogenous biochemical milieu, including binding proteins and adjunct compounds that may be altered in tandem with the activity of an unknown agent of interest. After treatment, engineered ligaments can be analyzed for mechanical function, collagen content, morphology, and cellular biochemistry. Overall, there are four major advantages versus traditional monolayer culture and animal models, of the physiological model of ligament tissue that is presented here. First, ligament constructs are three-dimensional, allowing for mechanical properties (i.e., function) such as ultimate tensile stress, maximal tensile load, and modulus, to be quantified. Second, the enthesis, the interface between boney and sinew elements, can be examined in detail and within functional context. Third, preparing media with post-exercise serum allows for the effects of the exercise-induced biochemical milieu, which is responsible for the wide range of health benefits of exercise, to be investigated in an unbiased manner. Finally, this experimental model advances scientific research in a humane and ethical manner by replacing the use of animals, a core mandate of the National Institutes of Health, the Center for Disease Control, and the Food and Drug Administration

Strong Structural Controllability of Systems on Colored Graphs

This paper deals with structural controllability of leader-follower networks. The system matrix defining the network dynamics is a pattern matrix in which a priori given entries are equal to zero, while the remaining entries take nonzero values. The network is called strongly structurally controllable if for all choices of real values for the nonzero entries in the pattern matrix, the system is controllable in the classical sense. In this paper we introduce a more general notion of strong structural controllability which deals with the situation that given nonzero entries in the system's pattern matrix are constrained to take identical nonzero values. The constraint of identical nonzero entries can be caused by symmetry considerations or physical constraints on the network. The aim of this paper is to establish graph theoretic conditions for this more general property of strong structural controllability.Comment: 13 page

Correctly defined concrete syntax

Due to their complexity, the syntax of modern modeling languages is preferably defined in two steps. The abstract syntax identifies all modeling concepts whereas the concrete syntax should clarify how these concepts are rendered by graphical and/or textual elements. While the abstract syntax is often defined in form of a metamodel, there does not exist such standard format yet for concrete syntax definitions. The diversity of definition formats—ranging from EBNF grammars to informal text—is becoming a major obstacle for advances in modeling language engineering, including the automatic generation of editors. In this paper, we propose a uniform format for concrete syntax definitions. Our approach captures both textual and graphical model representations and even allows to assign more than one rendering to the same modeling concept. Consequently, following our approach, a model can have multiple, fully equivalent representations, but—in order to avoid ambiguities when reading a model representation—two different models should always have distinguishable representations. We call a syntax definition correct, if all well-formed models are represented in a non-ambiguous way. As the main contribution of this paper, we present a rigorous analysis technique to check the correctness of concrete syntax definition