Norovirus Infection and Disease in an Ecuadorian Birth Cohort: Association of Certain Norovirus Genotypes With Host FUT2 Secretor Status.

BACKGROUND: Although norovirus is the most common cause of gastroenteritis, there are few data on the community incidence of infection/disease or the patterns of acquired immunity or innate resistance to norovirus. METHODS: We followed a community-based birth cohort of 194 children in Ecuador with the aim to estimate (1) the incidence of norovirus gastroenteritis from birth to age 3 years, (2) the protective effect of norovirus infection against subsequent infection/disease, and (3) the association of infection and disease with FUT2 secretor status. RESULTS: Over the 3-year period, we detected a mean of 2.26 diarrheal episodes per child (range, 0-12 episodes). Norovirus was detected in 260 samples (18%) but was not found more frequently in diarrheal samples (79 of 438 [18%]), compared with diarrhea-free samples (181 of 1016 [18%]; P = .919). A total of 66% of children had at least 1 norovirus infection during the first 3 years of life, and 40% of children had 2 infections. Previous norovirus infections were not associated with the risk of subsequent infection. All genogroup II, genotype 4 (GII.4) infections were among secretor-positive children (P < .001), but higher rates of non-GII.4 infections were found in secretor-negative children (relative risk, 0.56; P = .029). CONCLUSIONS: GII.4 infections were uniquely detected in secretor-positive children, while non-GII.4 infections were more often found in secretor-negative children

Superconducting Magnetic Heterostructured Components for Electric Motor Applications

Trapped flux magnets made by stacking high temperature superconducting tape portray an easy assembly with already available materials, high mechanical resistance, provided by the substrate and improved thermal stability, which enhances the trapped flux compared to bulks. This allowed reaching the world record of 17.7 T. The presented analysis expands previous work with wide superconducting tapes showing further pos-sible improvements in this kind of devices in order to be used as source of magnetic flux in electrical motors, substituting permanent magnets. The aims are to increase the trapped magnetic flux during magnetization and decrease the leakage flux at the edges of the magnet during the operation of the machine. This is expected to be achieved by either introducing new materials in-between the individual tapes, such as ferromagnetic layers, or modifying the composition of the substrate. The results of simulations using the H-formulation as well as experimental measurements are presented.EPSRC grant EP/P000738/

Mini-Cog for the diagnosis of Alzheimer's disease dementia and other dementias within a secondary care setting

© 2014 The Cochrane Collaboration. This is the protocol for a review and there is no abstract. The objectives are as follows: To determine the diagnostic accuracy of the Mini-Cog for detecting Alzheimer's disease dementia and related dementias in a secondary care setting. To investigate the heterogeneity of test accuracy in the included studies and potential sources of heterogeneity. These potential sources of heterogeneity will include the baseline prevalence of dementia in study samples, thresholds used to determine positive test results, the type of dementia (Alzheimer's disease dementia or all causes of dementia), and aspects of study design related to study quality. We will also identify gaps in the evidence where further research is required

A Tunable Two-impurity Kondo system in an atomic point contact

Two magnetic atoms, one attached to the tip of a Scanning Tunneling Microscope (STM) and one adsorbed on a metal surface, each constituting a Kondo system, have been proposed as one of the simplest conceivable systems potentially exhibiting quantum critical behaviour. We have succeeded in implementing this concept experimentally for cobalt dimers clamped between an STM tip and a gold surface. Control of the tip-sample distance with sub-picometer resolution allows us to tune the interaction between the two cobalt atoms with unprecedented precision. Electronic transport measurements on this two-impurity Kondo system reveal a rich physical scenario which is governed by a crossover from local Kondo screening to non-local singlet formation due to antiferromagnetic coupling as a function of separation of the cobalt atoms.Comment: 22 pages, 5 figure

Characterization of Smallholder Beef Cattle Production System in Central Vietnam –Revealing Performance, Trends, Constraints, and Future Development

The objective of this study is to evaluate the characteristics of smallholder beef cattle production in Central Vietnam. A total of 360 households were interviewed by using semi-structured questionnaire; a total of 606 beef cows were investigated for evaluating calving interval (CI). Thirty-two fattening cattle were monitored for the estimation of diet structure. Results showed that the cattle herd size was 4.32-4.45 cattle/household. In North Central (NC), 55% of surveyed farmers kept local cattle, 45% kept crossbreeds, and none of surveyed farmers keeping exotic breeds. In South Central (SC), 63% of surveyed farmers kept cross cattle, 32% kept local cattle, and 5% kept exotic breeds. In the breeding method, 70% of surveyed farmers used artificial insemination (AI), 20% used natural mating (NM), and only 10% used both AI and NM in SC, whereas in NC 40% of farmers used AI, 40% used NM, and 20% used both AI and NM. The variety of feedstuffs fed to cattle including roughages and concentrate. The concentrate in the diet for fattening cattle was 25%-35% and protein level was 11%-13%, and the average daily gain of cattle was 0.51-0.63 kg/day. The CI of cows was 12-13 months in SC, whereas in NC it was 13-14 months. There were numerous constraints to cattle production in surveyed households including diseases, lack of good quality feed sources, breeds, knowledge, and lack of capital. In conclusion, cattle production in Central Vietnam is small scale and still largely extensive. There are constraints that must be solved to improve livestock systems in the near future, especially when shifting towards semi-intensive and/or intensive cattle production systems.

Chemotactic response and adaptation dynamics in Escherichia coli

Adaptation of the chemotaxis sensory pathway of the bacterium Escherichia coli is integral for detecting chemicals over a wide range of background concentrations, ultimately allowing cells to swim towards sources of attractant and away from repellents. Its biochemical mechanism based on methylation and demethylation of chemoreceptors has long been known. Despite the importance of adaptation for cell memory and behavior, the dynamics of adaptation are difficult to reconcile with current models of precise adaptation. Here, we follow time courses of signaling in response to concentration step changes of attractant using in vivo fluorescence resonance energy transfer measurements. Specifically, we use a condensed representation of adaptation time courses for efficient evaluation of different adaptation models. To quantitatively explain the data, we finally develop a dynamic model for signaling and adaptation based on the attractant flow in the experiment, signaling by cooperative receptor complexes, and multiple layers of feedback regulation for adaptation. We experimentally confirm the predicted effects of changing the enzyme-expression level and bypassing the negative feedback for demethylation. Our data analysis suggests significant imprecision in adaptation for large additions. Furthermore, our model predicts highly regulated, ultrafast adaptation in response to removal of attractant, which may be useful for fast reorientation of the cell and noise reduction in adaptation.Comment: accepted for publication in PLoS Computational Biology; manuscript (19 pages, 5 figures) and supplementary information; added additional clarification on alternative adaptation models in supplementary informatio

Complete mitochondrial genome of the grey reef shark, Carcharhinus amblyrhynchos (Carcharhiniformes: Carcharhinidae)

We report the first mitochondrial genome sequences for the gray reef shark, Carcharhinus amblyrhynchos. Two specimens from the British Indian Ocean Territory were sequenced independently using two different next generation sequencing methods, namely short read sequencing on the Illumina HiSeq and long read sequencing on the Oxford Nanopore Technologies’ MinION sequencer. The two sequences are 99.9% identical and are 16,705 base pairs (bp) and 16,706 bp in length. The mitogenome contains 22 tRNA genes, two rRNA genes, 13 protein-coding genes and two non-coding regions; the control region and the origin of light-strand replication (OL)

One-loop Renormalization of Black Hole Entropy Due to Non-minimally Coupled Matter

The quantum entanglement entropy of an eternal black hole is studied. We argue that the relevant Euclidean path integral is taken over fields defined on $\alpha$-fold covering of the black hole instanton. The statement that divergences of the entropy are renormalized by renormalization of gravitational couplings in the effective action is proved for non-minimally coupled scalar matter. The relationship of entanglement and thermodynamical entropies is discussed.Comment: 17 pages, latex, no figure

Symbols of One-Loop Integrals From Mixed Tate Motives

We use a result on mixed Tate motives due to Goncharov (arXiv:alg-geom/9601021) to show that the symbol of an arbitrary one-loop 2m-gon integral in 2m dimensions may be read off directly from its Feynman parameterization. The algorithm proceeds via recursion in m seeded by the well-known box integrals in four dimensions. As a simple application of this method we write down the symbol of a three-mass hexagon integral in six dimensions.Comment: 13 pages, v2: minor typos correcte