581 research outputs found
Cigarette smoking and KRAS oncogene mutations in sporadic colorectal cancer: results from the Netherlands Cohort Study
Since a KRAS oncogene mutation is an early event in colorectal cancer development and cigarette smoking is thought to have an effect on early stages of colorectal tumorigenesis, smoking, especially long-term smoking, may be associated with the risk for colorectal cancer with KRAS oncogene mutations. In the Netherlands Cohort Study on diet and cancer (n=120,852 men and women), using a case-cohort design, adjusted incidence rate ratios (RR) and 95% confidence intervals (CI) were computed for colorectal tumors with wild-type and with mutated KRAS gene, and with specific G:C-->T:A or G:C-->A:T point mutations in KRAS, according to cigarette smoking status, frequency, duration, pack years, age at first exposure, years since cessation, inhalation and filter usage. After 7.3 years and excluding the first 2.3 years, 648 cases and 4083 sub-cohort members were included in the analyses. Ex-smokers, but not current smokers, were at increased risk for colorectal cancer with wild-type KRAS gene tumors when compared with never smokers, albeit not statistically significant (RR 1.26, 95% CI 0.96-1.66). This was not observed for KRAS mutated tumors when comparing ex-smokers with never smokers (RR 1.15, 95% CI 0.79-1.66). The highest category of smoking frequency (>20 cigarettes/day) and inhalation of smoke were associated with an increased risk for colorectal cancer with wild-type KRAS gene tumors, though not statistically significant, when compared with never smoking (frequency: RR 1.24, 95% CI 0.90-1.71 and inhalation: RR 1.25, 95% CI 0.94-1.67). These associations were strongest in men (ex-smokers: RR 1.79, 95% CI 1.00-3.20; frequency: RR 1.91, 95% CI 1.03-3.52; inhalation: RR 1.69, 95% CI 0.94-3.04). No associations were observed between any of the smoking characteristics and the risk for colorectal cancer with mutated KRAS gene tumors, nor where there any clear associations with tumors with specific G:C-->A:T transitions or G:C-->T:A transversions. These results suggest that, in contrast to the hypothesis, smoking does not increase the risk for colorectal tumors with a mutated KRAS gene. Some smoking characteristics, i.e. being an ex-smoker, frequency and inhalation, may be associated with risk for colorectal cancer characterized by the wild-type KRAS gene, especially in men
Thermal Conductivity near H_c2 for spin-triplet superconducting States with line nodes in Sr_2RuO_4
We calculate the thermal conductivity kappa in magnetic fields near H_c2 for
spin-triplet superconducting states with line nodes vertical and horizontal
relative to the RuO_2-planes. The method for calculating the Green's functions
takes into account the spatial variation of the order parameter and
superconducting flow for the Abrikosov vortex lattice. For in-plane magnetic
field we obtain variations of the in-plane kappa with two-fold symmetry as a
function of rotation angle where the minima and maxima occur for field
directions parallel and perpendicular to the heat flow. The amplitude of the
variation decreases with increasing impurity scattering and temperature. At
higher temperatures the minima and maxima of the variation are interchanged.
Since the results for vertical and horizontal line nodes are almost the same we
cannot say which of the two pairing models is more compatible with recent
measurements of kappa in Sr_2RuO_4. The observed four-fold modulation of kappa
in YBa_2Cu_3O_(7-\delta) is obtained for d-wave pairing by taking into account
the particular shape of the Fermi surface and the finite temperature effect.
The results for kappa for the f-wave pairing state with horizontal line nodes
disagree in some respects with the measurements on UPt_3.Comment: 8 pages, 6 figures. To be published in Phys. Rev.
Quantum critical point in a periodic Anderson model
We investigate the symmetric Periodic Anderson Model (PAM) on a
three-dimensional cubic lattice with nearest-neighbor hopping and hybridization
matrix elements. Using Gutzwiller's variational method and the Hubbard-III
approximation (which corresponds to the exact solution of an appropriate
Falicov-Kimball model in infinite dimensions) we demonstrate the existence of a
quantum critical point at zero temperature. Below a critical value of the
hybridization (or above a critical interaction ) the system is an {\em
insulator} in Gutzwiller's and a {\em semi-metal} in Hubbard's approach,
whereas above (below ) it behaves like a metal in both
approximations. These predictions are compared with the density of states of
the - and -bands calculated from Quantum Monte Carlo and NRG
calculations. Our conclusion is that the half-filled symmetric PAM contains a
{\em metal-semimetal transition}, not a metal-insulator transition as has been
suggested previously.Comment: ReVteX, 10 pages, 2 EPS figures. Minor corrections made in the text
and in the figure captions from the first version. More references added.
Accepted for publication in Physical Review
Muon-Spin Rotation Spectra in the Mixed Phase of High-T_c Superconductors : Thermal Fluctuations and Disorder Effects
We study muon-spin rotation (muSR) spectra in the mixed phase of highly
anisotropic layered superconductors, specifically Bi_2+xSr_2-xCaCu_2O_8+delta
(BSCCO), by modeling the fluid and solid phases of pancake vortices using
liquid-state and density functional methods. The role of thermal fluctuations
in causing motional narrowing of muSR lineshapes is quantified in terms of a
first-principles theory of the flux-lattice melting transition. The effects of
random point pinning are investigated using a replica treatment of liquid state
correlations and a replicated density functional theory. Our results indicate
that motional narrowing in the pure system, although substantial, cannot
account for the remarkably small linewidths obtained experimentally at
relatively high fields and low temperatures. We find that satisfactory
agreement with the muSR data for BSCCO in this regime can be obtained through
the ansatz that this ``phase'' is characterized by frozen short-range
positional correlations reflecting the structure of the liquid just above the
melting transition. This proposal is consistent with recent suggestions of a
``pinned liquid'' or ``glassy'' state of pancake vortices in the presence of
pinning disorder. Our results for the high-temperature liquid phase indicate
that measurable linewidths may be obtained in this phase as a consequence of
density inhomogeneities induced by the pinning disorder. The results presented
here comprise a unified, first-principles theoretical treatment of muSR spectra
in highly anisotropic layered superconductors in terms of a controlled set of
approximations.Comment: 50 pages Latex file, including 10 postscript figure
Nonlinear electrodynamics of p-wave superconductors
We consider the Maxwell-London electrodynamics of three dimensional
superconductors in p-wave pairing states with nodal points or lines in the
energy gap. The current-velocity relation is then nonlinear in the applied
field, cubic for point nodes and quadratic for lines. We obtain explicit
angular and depth dependent expressions for measurable quantities such as the
transverse magnetic moment, and associated torque. These dependences are
different for point and line nodes and can be used to distinguish between
different order parameters. We discuss the experimental feasibility of this
method, and bring forth its advantages, as well as limitations that might be
present.Comment: Fourteen pages RevTex plus four postscript figure
The origin of paramagnetic magnetization in field-cooled YBa2Cu3O7 films
Temperature dependences of the magnetic moment have been measured in
YBa_2Cu_3O_{7-\delta} thin films over a wide magnetic field range (5 <= H <=
10^4 Oe). In these films a paramagnetic signal known as the paramagnetic
Meissner effect has been observed. The experimental data in the films, which
have strong pinning and high critical current densities (J_c ~ 2 \times 10^6
A/cm^2 at 77 K), are quantitatively shown to be highly consistent with the
theoretical model proposed by Koshelev and Larkin [Phys. Rev. B 52, 13559
(1995)]. This finding indicates that the origin of the paramagnetic effect is
ultimately associated with nucleation and inhomogeneous spatial redistribution
of magnetic vortices in a sample which is cooled down in a magnetic field. It
is also shown that the distribution of vortices is extremely sensitive to the
interplay of film properties and the real experimental conditions of the
measurements.Comment: RevTex, 8 figure
Melting and Dimensionality of the Vortex Lattice in Underdoped YBa2Cu3O6.60
Muon spin rotation measurements of the magnetic field distribution in the
vortex state of the oxygen deficient high-Tc superconductor YBa{2}Cu{3}O{6.60}
reveal a vortex-lattice melting transition at much lower temperature than that
in the fully oxygenated material. The transition is best described by a model
in which adjacent layers of ``pancake'' vortices decouple in the liquid phase.
Evidence is also found for a pinning-induced crossover from a solid 3D to
quasi-2D vortex lattice, similar to that observed in the highly anisotropic
superconductor Bi{2+x}Sr{2-x}CaCu{2}O{8+y}.Comment: 8 pages, 4 figures, 5 postscript file
Star Models with Dark Energy
We have constructed star models consisting of four parts: (i) a homogeneous
inner core with anisotropic pressure (ii) an infinitesimal thin shell
separating the core and the envelope; (iii) an envelope of inhomogeneous
density and isotropic pressure; (iv) an infinitesimal thin shell matching the
envelope boundary and the exterior Schwarzschild spacetime. We have analyzed
all the energy conditions for the core, envelope and the two thin shells. We
have found that, in order to have static solutions, at least one of the regions
must be constituted by dark energy. The results show that there is no physical
reason to have a superior limit for the mass of these objects but for the ratio
of mass and radius.Comment: 20 pages, 1 figure, references and some comments added, typos
corrected, in press GR
Putting context to numbers : a geotechnical risk trajectory to cost overrun extremism
The study investigates the cause of the unusually high cost overruns experienced
in highway project delivery in the tropical wetland setting of the Niger Delta
region of Nigeria. This is in view of the extensive literature supporting the link
between geology, the lack of geotechnical best practices and cost overruns. An
empirical profiling of cost overrun research further reveals the predominance of
mono-method studies based on survey methods, correlative analysis and archival
data modelling techniques, all of which are underlain by positivism. The study
argues that such positivist philosophies, although methodologically valid, cannot
adequately explain and provide in-depth understanding of the contextual cost
overrun drivers in highway organisations., Using a robust and thoughtfully
designed mix of methods, the paper examines the contribution of geotechnical
risks to cost overruns experienced in highway project, and demonstrates the
relevance of context in cost overrun research. Cost overrun data from
documentary sources for 61 completed highway projects in the Niger Delta are
gathered and analysed, revealing an average value of 216%, with extreme cases,
ranging up to 1925% of budgeted cost. To uncover the intrinsic contextual
drivers, 16 interviews were conducted with participants from the three highway
agencies in the region, responsible for the execution of the sampled highway
projects. Adopting a geotechnical narrative, the data is thematically analysed,
deductively and inductively. The results of the analysis identified that poor
project governance, management and procurement practices, have inhibited the
competent management of geotechnical risk, creating a propensity for extreme
cost overruns on the highway projects. The study submits the phenomenon of
cost overruns in public infrastructure projects is underlain by a complexity of
contextual social constructs, which would have been overlooked in positivists
studies. Cost overrun research therefore, needs to be contextually and
numerically anchored.
Keywords: Context, Cost overruns, Highway projects, Mixed methods, Social
Construct
Evaluation of a proposal for reliable low-cost grid power with 100% wind, water, and solar
A number of analyses, meta-Analyses, and assessments, including those performed by the Intergovernmental Panel on Climate Change, the National Oceanic and Atmospheric Administration, the National Renewable Energy Laboratory, and the International Energy Agency, have concluded that deployment of a diverse portfolio of clean energy technologies makes a transition to a low-carbon-emission energy system both more feasible and less costly than other pathways. In contrast, Jacobson et al. [Jacobson MZ, Delucchi MA, Cameron MA, Frew BA (2015) Proc Natl Acad Sci USA 112(49):15060-15065] argue that it is feasible to provide low-cost solutions to the grid reliability problem with 100% penetration of WWS [wind, water and solar power] across all energy sectors in the continental United States between 2050 and 2055 , with only electricity and hydrogen as energy carriers. In this paper, we evaluate that study and find significant shortcomings in the analysis. In particular, we point out that this work used invalid modeling tools, contained modeling errors, and made implausible and inadequately supported assumptions. Policy makers should treat with caution any visions of a rapid, reliable, and low-cost transition to entire energy systems that relies almost exclusively on wind, solar, and hydroelectric power
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