22 research outputs found
The Peace Engagement of a Peace Culture: Observations on the National Identity Foundations of Norwegian Foreign Policy
No full textThe lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation
No full textNovel Process of Intrathymic Tumor-Immune Tolerance through CCR2-Mediated Recruitment of Sirpα+ Dendritic Cells: A Murine Model
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Wormwood Review Project
No full textMedullary thymic epithelial cells (mTECs) are critical in establishing and maintaining the appropriate microenvironment for negative selection and maturation of immunocompetent T cells with a self-tolerant T cell antigen receptor repertoire. Cues that direct proliferation and maturation of mTECs are provided by members of the tumor necrosis factor (TNF) superfamily expressed on developing thymocytes. Here we demonstrate a negative role of the morphogen TGF-beta in tempering these signals under physiological conditions, limiting both growth and function of the thymic medulla. Eliminating TGF-beta signaling specifically in TECs or by pharmacological means increased the size of the mTEC compartment, enhanced negative selection and functional maturation of medullary thymocytes as well as the production of regulatory T cells, thus reducing the autoreactive potential of peripheral T cells
Prevalence, socio-demographic characteristics, and comorbid health conditions in pre-dialysis chronic kidney disease: results from the Manitoba chronic kidney disease cohort
No full textInternal diversity and change in the UK: The changing forms and levels of coordination in wages and working conditions within the ceramic tableware sector 1945–2008
No full textA regulatory role for TGF-β signaling in the establishment and function of the thymic medulla
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