Bipyrimidine ruthenium(II) arene complexes : structure, reactivity and cytotoxicity

The synthesis and characterization of complexes [(η6-arene)Ru(N,N′)X][PF6], where arene is para-cymene (p-cym), biphenyl (bip), ethyl benzoate (etb), hexamethylbenzene (hmb), indane (ind) or 1,2,3,4-tetrahydronaphthalene (thn), N,N′ is 2,2′-bipyrimidine (bpm) and X is Cl, Br or I, are reported, including the X-ray crystal structures of [(η6-p-cym)Ru(bpm)I][PF6], [(η6-bip)Ru(bpm)Cl][PF6], [(η6-bip)Ru(bpm)I][PF6] and [(η6-etb)Ru(bpm)Cl][PF6]. Complexes in which N,N′ is 1,10-phenanthroline (phen), 1,10-phenanthroline-5,6-dione or 4,7-diphenyl-1,10-phenanthroline (bathophen) were studied for comparison. The RuII arene complexes undergo ligand-exchange reactions in aqueous solution at 310 K; their half-lives for hydrolysis range from 14 to 715 min. Density functional theory calculations on [(η6-p-cym)Ru(bpm)Cl][PF6], [(η6-p-cym)Ru(bpm)Br][PF6], [(η6-p-cym)Ru(bpm)I][PF6], [(η6-bip)Ru(bpm)Cl][PF6], [(η6-bip)Ru(bpm)Br][PF6] and [(η6-bip)Ru(bpm)I][PF6] suggest that aquation occurs via an associative pathway and that the reaction is thermodynamically favourable when the leaving ligand is I > Br ≈ Cl. pK a* values for the aqua adducts of the complexes range from 6.9 to 7.32. A binding preference for 9-ethylguanine (9-EtG) compared with 9-ethyladenine (9-EtA) was observed for [(η6-p-cym)Ru(bpm)Cl][PF6], [(η6-hmb)Ru(bpm)Cl]+, [(η6-ind)Ru(bpm)Cl]+, [(η6-thn)Ru(bpm)Cl]+, [(η6-p-cym)Ru(phen)Cl]+ and [(η6-p-cym)Ru(bathophen)Cl]+ in aqueous solution at 310 K. The X-ray crystal structure of the guanine complex [(η6-p-cym)Ru(bpm)(9-EtG-N7)][PF6]2 shows multiple hydrogen bonding. Density functional theory calculations show that the 9-EtG adducts of all complexes are thermodynamically preferred compared with those of 9-EtA. However, the bmp complexes are inactive towards A2780 human ovarian cancer cells. Calf thymus DNA interactions for [(η6-p-cym)Ru(bpm)Cl][PF6] and [(η6-p-cym)Ru(phen)Cl][PF6] consist of weak coordinative, intercalative and monofunctional coordination. Binding to biomolecules such as glutathione may play a role in deactivating the bpm complexes

Fetal Doppler Simulator Based on Arduino

Heart rate of the fetal is the main indicator of the fetal life in the womb. Monitoring fetal heart rate can't be done, so a tool is needed to monitoring fetal heart rate. Fetal heart rate can be monitored with fetal doppler. To test the accuracy of Fetal Doppler, a calibration is needed with the Fetal Doppler Simulator. This tool will simulate the fetal heart rate with a BPM value that can be adjusted according to the settings on the device. This module using Arduino as the brain system. On the module there is a selection of BPM  from 60 to 240 BPM with an increase of 30 BPM displayed on 2x16 character LCDs. Based on BPM measurement 6 times using Fetal Doppler, the measurement error in a BPM of 60 to BPM 210 is 0%, while at BPM 240 an error is 0.2%. This module has been compared with the standard devices (Fetal Simulator Brand Fluke Biomedical Ps320), the results of the comparison modules with the comparison tool  has the same error value in 240 BPM is 0.2% and in BPM 210 there is a difference in the result of module Fetal Doppler reading of 210 BPM while in the comparison tool is 209 BPM. Of the measurement data and analysis, it can be concluded that the tool can work and the tool has the same accuracy as the standard device

Status of the ILC Main Linac BPM R&D

An introduction and the status of R&D activities for a high-resolution, "cold" beam position monitor (BPM) and the related read-out electronics are discussed. Two different BPM detector concepts, to be attached to the SC quadrupole and located inside the ILC cryomodule, are currently under investigation: A resonant dipole-mode cavity-style BPM pickup, developed at Fermilab, and a re-entrant resonant coaxial waveguide BPM, designed by CEA-Saclay. While the 1.5 GHz dipole-mode cavity BPM is still in the R&D phase, the re-entrant BPM has already passed first beam tests, including its read-out system. Furthermore, the LAPP group is developing radiation tolerant digital read-out systems, which are tested at the CLIC test facility (CTF).Comment: LCWS / ILC08 conference contribution, 6 pages, 6 figure

Green BPM as a business-oriented discipline : a systematic mapping study and research agenda

Green Business Process Management (BPM) focuses on the ecological impact of business processes. This article provides a systematic mapping study of Green BPM literature to evaluate five attributes of the Green BPM research area: (1) scope, (2) disciplines, (3) accountability, (4) researchers and (5) quality control. The results allow developing a research agenda to enhance Green BPM as an approach for environmentally sustainable organizations. We rely on a dichotomy of knowledge production to present research directives relevant for both academics and practitioners in order to help close a rigor-relevance gap. The involvement of both communities is crucial for Green BPM to advance as an applied, business-oriented discipline

A Survey on Evaluation Factors for Business Process Management Technology

Estimating the value of business process management (BPM) technology is a difficult task to accomplish. Computerized business processes have a strong impact on an organization, and BPM projects have a long-term cost amortization. To systematically analyze BPM technology from an economic-driven perspective, we are currently developing an evaluation framework in the EcoPOST project. In order to empirically validate the relevance of assumed evaluation factors (e.g., process knowledge, business process redesign, end user fears, and communication) we have conducted an online survey among 70 BPM experts from more than 50 industrial and academic organizations. This paper summarizes the results of this survey. Our results help both researchers and practitioners to better understand the evaluation factors that determine the value of BPM technology

Towards a Security Engineering Process Model for Electronic Business Processes

Business process management (BPM) and accompanying systems aim at enabling enterprises to become adaptive. In spite of the dependency of enterprises on secure business processes, BPM languages and techniques provide only little support for security. Several complementary approaches have been proposed for security in the domain of BPM. Nevertheless, support for a systematic procedure for the development of secure electronic business processes is still missing. In this paper, we pinpoint the need for a security engineering process model in the domain of BPM and identify key requirements for such process model.Comment: Ninth European Dependable Computing Conference (EDCC 2012