Exploring opportunities around climate-smart breeding for future food and nutrition security

There is a 95% chance that warming will exceed 2°C by the end of the century (Raftery et al. 2017). Global crop productivity is projected to fall by 5-10 % per degree of warming (Challinor et al. 2014), with even greater losses likely for some crops in some areas. The challenge of meeting future food demand is increasing, and climate change is already diminishing our ability to adapt through crop breeding (Challinor et al. 2016; Aggarwal et al. 2019). Recent research is suggesting that increases in climate variability are already affecting the number of food-insecure people, and that increasing atmospheric CO2 concentrations may affect the nutrient content of some food staples, with serious implications for food and nutrition security (Smith and Myers 2018). New crop varieties will be needed that can deliver higher yields as well as possessing the ability to withstand heat and greater tolerances for the secondary effects of a warmer world, such as increased pressures from drought, water-logging, pests and diseases, and reduced nutritional quality due to higher levels of CO2. The systems for accelerated delivery of climate-resilient varieties into food producers’ hands need to be massively upgraded (Cramer 2018). Innovative holistic breeding strategies for multiple traits will be needed that embrace the full pipeline from trait discovery to varietal deployment and seed system development

GLAAS 2014 Findings: Special report for Africa

The UN-Water GLAAS Special Report for Africa, an initiative led by WHO in close collaboration with the African Ministers' Council on Water and the African Development Bank, provides data from 39 African countries to take stock on progress made during the MDG period and to set the scene for the upcoming SDGs. The report highlights progress made in governance and increased investments. Challenges remain in monitoring as well as targeting funds to reach vulnerable groups

Taking down ‘the Ivory Tower’: leveraging academia for better health outcomes in Uganda

http://deepblue.lib.umich.edu/bitstream/2027.42/112732/1/12914_2011_Article_147.pd

Antiretroviral Therapy for Prevention of HIV Infection: New Clues From an Animal Model

The authors discuss the implications of a new study in macaques of antiretroviral pre-exposure prophylaxis regimens

Piloting a rapid participatory risk assessment methodology of sanitation systems in Maputo, Mozambique

This paper describes the activities of Class-A, established as a platform for multi-stakeholder partnership and learning alliance in Maputo, Mozambique to develop and pilot a methodology to assess risks associated with sanitation. The Participatory Rapid Sanitation System Risk Assessment (PRSSRA) methodology uses local knowledge to prioritise areas where community members are most at risk and to identify parts of the sanitation chain to which high risk can be attributed. The participatory nature of the methodology also gives communities the opportunity to identify their needs and express their priorities to the municipality. This paper outlines the methodology, the challenges and successes of its application it in two low income neighbourhoods of Maputo, Mozambique and the next step in refining the methodology

The Cassava Genome: Current Progress, Future Directions

The starchy swollen roots of cassava provide an essential food source for nearly a billion people, as well as possibilities for bioenergy, yet improvements to nutritional content and resistance to threatening diseases are currently impeded. A 454-based whole genome shotgun sequence has been assembled, which covers 69% of the predicted genome size and 96% of protein-coding gene space, with genome finishing underway. The predicted 30,666 genes and 3,485 alternate splice forms are supported by 1.4 M expressed sequence tags (ESTs). Maps based on simple sequence repeat (SSR)-, and EST-derived single nucleotide polymorphisms (SNPs) already exist. Thanks to the genome sequence, a high-density linkage map is currently being developed from a cross between two diverse cassava cultivars: one susceptible to cassava brown streak disease; the other resistant. An efficient genotyping-by-sequencing (GBS) approach is being developed to catalog SNPs both within the mapping population and among diverse African farmer-preferred varieties of cassava. These resources will accelerate marker-assisted breeding programs, allowing improvements in disease-resistance and nutrition, and will help us understand the genetic basis for disease resistance

EU-funded malaria research under the 6th and 7th Framework Programmes for research and technological development

While malaria research has traditionally been strong in Europe, targeted and sustained support for cooperative malaria research at EU level, namely through the EU's 6th and 7th Framework Programmes for research and technological development, FP6 (2002-2006) and FP7 (2007-2013), has boosted both impact and visibility of European malaria research. Most of the European malaria research community is now organized under a number of comprehensive and complementary research networks and projects, assembled around four key areas: (1) fundamental research on the malaria parasite and the disease, (2) development of new malaria drugs, (3) research and development of a malaria vaccine, and (4) research to control the malaria-transmitting mosquito vector. Considerable efforts were undertaken to ensure adequate participation of research groups from disease-endemic countries, in particular from Africa, with the long-term aim to strengthen cooperative links and research capacities in these countries. The concept of organizing European research through major strategic projects to form a "European Research Area" (ERA) was originally developed in the preparation of FP6, and ERA formation has now turned into a major EU policy objective explicitly inscribed into the Lisbon Treaty. EU-funded malaria research may serve as a showcase to demonstrate how ERA formation can successfully be implemented in a given area of science when several surrounding parameters converge to support implementation of this strategic concept: timely coincidence of political stimuli, responsive programming, a clearly defined - and well confined - area of research, and the readiness of the targeted research community who is well familiar with transnational cooperation at EU level. Major EU-funded malaria projects have evolved into thematic and organizational platforms that can collaborate with other global players. Europe may thus contribute more, and better, to addressing the global research agenda for malaria