70 research outputs found
Predicting olfactory receptor neuron responses from odorant structure
Background Olfactory receptors work at the interface between the chemical world of volatile molecules and the perception of scent in the brain. Their main purpose is to translate chemical space into information that can be processed by neural circuits. Assuming that these receptors have evolved to cope with this task, the analysis of their coding strategy promises to yield valuable insight in how to encode chemical information in an efficient way. Results We mimicked olfactory coding by modeling responses of primary olfactory neurons to small molecules using a large set of physicochemical molecular descriptors and artificial neural networks. We then tested these models by recording in vivo receptor neuron responses to a new set of odorants and successfully predicted the responses of five out of seven receptor neurons. Correlation coefficients ranged from 0.66 to 0.85, demonstrating the applicability of our approach for the analysis of olfactory receptor activation data. The molecular descriptors that are best-suited for response prediction vary for different receptor neurons, implying that each receptor neuron detects a different aspect of chemical space. Finally, we demonstrate that receptor responses themselves can be used as descriptors in a predictive model of neuron activation. Conclusions The chemical meaning of molecular descriptors helps understand structure-response relationships for olfactory receptors and their 'receptive fields'. Moreover, it is possible to predict receptor neuron activation from chemical structure using machine-learning techniques, although this is still complicated by a lack of training data
Edging toward âreasonablyâ good corporate governance
Over four decades, research and policy have created layers of understandings in the quest for âgoodâ corporate governance. The corporate excesses of the 1970s sparked a search for market mechanisms and disclosure to empower shareholders. The UK-focused problems of the 1990s prompted board-centric, structural approaches, while the fall of Enron and many other companies in the early 2000s heightened emphasis on director independence and professionalism. With the financial crisis of 2007-09, however, came a turn in some policy approaches and in academic literature seeking a different way forward. This paper explores those four phases and the discourse each develops and then links each to assumptions about accountability and cognition. After the financial crisis came pointers n policy and practice away from narrow, rationalist prescriptions and toward what the philosopher Stephen Toulmin calls âreasonablenessâ. Acknowledging that heightens awareness of complexity and interdependence in corporate governance practice. The paper then articulates a research agenda concerning what âreasonableâ corporate governance might entail
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Foreground modelling via Gaussian process regression: An application to HERA data
The key challenge in the observation of the redshifted 21-cm signal from
cosmic reionization is its separation from the much brighter foreground
emission. Such separation relies on the different spectral properties of the
two components, although, in real life, the foreground intrinsic spectrum is
often corrupted by the instrumental response, inducing systematic effects that
can further jeopardize the measurement of the 21-cm signal. In this paper, we
use Gaussian Process Regression to model both foreground emission and
instrumental systematics in hours of data from the Hydrogen Epoch of
Reionization Array. We find that a simple co-variance model with three
components matches the data well, giving a residual power spectrum with white
noise properties. These consist of an "intrinsic" and instrumentally corrupted
component with a coherence-scale of 20 MHz and 2.4 MHz respectively (dominating
the line of sight power spectrum over scales h
cMpc) and a baseline dependent periodic signal with a period of
MHz (dominating over h cMpc) which should
be distinguishable from the 21-cm EoR signal whose typical coherence-scales is
MHz
Recommended from our members
Foreground modelling via Gaussian process regression: An application to HERA data
The key challenge in the observation of the redshifted 21-cm signal from
cosmic reionization is its separation from the much brighter foreground
emission. Such separation relies on the different spectral properties of the
two components, although, in real life, the foreground intrinsic spectrum is
often corrupted by the instrumental response, inducing systematic effects that
can further jeopardize the measurement of the 21-cm signal. In this paper, we
use Gaussian Process Regression to model both foreground emission and
instrumental systematics in hours of data from the Hydrogen Epoch of
Reionization Array. We find that a simple co-variance model with three
components matches the data well, giving a residual power spectrum with white
noise properties. These consist of an "intrinsic" and instrumentally corrupted
component with a coherence-scale of 20 MHz and 2.4 MHz respectively (dominating
the line of sight power spectrum over scales h
cMpc) and a baseline dependent periodic signal with a period of
MHz (dominating over h cMpc) which should
be distinguishable from the 21-cm EoR signal whose typical coherence-scales is
MHz
Tephrochronology
Tephrochronology is the use of primary, characterized tephras or cryptotephras as chronostratigraphic marker beds to connect and synchronize geological, paleoenvironmental, or archaeological sequences or events, or soils/paleosols, and, uniquely, to transfer relative or numerical ages or dates to them using stratigraphic and age information together with mineralogical and geochemical compositional data, especially from individual glass-shard analyses, obtained for the tephra/cryptotephra deposits. To function as an age-equivalent correlation and chronostratigraphic dating tool, tephrochronology may be undertaken in three steps: (i) mapping and describing tephras and determining their stratigraphic relationships, (ii) characterizing tephras or cryptotephras in the laboratory, and (iii) dating them using a wide range of geochronological methods. Tephrochronology is also an important tool in volcanology, informing studies on volcanic petrology, volcano eruption histories and hazards, and volcano-climate forcing. Although limitations and challenges remain, multidisciplinary applications of tephrochronology continue to grow markedly
Entwicklung eines Verfahrens zur on-line Wirksamkeitspruefung von Antifoulingmitteln und Bioziden in Biofilmen Abschlussbericht
Available from TIB Hannover: F01B250 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDeutsche Bundesstiftung Umwelt, Osnabrueck (Germany)DEGerman
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