463 research outputs found
On the pion-nucleon coupling constant
In view of persisting misunderstanding about the determination of the
pion-nucleon coupling constants in the Nijmegen multienergy partial-wave
analyses of pp, np, and pbar-p scattering data, we present additional
information which may clarify several points of discussion. We comment on
several recent papers addressing the issue of the pion-nucleon coupling
constant and criticizing the Nijmegen analyses.Comment: 19 pages, Nijmegen preprint THEF-NYM-92-0
DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites
The DISC1 protein is implicated in major mental illnesses including schizophrenia, depression, bipolar disorder, and autism. Aberrant mitochondrial dynamics are also associated with major mental illness. DISC1 plays a role in mitochondrial transport in neuronal axons, but its effects in dendrites have yet to be studied. Further, the mechanisms of this regulation and its role in neuronal development and brain function are poorly understood. Here we have demonstrated that DISC1 couples to the mitochondrial transport and fusion machinery via interaction with the outer mitochondrial membrane GTPase proteins Miro1 and Miro2, the TRAK1 and TRAK2 mitochondrial trafficking adaptors, and the mitochondrial fusion proteins (mitofusins). Using live cell imaging, we show that disruption of the DISC1-Miro-TRAK complex inhibits mitochondrial transport in neurons. We also show that the fusion protein generated from the originally described DISC1 translocation (DISC1-Boymaw) localizes to the mitochondria, where it similarly disrupts mitochondrial dynamics. We also show by super resolution microscopy that DISC1 is localized to endoplasmic reticulum contact sites and that the DISC1-Boymaw fusion protein decreases the endoplasmic reticulum-mitochondria contact area. Moreover, disruption of mitochondrial dynamics by targeting the DISC1-Miro-TRAK complex or upon expression of the DISC1-Boymaw fusion protein impairs the correct development of neuronal dendrites. Thus, DISC1 acts as an important regulator of mitochondrial dynamics in both axons and dendrites to mediate the transport, fusion, and cross-talk of these organelles, and pathological DISC1 isoforms disrupt this critical function leading to abnormal neuronal development
Combined Description of Scattering and Annihilation With A Hadronic Model
A model for the nucleon-antinucleon interaction is presented which is based
on meson-baryon dynamics. The elastic part is the -parity transform of the
Bonn potential. Annihilation into two mesons is described in terms of
microscopic baryon-exchange processes including all possible combinations of
. The remaining
annihilation part is taken into account by a phenomenological energy- and state
independent optical potential of Gaussian form. The model enables a
simultaneous description of nucleon-antinucleon scattering and annihilation
phenomena with fair quality.Comment: revised version, REVTEX, 9 pages, 10 figures available from this URL
ftp://ikp113.ikp.kfa-juelich.de/pub/kph140/nucl-th.9411014.u
Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response
Clearance of mitochondria following damage is critical for neuronal homeostasis. Here, we investigate the role of Miro proteins in mitochondrial turnover by the PINK1/Parkin mitochondrial quality control system in vitro and in vivo. We find that upon mitochondrial damage, Miro is promiscuously ubiquitinated on multiple lysine residues. Genetic deletion of Miro or block of Miro1 ubiquitination and subsequent degradation lead to delayed translocation of the E3 ubiquitin ligase Parkin onto damaged mitochondria and reduced mitochondrial clearance in both fibroblasts and cultured neurons. Disrupted mitophagy in vivo, upon post-natal knockout of Miro1 in hippocampus and cortex, leads to a dramatic increase in mitofusin levels, the appearance of enlarged and hyperfused mitochondria and hyperactivation of the integrated stress response (ISR). Altogether, our results provide new insights into the central role of Miro1 in the regulation of mitochondrial homeostasis and further implicate Miro1 dysfunction in the pathogenesis of human neurodegenerative disease
Backward pion-nucleon scattering
A global analysis of the world data on differential cross sections and
polarization asymmetries of backward pion-nucleon scattering for invariant
collision energies above 3 GeV is performed in a Regge model. Including the
, , and trajectories, we
reproduce both angular distributions and polarization data for small values of
the Mandelstam variable , in contrast to previous analyses. The model
amplitude is used to obtain evidence for baryon resonances with mass below 3
GeV. Our analysis suggests a resonance with a mass of 2.83 GeV as
member of the trajectory from the corresponding Chew-Frautschi
plot.Comment: 12 pages, 16 figure
The high voltage system for the novel MPGD-based photon detectors of COMPASS RICH-1
The architecture of the novel MPGD-based photon detectors of COMPASS RICH-1
consists in a large-size hybrid MPGD multilayer layout combining two layers of
Thick-GEMs and a bulk resistive MICROMEGAS. Concerning biasing voltage, the
Thick-GEMs are segmented in order to reduce the energy released in case of
occasional discharges, while the MICROMEGAS anode is segmented in pads
individually biased at positive voltage, while the micromesh is grounded. In
total, there are ten different electrode types and more than 20000 electrodes
supplied by more than 100 HV channels. Commercial power supply units are used.
The original elements of the power supply system are the architecture of the
voltage distribution net, the compensation, by voltage adjustment, of the
effects of pressure and temperature variation affecting the detector gain and a
sophisticated control software, which allows to protect the detectors against
errors by the operator, to monitor and log voltages and current at 1 Hz rate
and to automatically react to detector misbehaviors. The HV system and its
performance are described in detail as well as the electrical stability of the
detector during the operation at COMPASS.Comment: 5th international conference on Micro-Pattern Gas Detectors
(MPGD2017),presentation by Silvia Dalla Torr
Fast Photon Detection for Particle Identification with COMPASS RICH-1
Particle identification at high rates is an important challenge for many
current and future high-energy physics experiments. The upgrade of the COMPASS
RICH-1 detector requires a new technique for Cherenkov photon detection at
count rates of several per channel in the central detector region, and a
read-out system allowing for trigger rates of up to 100 kHz. To cope with these
requirements, the photon detectors in the central region have been replaced
with the detection system described in this paper. In the peripheral regions,
the existing multi-wire proportional chambers with CsI photocathode are now
read out via a new system employing APV pre-amplifiers and flash ADC chips. The
new detection system consists of multi-anode photomultiplier tubes (MAPMT) and
fast read-out electronics based on the MAD4 discriminator and the F1-TDC chip.
The RICH-1 is in operation in its upgraded version for the 2006 CERN SPS run.
We present the photon detection design, constructive aspects and the first
Cherenkov light in the detector.Comment: Proceedings of the Imaging 2006 conference, Stockholm, Sweden, 27-30
June 2006, 5 pages, 6 figures, to appear in NIM A; corrected typo in caption
of Fig.
Fast photon detection for the COMPASS RICH detector
The COMPASS experiment at the SPS accelerator at CERN uses a large scale Ring
Imaging CHerenkov detector (RICH) to identify pions, kaons and protons in a
wide momentum range. For the data taking in 2006, the COMPASS RICH has been
upgraded in the central photon detection area (25% of the surface) with a new
technology to detect Cherenkov photons at very high count rates of several 10^6
per second and channel and a new dead-time free read-out system, which allows
trigger rates up to 100 kHz. The Cherenkov photons are detected by an array of
576 visible and ultra-violet sensitive multi-anode photomultipliers with 16
channels each. The upgraded detector showed an excellent performance during the
2006 data taking.Comment: Proceeding of the IPRD06 conference (Siena, Okt. 06
The Fast Read-out System for the MAPMTs of COMPASS RICH-1
A fast readout system for the upgrade of the COMPASS RICH detector has been
developed and successfully used for data taking in 2006 and 2007. The new
readout system for the multi-anode PMTs in the central part of the photon
detector of the RICH is based on the high-sensitivity MAD4
preamplifier-discriminator and the dead-time free F1-TDC chip characterized by
high-resolution. The readout electronics has been designed taking into account
the high photon flux in the central part of the detector and the requirement to
run at high trigger rates of up to 100 kHz with negligible dead-time. The
system is designed as a very compact setup and is mounted directly behind the
multi-anode photomultipliers. The data are digitized on the frontend boards and
transferred via optical links to the readout system. The read-out electronics
system is described in detail together with its measured performances.Comment: Proceeding of RICH2007 Conference, Trieste, Oct. 2007. v2: minor
change
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