739 research outputs found
Serial lactate and admission SOFA scores in trauma: an analysis of predictive value in 724 patients with and without traumatic brain injury
Objective: Arterial lactate, base excess (BE), lactate clearance, and Sequential Organ Failure Assessment (SOFA) score have been shown to correlate with outcome in severely injured patients. The goal of the present study was to separately assess their predictive value in patients suffering from traumatic brain injury (TBI) as opposed to patients suffering from injuries not related to the brain. Materials and methods: A total of 724 adult trauma patients with an Injury Severity Score (ISS)≥16 were grouped into patients without TBI (non-TBI), patients with isolated TBI (isolated TBI), and patients with a combination of TBI and non-TBI injuries (combined injuries). The predictive value of the above parameters was then analyzed using both uni- and multivariate analyses. Results: The mean age of the patients was 39years (77% males), with a mean ISS of 32 (range 16-75). Mortality ranged from 14% (non-TBI) to 24% (combined injuries). Admission and serial lactate/BE values were higher in non-survivors of all groups (all p<0.01), but not in patients with isolated TBI. Admission SOFA scores were highest in non-survivors of all groups (p=0.023); subsequently septic patients also showed elevated SOFA scores (p<0.01), except those with isolated TBI. In this group, SOFA score was the only parameter which showed significant differences between survivors and non-survivors. Receiver operating characteristic (ROC) analysis revealed lactate to be the best overall predictor for increased mortality and further septic complications, irrespective of the leading injury. Conclusion: Lactate showed the best performance in predicting sepsis or death in all trauma patients except those with isolated TBI, and the differences were greatest in patients with substantial bleeding. Following isolated TBI, SOFA score was the only parameter which could differentiate survivors from non-survivors on admission, although the SOFA score, too, was not an independent predictor of death following multivariate analysi
Defect configurations and dynamical behavior in a Gay-Berne nematic emulsion
To model a nematic emulsion consisting of a surfactant-coated water droplet
dispersed in a nematic host, we performed a molecular dynamics simulation of a
droplet immersed in a system of 2048 Gay-Berne ellipsoids in a nematic phase.
Strong radial anchoring at the surface of the droplet induced a Saturn ring
defect configuration, consistent with theoretical predictions for very small
droplets. A surface ring configuration was observed for lower radial anchoring
strengths, and a pair of point defects was found near the poles of the droplet
for tangential anchoring. We also simulated the falling ball experiment and
measured the drag force anisotropy, in the presence of strong radial anchoring
as well as zero anchoring strength.Comment: 17 pages, 15 figure
Topological susceptibility with the asqtad action
Chiral perturbation theory predicts that in quantum chromodynamics (QCD),
light dynamical quarks suppress the gauge-field topological susceptibility of
the vacuum. The degree of suppression depends on quark multiplicity and masses.
It provides a strong consistency test for fermion formulations in lattice QCD.
Such tests are especially important for staggered fermion formulations that
lack a full chiral symmetry and use the "fourth-root" procedure to achieve the
desired number of sea quarks. Over the past few years we have measured the
topological susceptibility on a large database of 18 gauge field ensembles,
generated in the presence of 2+1 flavors of dynamical asqtad quarks with up and
down quark masses ranging from 0.05 to 1 in units of the strange quark mass and
lattice spacings ranging from 0.045 fm to 0.12 fm. Our study also includes
three quenched ensembles with lattice spacings ranging from 0.06 to 0.12 fm. We
construct the topological susceptibility from the integrated point-to-point
correlator of the discretized topological charge density F-Fdual. To reduce its
variance, we model the asymptotic tail of the correlator. The continuum
extrapolation of our results for the topological susceptibility agrees nicely
at small quark mass with the predictions of lowest-order SU(3) chiral
perturbation theory, thus lending support to the validity of the fourth-root
procedure.Comment: 28 pp, 6 figs. Version 2 corrects some discussion, some numbers, and
some figures and adds some reference
A LED-Based IR/RGB End-to-End Latency Measurement Device
Achieving a minimal latency within augmented reality (AR) systems is one of the most important factors to achieve a convincing visual impression. It is even more crucial for non-video augmentations such as dynamic projection mappings because in that case the superimposed imagery has to exactly match the dynamic real surface, which obviously cannot be directly influenced or delayed in its movement. In those cases, the inevitable latency is usually compensated for using prediction and extrapolation operations, which require accurate information about the occurring overall latency to exactly predict to the right time frame for the augmentation. Different strategies have been applied to accurately compute this latency. Since some of these AR systems operate within different spectral bands for input and output, it is not possible to apply latency measurement methods encoding time stamps directly into the presented output images as these might not be sensed by used input device.We present a generic latency measurement device which can be used to accurately measure the overall end-to-end latency of camera-based AR systems with an accuracy below one millisecond. It comprises a LED-based time stamp generator displaying the time as a gray code on spatially and spectrally multiple locations. It is controlled by a micro-controller and sensed by an external camera device observing the output display as well as the LED device at the same time
Phase-ordering dynamics of the Gay-Berne nematic liquid crystal
Phase-ordering dynamics in nematic liquid crystals has been the subject of
much active investigation in recent years in theory, experiments and
simulations. With a rapid quench from the isotropic to nematic phase a large
number of topological defects are formed and dominate the subsequent
equilibration process. We present here the results of a molecular dynamics
simulation of the Gay-Berne model of liquid crystals after such a quench in a
system with 65536 molecules. Twist disclination lines as well as type-1 lines
and monopoles were observed. Evidence of dynamical scaling was found in the
behavior of the spatial correlation function and the density of disclination
lines. However, the behavior of the structure factor provides a more sensitive
measure of scaling, and we observed a crossover from a defect dominated regime
at small values of the wavevector to a thermal fluctuation dominated regime at
large wavevector.Comment: 18 pages, 16 figures, animations available at
http://www.physics.brown.edu/Users/faculty/pelcovits/lc/coarsening.htm
A sex-specific switch between visual and olfactory inputs underlies adaptive sex differences in behavior
While males and females largely share the same genome and nervous system, they
differ profoundly in reproductive investments and require distinct behavioral,
morphological and physiological adaptations. How can the nervous system, while
bound by both developmental and biophysical constraints, produce these sexdifferences in behavior? Here we uncover a novel dimorphism in Drosophila
melanogaster that allows deployment of completely different behavioral repertoires in
males and females with minimum changes to circuit architecture. Sexual differentiation
of only a small number of higher-order neurons in the brain leads to a change in
connectivity related to the primary reproductive needs of both sexes - courtship pursuit
in males and communal oviposition in females. This study explains how an apparently
similar brain generates distinct behavioral repertoires in the two sexes and presents a
fundamental principle of neural circuit organization that may be extended to other
species
Theory of Banana Liquid Crystal Phases and Phase Transitions
We study phases and phase transitions that can take place in the newly
discovered banana (bow-shaped or bent-core) liquid crystal molecules. We show
that to completely characterize phases exhibited by such bent-core molecules a
third-rank tensor order parameter is necessary in addition to the
vector and the nematic (second-rank) tensor order parameters. We present an
exhaustive list of possible liquid phases, characterizing them by their
space-symmetry group and order parameters, and catalog the universality classes
of the corresponding phase transitions that we expect to take place in such
bent-core molecular liquid crystals. In addition to the conventional
liquid-crystal phases such as the nematic phase, we predict the existence of
novel liquid phases, including the spontaneously chiral nematic
and chiral polar phases, the orientationally-ordered but
optically isotropic tetrahedratic phase, and a novel nematic phase
with symmetry that is neither uniaxial nor biaxial. Interestingly, the
Isotropic-Tetrahedratic transition is {\em continuous} in mean-field theory,
but is likely driven first-order by thermal fluctuations. We conclude with a
discussion of smectic analogs of these phases and their experimental
signatures.Comment: 28 pgs. RevTex, 32 eps figures, submitted to Phys. Rev.
Mechanosensory interactions drive collective behaviour in Drosophila.
Collective behaviour enhances environmental sensing and decision-making in groups of animals. Experimental and theoretical investigations of schooling fish, flocking birds and human crowds have demonstrated that simple interactions between individuals can explain emergent group dynamics. These findings indicate the existence of neural circuits that support distributed behaviours, but the molecular and cellular identities of relevant sensory pathways are unknown. Here we show that Drosophila melanogaster exhibits collective responses to an aversive odour: individual flies weakly avoid the stimulus, but groups show enhanced escape reactions. Using high-resolution behavioural tracking, computational simulations, genetic perturbations, neural silencing and optogenetic activation we demonstrate that this collective odour avoidance arises from cascades of appendage touch interactions between pairs of flies. Inter-fly touch sensing and collective behaviour require the activity of distal leg mechanosensory sensilla neurons and the mechanosensory channel NOMPC. Remarkably, through these inter-fly encounters, wild-type flies can elicit avoidance behaviour in mutant animals that cannot sense the odour--a basic form of communication. Our data highlight the unexpected importance of social context in the sensory responses of a solitary species and open the door to a neural-circuit-level understanding of collective behaviour in animal groups
Simulating Particle Dispersions in Nematic Liquid-Crystal Solvents
A new method is presented for mesoscopic simulations of particle dispersions
in nematic liquid crystal solvents. It allows efficient first-principle
simulations of the dispersions involving many particles with many-body
interactions mediated by the solvents. A simple demonstration is shown for the
aggregation process of a two dimentional dispersion.Comment: 5 pages, 5 figure
A Smooth Interface Method for Simulating Liquid Crystal Colloid Dispersions
A new method is presented for mesoscopic simulations of particle dispersions
in liquid crystal solvents. It allows efficient first-principle simulations of
the dispersions involving many particles with many-body interactions mediated
by the solvents. Demonstrations have been performed for the aggregation of
colloid dispersions in two-dimensional nematic and smectic-C* solvents
neglecting hydrodynamic effects, which will be taken into account in the near
future.Comment: 13 pages, 4 figure
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