8 research outputs found
An assessment of carbon stock for various land use system in Aravally mountains, Western India
Carbon stock, Forest, Plantation, Agriculture, Carbon mitigation, Carbon sequestration,
Age-related myelin degradation burdens the clearance function of microglia during aging
Myelin is synthesized as a multilamellar membrane, but the mechanisms of membrane turnover are unknown. We found that myelin pieces were gradually released from aging myelin sheaths and were subsequently cleared by microglia. Myelin fragmentation increased with age and led to the formation of insoluble, lipofuscin-like lysosomal inclusions in microglia. Thus, age-related myelin fragmentation is substantial, leading to lysosomal storage and contributing to microglial senescence and immune dysfunction in aging
Pharmacological investigations on possible role of Src kinases in neuroprotective mechanism of ischemic postconditioning in mice
Intrathecal delivery of farnesyl thiosalicylic acid and GW 5074 attenuates hyperalgesia and allodynia in chronic constriction injury-induced neuropathic pain in rats
Behavioural characterisation of chronic unpredictable stress based on ethologically relevant paradigms in rats
The chronic unpredictable stress (CUS) paradigm is extensively used in preclinical research. However,
CUS exhibits translational inconsistencies, some of them resulting from the use of adult rodents,
despite the evidence that vulnerability for many psychiatric disorders accumulates during early life.
Here, we assessed the validity of the CUS model by including ethologically-relevant paradigms in
juvenile rats. Thus, socially-isolated (SI) rats were submitted to CUS and compared with SI (experiment
1) and group-housed controls (experiment 1 and 2). We found that lower body-weight gain and
hyperlocomotion, instead of sucrose consumption and preference, were the best parameters to monitor
the progression of CUS, which also afected gene expression and neurotransmitter contents associated
with that cUS-related phenotype. the behavioural characterisation after cUS placed locomotion and
exploratory activity as the best stress predictors. By employing the exploratory factor analysis, we
reduced each behavioural paradigm to few latent variables which clustered into two general domains
that strongly predicted the CUS condition: (1) hyper-responsivity to novelty and mild threats, and (2)
anxiety/depressive-like response. Altogether, the analyses of observable and latent variables indicate
that early-life stress impairs the arousal-inhibition system leading to augmented and persistent
responses towards novel, rewarding, and mildly-threatening stimuli, accompanied by lower bodyweight gain.Universidad de Costa Rica/[742-B4-240]/UCR/Costa RicaUniversidad de Costa Rica/[742-B3-220]/UCR/Costa RicaUCR::Vicerrector铆a de Investigaci贸n::Unidades de Investigaci贸n::Ciencias de la Salud::Centro de Investigaci贸n en Neurociencias (CIN)UCR::Vicerrector铆a de Investigaci贸n::Unidades de Investigaci贸n::Ciencias Sociales::Instituto de Investigaciones Psicol贸gicas (IIP)UCR::Vicerrector铆a de Investigaci贸n::Unidades de Investigaci贸n::Ciencias de la Salud::Instituto de Investigaciones en Salud (INISA)UCR::Vicerrector铆a de Docencia::Salud::Facultad de Medicin