Personalization in object-based audio for accessibility : a review of advancements for hearing impaired listeners

Hearing loss is widespread and significantly impacts an individual’s ability to engage with broadcast media. Access can be improved through new object-based audio personalization methods. Utilizing the literature on hearing loss and intelligibility this paper develops three dimensions which are evidenced to improve intelligibility: spatial separation, speech to noise ratio and redundancy. These can be personalized, individually or concurrently, using object based audio. A systematic review of all work in object-based audio personalization is then undertaken. These dimensions are utilized to evaluate each project’s approach to personalisation, identifying successful approaches, commercial challenges and the next steps required to ensure continuing improvements to broadcast audio for hard of hearing individuals

Intelligibility vs. comprehension : understanding quality of accessible next-generation audio broadcast

For traditional broadcasting formats, imple-mentation of accessible audio strategies for hard of hear-ing people have used a binary, intelligibility-based ap-proach. In this approach sounds are categorized eitheras speech, contributing to comprehension of content,or non-speech, which can mask the speech and reduceintelligibility. Audio accessibility solutions have there-fore focused on speech enhancement type methods, forwhich several useful standard objective measures of qual-ity exist. Recent developments in next-generation broad-cast audio formats, in particular the roll out of object-based audio, facilitate more in-depth personalisationof the audio experience based on user preferences andneeds. Recent research has demonstrated that manynon-speech sounds do not strictly behave as maskersbut can be critical for comprehension of the narrativefor some viewers. This complex relationship betweenspeech, non-speech audio and the viewer necessitate amore holistic approach to understanding quality of ex-perience of accessible media. This paper reviews pre-vious work and outlines such an approach, discussingaccessibility strategies using next-generation audio for-mats and their implications for developing effective as-sessments of quality

Phenotype and Functional Features of Human Telomerase Reverse Transcriptase Immortalized Human Airway Smooth Muscle Cells from Asthmatic and Non-Asthmatic Donors

© 2017 The Author(s). Asthma is an obstructive respiratory disease characterised by chronic inflammation with airway hyperresponsiveness. In asthmatic airways, there is an increase in airway smooth muscle (ASM) cell bulk, which differs from non-asthmatic ASM in characteristics. This study aimed to assess the usefulness of hTERT immortalisation of human ASM cells as a research tool. Specifically we compared proliferative capacity, inflammatory mediator release and extracellular matrix (ECM) production in hTERT immortalised and parent primary ASM cells from asthmatic and non-asthmatic donors. Our studies revealed no significant differences in proliferation, IL-6 and eotaxin-1 production, or CTGF synthesis between donor-matched parent and hTERT immortalised ASM cell lines. However, deposition of ECM proteins fibronectin and fibulin-1 was significantly lower in immortalised ASM cells compared to corresponding primary cells. Notably, previously reported differences in proliferation and inflammatory mediator release between asthmatic and non-asthmatic ASM cells were retained, but excessive ECM protein deposition in asthmatic ASM cells was lost in hTERT ASM cells. This study shows that hTERT immortalised ASM cells mirror primary ASM cells in proliferation and inflammatory profile characteristics. Moreover, we demonstrate both strengths and weaknesses of this immortalised cell model as a representation of primary ASM cells for future asthma pathophysiological research

The hand of Homo naledi

A nearly complete right hand of an adult hominin was recovered from the Rising Star cave system, South Africa. Based on associated hominin material, the bones of this hand are attributed to Homo naledi. This hand reveals a long, robust thumb and derived wrist morphology that is shared with Neandertals and modern humans, and considered adaptive for intensified manual manipulation. However, the finger bones are longer and more curved than in most australopiths, indicating frequent use of the hand during life for strong grasping during locomotor climbing and suspension. These markedly curved digits in combination with an otherwise human-like wrist and palm indicate a significant degree of climbing, despite the derived nature of many aspects of the hand and other regions of the postcranial skeleton in H. naledi

Cost of managing an episode of relapse in multiple sclerosis in the United States

BACKGROUND: The purpose of this study was to determine the direct medical US cost of managing multiple sclerosis relapses. METHODS: Direct data analysis and cost modeling were employed to derive typical resource use profiles and costs in 2002 US dollars, from the perspective of a third-party payer responsible for comprehensive health-care. The location and scope of health care services provided over a 90-day period were used to define three levels of relapse management. Hospitalization and resulting subsequent care was defined as high intensity management. A medium level of intervention was defined as either use of the emergency room, an observational unit, or administration of acute treatments, such as intravenous methylprednisolone in an outpatient or home setting. The lowest intensity of care comprised physician office visits and symptom-related medications. Data were obtained from many sources including all payer inpatient, ambulatory and emergency room databases from several states, fee schedules, government reports, and literature. All charges were adjusted using cost-to-charge ratios. RESULTS: Average cost per person for high management level was $12,870, based on analysis of 4,634 hospital cases (mean age 48 years, 73$1,847 and mild episode $243. CONCLUSIONS: Management strategies leading to a reduction in the frequency and severity of a relapse, less reliance on inpatient care, or increased access to steroid infusions in the home, would have a substantial impact on the economic consequences of managing relapses