22 research outputs found
Connectivity within and among a Network of Temperate Marine Reserves
Networks of marine reserves are increasingly being promoted as a means of conserving marine biodiversity. One consideration in designing systems of marine reserves is the maintenance of connectivity to ensure the long-term persistence and resilience of populations. Knowledge of connectivity, however, is frequently lacking during marine reserve design and establishment. We characterise patterns of genetic connectivity of 3 key species of habitat-forming macroalgae across an established network of temperate marine reserves on the east coast of Australia and the implications for adaptive management and marine reserve design. Connectivity varied greatly among species. Connectivity was high for the subtidal macroalgae Ecklonia radiata and Phyllospora comosa and neither species showed any clear patterns of genetic structuring with geographic distance within or among marine parks. In contrast, connectivity was low for the intertidal, Hormosira banksii, and there was a strong pattern of isolation by distance. Coastal topography and latitude influenced small scale patterns of genetic structure. These results suggest that some species are well served by the current system of marine reserves in place along this temperate coast but it may be warranted to revisit protection of intertidal habitats to ensure the long-term persistence of important habitat-forming macroalgae. Adaptively managing marine reserve design to maintain connectivity may ensure the long-term persistence and resilience of marine habitats and the biodiversity they support
Multi-objective optimisation of a rock coast evolution model with cosmogenic Be-10 analysis for the quantification of long-term cliff retreat rates
This paper presents a methodology that uses site-specific topographic and cosmogenic 10Be data to perform multi-objective model optimisation of a coupled coastal evolution and cosmogenic radionuclide production model. Optimal parameter estimation of the coupled model minimises discrepancies between model simulations and measured data to reveal the most likely history of rock coast development. This new capability allows a time series of cliff retreat rates to be quantified for rock coast sites over millennial timescales. Without such methods, long-term cliff retreat cannot be understood well, as historical records only cover the past ∼150 years. This is the first study that has (1) applied a process-based coastal evolution model to quantify long-term cliff retreat rates for real rock coast sites and (2) coupled cosmogenic radionuclide analysis with a process-based model. The Dakota optimisation software toolkit is used as an interface between the coupled coastal evolution and cosmogenic radionuclide production model and optimisation libraries. This framework enables future applications of datasets associated with a range of rock coast settings to be explored. Process-based coastal evolution models simplify erosional processes and, as a result, often have equifinality properties, for example that similar topography develops via different evolutionary trajectories. Our results show that coupling modelled topography with modelled 10Be concentrations can reduce equifinality in model outputs. Furthermore, our results reveal that multi-objective optimisation is essential in limiting model equifinality caused by parameter correlation to constrain best-fit model results for real-world sites. Results from two UK sites indicate that the rates of cliff retreat over millennial timescales are primarily driven by the rates of relative sea level rise. These findings provide strong motivation for further studies that investigate the effect of past and future relative sea level rise on cliff retreat at other rock coast sites globally
Current concepts in the diagnosis and management of extra-articular hip impingement syndromes
Purpose
Extra-articular hip impingement syndromes encompass a group of conditions that have previously been an unrecognised source of pain in the hip and on occasion been associated with intra-articular hip impingement as well. As arthroscopic techniques for the hip continue to evolve, the importance of these conditions has been recognised recently and now form an important part of the differential of an individual presenting with hip pain. The aim of this article, therefore, is to provide the reader with an evidence-based and comprehensive update of these syndromes.
Methods
By reviewing past literature, the anatomy, pathophysiology, clinical features and the management of the five common extra-articular hip impingement syndromes were described.
Results
The common extra-articular impingement syndromes are: 1) Ischiofemoral impingement: quadratus femoris muscle becomes compressed between the lesser trochanter and the ischial tuberosity. 2) Subspine impingement: mechanical conflict occurs between an enlarged or malorientated anterior inferior iliac spine and the distal anterior femoral neck. 3) Iliopsoas impingement: mechanical conflict occurs between the iliopsoas muscle and the labrum, resulting in distinct anterior labral pathology. 4) Deep gluteal syndrome: pain occurs in the buttock due to the entrapment of the sciatic nerve in the deep gluteal space. 5) Pectineofoveal impingement: pain occurs when the medial synovial fold impinges against overlying soft tissue, primarily the zona orbicularis. Knowledge for these syndromes still remains limited for reasons mostly relating to their low prevalence and their co-existence with typical femoro-acetabular impingement.
Conclusions
The knowledge of extra-articular hip impingement syndromes is essential and should form a part of the differential diagnoses alongside intra-articular pathology including femoro-acetabular impingement particularly in the younger patient with a non-arthritic hip
The effect of a telerehabilitation virtual reality intervention on functional upper limb activities in people with multiple sclerosis: a study protocol for the TEAMS pilot randomized controlled trial
fMRI of Cocaine Self-Administration in Macaques Reveals Functional Inhibition of Basal Ganglia
Disparities in cocaine-induced neurochemical and metabolic responses between human beings and rodents motivate the use of non-human primates (NHP) to model consequences of repeated cocaine exposure in human subjects. To characterize the functional response to cocaine infusion in NHP brain, we employed contrast-enhanced fMRI during both non-contingent injection of drug and self-administration of cocaine in the magnet. Cocaine robustly decreased cerebral blood volume (CBV) throughout basal ganglia and motor/pre-motor cortex and produced subtle functional inhibition of prefrontal cortex. No brain regions exhibited significant elevation of CBV in response to cocaine challenge. Theses effects in NHP brain are opposite in sign to the cocaine-induced fMRI response in rats, but consistent with previous measurements in NHP based on glucose metabolism. Because the striatal ratio of D2 to D1 receptors is larger in human beings and NHP than rats, we hypothesize that the inhibitory effects of D2 receptor binding dominate the functional response in primates, whereas excitatory D1 receptor stimulation predominates in the rat. If the NHP accurately models the human response to cocaine, downregulation of D2 receptors in human cocaine-abusing populations can be expected to blunt cocaine-induced functional responses, contributing to the weak and variable fMRI responses reported in human basal ganglia following cocaine infusion