Psychosocial Risk Factors and Psychopathological Outcomes: Preliminary Findings in Italian Pregnant Women

The perinatal period may represent a particularly challenging time for expecting parents. Previous studies have highlighted an association between several perinatal risk conditions (e.g., childhood maltreatment, poor social support, and stress levels) and the development of psychopathological symptoms in pregnant women, especially depression symptoms. The current study examined the effects of psychosocial risk factors (childhood maltreatment, poor social support, and stressful events) on anxiety, depression, perceived stress, irritability/anger, relationship problems, psychosomatic symptoms, specific physiological problems, and addiction/at-risk behaviors. Sixty-one pregnant women (age range = 24–45) participating in a larger study completed questionnaires about childhood maltreatment (CECA Q.), Maternity Social Support Scale (MSSS), questionnaire on stressful events, and the Perinatal Assessment of Maternal Affectivity (PAMA) during their pregnancy. Results from regression analysis indicated that the presence of childhood maltreatment predicted elevated depressive symptoms, elevated irritability and anger, and elevated relationship problems. Further, stressful events in the year prior to pregnancy predicted elevated psychosomatic symptoms during pregnancy. No other significant associations were found. In this study, traumatic childhood events were strongly associated with mental health symptoms during pregnancy. This is an important finding that suggests the importance of screening and targeting psychotherapeutic interventions for vulnerable women during pregnancy

Large spread in the representation of compound long-duration dry and hot spells over Europe in CMIP5

Long-duration, sub-seasonal dry spells in combination with high temperature extremes during summer have led to extreme impacts on society and ecosystems in the past. Such events are expected to become more frequent due to increasing temperatures as a result of anthropogenic climate change. However, there is little information on how long-duration dry and hot spells are represented in global climate models (GCMs). In this study, we evaluate 33 CMIP5 (coupled model intercomparison project 5) GCMs in their representation of long-duration dry spells and temperatures during dry spells. We define a dry spell as a consecutive number of days with a daily precipitation of less than 1 mm. CMIP5 models tend to underestimate the persistence of dry spells in northern Europe, while a large variability exists between model estimates in central and southern Europe, where models have contrasting biases. Throughout Europe, we also find a large spread between models in their representation of temperature extremes during dry spells. In central and southern Europe this spread in temperature extremes between models is related to the representation of dry spells, where models that produce longer dry spells also produce higher temperatures, and vice versa. Our results indicate that this variability in model estimates is due to model differences and not internal variability. At latitudes between 50–60∘ N, the differences in the representation of persistent dry spells are strongly related to the representation of persistent anticyclonic systems, such as atmospheric blocking and subtropical ridges. Furthermore, models simulating a higher frequency of anticyclonic systems than ERA5 also simulate temperatures in dry spells that are between 1.4, and 2.8 K warmer than models with a lower frequency in these areas. Overall, there is a large spread between CMIP5 models in their representation of long-duration dry and hot events that is due to errors in the representation of large-scale anticyclonic systems in certain parts of Europe. This information is important to consider when interpreting the plausibility of future projections from climate models and highlights the potential value that improvements in the representation of anticyclonic systems may have for the simulation of impactful hazards.</p

Transcranial cortico-cortical paired associative stimulation (ccPAS) over ventral premotor-motor pathways enhances action performance and corticomotor excitability in young adults more than in elderly adults

Transcranial magnetic stimulation (TMS) methods such as cortico-cortical paired associative stimulation (ccPAS) can increase the strength of functional connectivity between ventral premotor cortex (PMv) and primary motor cortex (M1) via spike timing-dependent plasticity (STDP), leading to enhanced motor functions in young adults. However, whether this STDP-inducing protocol is effective in the aging brain remains unclear. In two groups of young and elderly healthy adults, we evaluated manual dexterity with the 9-hole peg task before and after ccPAS of the left PMv-M1 circuit. We observed that ccPAS enhanced dexterity in young adults, and this effect was anticipated by a progressive increase in motor-evoked potentials (MEPs) during ccPAS administration. No similar effects were observed in elderly individuals or in a control task. Across age groups, we observed that the magnitude of MEP changes predicted larger behavioral improvements. These findings demonstrate that left PMv-to-M1 ccPAS induces functionally specific improvements in young adults' manual dexterity and an increase in corticomotor excitability, but altered plasticity prevents the effectiveness of ccPAS in the elderly

A pilot-plant for the selective recovery of magnesium and calcium from waste brines

The problem of brines disposal has raised great interest towards new strategies for their valorisation through the recovery of minerals or energy. As an example, the spent brine from ion exchange resins regeneration is often discharged into rivers or lakes, thus impacting on the process sustainability. However, such brines can be effectively reconcentrated, after removal of bivalent cations, and reused for the resins regeneration. This work focuses on developing and testing a pilot plant for selective recovery of magnesium and calcium from spent brines exploiting a novel proprietary crystallization unit. This is part of a larger treatment chain for the complete regeneration of the brine, developed within the EU-funded ZERO BRINE project. The pilot crystallizer was tested with the retentate of the nanofiltration unit processing the spent brine from the industrial water production plant of Evides Industriewater B.V. (Rotterdam, The Netherlands). Magnesium and calcium hydroxide were selectively precipitated by adding alkaline solution in two consecutive steps and controlling reaction pH. Performance was assessed in terms of recovery efficiency and purity of produced crystals, observing in most investigated cases a recovery of about 100% and 97% and a purity above 90% and 96%, for magnesium and calcium hydroxide, respectively

Neurophysiological Markers of Premotor–Motor Network Plasticity Predict Motor Performance in Young and Older Adults

Aging is commonly associated with a decline in motor control and neural plasticity. Tuning cortico–cortical interactions between premotor and motor areas is essential for controlling fine manual movements. However, whether plasticity in premotor–motor circuits predicts hand motor abilities in young and elderly humans remains unclear. Here, we administered transcranial magnetic stimulation (TMS) over the ventral premotor cortex (PMv) and primary motor cortex (M1) using the cortico–cortical paired-associative stimulation (ccPAS) protocol to manipulate the strength of PMv-to-M1 connectivity in 14 young and 14 elderly healthy adults. We assessed changes in motor-evoked potentials (MEPs) during ccPAS as an index of PMv-M1 network plasticity. We tested whether the magnitude of MEP changes might predict interindividual differences in performance in two motor tasks that rely on premotor-motor circuits, i.e., the nine-hole pegboard test and a choice reaction task. Results show lower motor performance and decreased PMv-M1 network plasticity in elderly adults. Critically, the slope of MEP changes during ccPAS accurately predicted performance at the two tasks across age groups, with larger slopes (i.e., MEP increase) predicting better motor performance at baseline in both young and elderly participants. These findings suggest that physiological indices of PMv-M1 plasticity could provide a neurophysiological marker of fine motor control across age-groups

No apparent genetic bottleneck in the demographically declining European eel using molecular genetics and forward-time simulations

No apparent genetic bottleneck in the demographically declining European eel using molecular genetics and forward-time simulations

Dextran-curcumin nanoparticles as a methotrexate delivery vehicle: A step forward in breast cancer combination therapy

With the aim to effectively deliver methotrexate (MTX) to breast cancer cells, we designed a nanocarrier system (DC) derived from the self-assembly of a dextran-curcumin conjugate prepared via enzyme chemistry with immobilized laccase acting as a solid biocatalyst. Nanoparticles consisted of homogeneously dispersed nanospheres with a mean diameter of 290 nm, as characterized by combined transmission electron microscopy and dynamic light scattering investigations. DC was able to control the MTX release overtime (t1/2 value of 310 min), with cell internalization studies proving its presence inside MCF-7 cytoplasm. Finally, improved MTX efficacy was obtained in viability assays, and attributed to the synergy of curcumin moieties and loaded MTX as underlined by a combination index (CI) < 1

Pillole di clavic... ultura

The paper presents the cases of tree children with clavicular swelling and a different final diagnosis that offered the opportunity to discuss the key points for the differential diagnosis of clavicular swelling and to draw a rational diagnostic work-up underlining the decisive role of MRI. Although several causes (in order: Chronic Recurrent Multifocal Osteomyelitis, Ewing sarcoma, Tietze syndrome) of clavicular swelling are proposed, it is essential to highlight that main causes are represented by neoplastic and inflammatory causes. However, even if clinical and anamnestic assessment are suitable to disentangle from diagnostic incertitude, imaging is often useful to obtain a diagnosis, before (or even without) biopsy. It is anyway mandatory to rule out neoplasia in all non-traumatic clavicular swelling

Considering weights in real social networks: A review

Network science offers powerful tools to model complex social systems. Most social network science research focuses on topological networks by simply considering the binary state of the links, i.e., their presence or absence. Nonetheless, complex social systems present heterogeneity in link interactions (link weight), and accounting for this heterogeneity, it is mandatory to design reliable social network models. Here, we revisit the topic of weighted social networks (WSNs). By summarizing the main notions, findings, and applications in the field of WSNs, we outline how WSN methodology may improve the modeling of several real problems in social sciences. We are convinced that WSNs may furnish ideas and insights to open interesting lines of new research in the social sciences