A methodology for estimating dog noise in an animal housing facility

A rectangular reverberation chamber was designed, constructed and calibrated for the experimental measurement of the sound power level (acoustic power) of a dog. Calibration of the chamber consisted of comparing the acoustic power measured for a random noise source in the chamber with that for the identical source in a free field environment. Data from dogs indicate that barking noise can be modeled as a square wave pattern with short duration and peak sound power levels in the 500 Hz octave band. A-weighted sound pressure levels of up to 114.7 dBA were absorbed, indicating a potential concern for both animals and man chronically exposed to such environments

Gas gain and signal length measurements with a triple-GEM at different pressures of Ar-, Kr- and Xe-based gas mixtures

We investigate the gas gain behaviour of a triple-GEM configuration in gas mixtures of argon, krypton and xenon with ten and thirty percent of carbon dioxide at pressures between 1 and 3 bar. Since the signal widths affect the dead time behaviour of the detector we present signal length measurements to evaluate the use of the triple-GEM in time-resolved X-ray imaging.Comment: 19 pages, 21 figures, revised version, accepted for publication in Nucl. Instr. and Meth.

Investigation of the performance of an optimised MicroCAT, a GEM and their combination by simulations and current measurements

A MicroCAT (Micro Compteur A Trous) structure which is used for avalanche charge multiplication in gas filled radiation detectors has been optimised with respect to maximum electron transparency and minimum ion feedback. We report on the charge transfer behaviour and the achievable gas gain of this device. A three-dimensional electron and ion transfer simulation is compared to results derived from electric current measurements. Similarly, we present studies of the charge transfer behaviour of a GEM (Gas Electron Multiplier) by current measurements and simulations. Finally, we investigate the combination of the MicroCAT and the GEM by measurements with respect to the performance at different voltage settings, gas mixtures and gas pressures.Comment: 26 pages, 32 figure

ExHuME: A Monte Carlo Event Generator for Exclusive Diffraction

We have written the Exclusive Hadronic Monte Carlo Event (ExHuME) generator. ExHuME implements the perturbative QCD calculation of Khoze, Martin and Ryskin of the process pp-> p+X+p, where X is a centrally produced colour singlet system.Comment: 11 pages, 3 figure

Bloom-Gilman duality of the nucleon structure function and the elastic peak contribution

The occurrence of the Bloom-Gilman duality in the nucleon structure function is investigated by analyzing the Q**2-behavior of low-order moments, both including and excluding the contribution arising from the nucleon elastic peak. The Natchmann definition of the moments has been adopted in order to cancel out target-mass effects. It is shown that the onset of the Bloom-Gilman duality occurs around Q**2 ~ 2 (GeV/c)**2 if only the inelastic part of the nucleon structure function is considered, whereas the inclusion of the nucleon elastic peak contribution leads to remarkable violations of the Bloom-Gilman duality.Comment: in Proc. of the XVI European Conference on Few-body Problems in Physics, Autrans (France), July 199

Chronic acceleration studies - Physiological responses to artificial alterations in weight Progress report

Influence of chronic acceleration on energy metabolism of chickens and animals, as indicated by maintenance feed requiremen

Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis

Pemphigus is an autoimmune blistering disease of the skin and mucous membranes. It is caused by autoantibodies directed against desmosomes, which are the principal adhesion structures between epidermal keratinocytes. Binding of autoantibodies leads to the destruction of desmosomes resulting in the loss of cell-cell adhesion (acantholysis) and epidermal blisters. The plasminogen activator system has been implicated as a proteolytic effector in pemphigus. We have tested inhibitors of the plasminogen activator system with regard to their potential to prevent pemphigus-induced cutaneous pathology. In a human split skin culture system, IgG preparations of sera from pemphigus vulgaris patients caused histopathologic changes (acantholysis) similar to those observed in the original pemphigus disease. All inhibitors that were tested (active site inhibitors directed against uPA, tPA, and/or plasmin; antibodies neutralizing the enzymatic activity of uPA or tPA; substances interfering with the binding of uPA to its specific cell surface receptor uPAR) failed to prevent pemphigus vulgaris IgG-mediated acantholysis. Plasminogen-mediated acantholysis, however, was effectively antagonized by the synthetic active site serine protease inhibitor WX-UK1 or by p-aminomethylbenzoic acid. Our data argue against applying anti-plasminogen activator/anti-plasmin strategies in the management of pemphigus

Towards a Precise Parton Luminosity Determination at the CERN LHC

A new approach to determine the LHC luminosity is investigated. Instead of employing the proton-proton luminosity measurement, we suggest to measure directly the parton-parton luminosity. It is shown that the electron and muon pseudorapidity distributions, originating from the decay of W+, W- and Z0 bosons produced at 14 TeV pp collisions (LHC), constrain the x distributions of sea and valence quarks and antiquarks in the range from about 3 x 10**-4 to about 10**-1 at a Q**2 of about 10**4 GeV**2. Furthermore, it is demonstrated that, once the quark and antiquark structure functions are constrained from the W+,W- and Z0 production dynamics, other quark-antiquark related scattering processes at the LHC like q-qbar --> W+W- can be predicted accurately. Thus, the lepton pseudorapidity distributions provide the key to a precise parton luminosity monitor at the LHC, with accuracies of about +-1% compared to the so far considered goal of +-5%.Comment: plain tex, 14 pages, 5 figure

On Justification, Idealization, and Discursive Purchase

Conceptions of acceptability-based moral or political justification take it that authoritative acceptability, widely conceived, constitutes, or contributes to, validity, or justification. There is no agreement as to what bar for authoritativeness such justification may employ. The paper engages the issue in relation to (i) the level of idealization that a bar for authoritativeness, ψ, imparts to a standard of acceptability-based justification, S, and (ii) the degree of discursive purchase of the discursive standing that S accords to people when it builds ψ. I argue that (i) and (ii) are interdependent: high idealization values entail low discursive purchase, while high degrees of purchase require low idealization values. I then distinguish between alethic conceptions of justification that prioritize ends that commit to high idealization values, and recognitive conceptions that favor high discursive purchase. On this basis, I argue for a moderately recognitivist constraint on idealization. To render the recognitive discursive minimum available to relevant people at the site of justification, S should set ψ low enough so that it is a genuine option for actual people to reject relevant views in ways that S recognizes as authoritative. (The Appendix applies this to a Forst-type view of reciprocity of reasons to draw out some limitations of this view.) [Draft available from author on request.