Efecto del número de indicadores por factor sobre la identificación y estimación en modelos aditivos de análisis factorial confirmatorio

La matriz multirrasgo-multimétodo (MRMM) es un diseño de investigación de larga tradición en Psicología. Las técnicas de análisis de datos adecuadas para una correcta extracción de conclusiones han estado sujetas a controversia. Parece, no obstante, que diversos modelos de análisis factorial confirmatorio resultan muy adecuados. De entre los diversos modelos, dos de ellos han recibido gran atención, el modelo completo, que apareció primero en la literatura, y el de unicidades correlacionadas, que parece una alternativa razonable a los problemas que aparecen en el primero. Los resultados de ambos modelos en la literatura se refieren a situaciones con un solo indicador por combinación rasgo-método. La presente investigación simula datos de matrices MRMM para múltiples indicadores por combinación rasgo-método y somete a prueba la adecuación de las estimaciones de ambos modelos. Los resultados apuntan a un mejor comportamiento del modelo completo, si bien los sesgos, aunque triviales en cuantía, aumentan conforme aumenta la correlación entre los métodos

Clinical and magnetic resonance imaging characteristics of thoracolumbar intervertenral disk extrusions and protrusions in large breed dogs

It has recently been shown that the fat-derived hormone adiponectin has the ability to decrease hyperglycemia and to reverse insulin resistance. However, bacterially produced full-length adiponectin is functionally inactive. Here, we show that endogenous adiponectin secreted by adipocytes is post-translationally modified into eight different isoforms, as shown by two-dimensional gel electrophoresis. Carbohydrate detection revealed that six of the adiponectin isoforms are glycosylated. The glycosylation sites were mapped to several lysines (residues 68, 71, 80, and 104) located in the collagenous domain of adiponectin, each having the surrounding motif of GXKGE(D). These four lysines were found to be hydroxylated and subsequently glycosylated. The glycosides attached to each of these four hydroxylated lysines are possibly glucosylgalactosyl groups. Functional analysis revealed that full-length adiponectin produced by mammalian cells is much more potent than bacterially generated adiponectin in enhancing the ability of subphysiological concentrations of insulin to inhibit gluconeogenesis in primary rat hepatocytes, whereas this insulin-sensitizing ability was significantly attenuated when the four glycosylated lysines were substituted with arginines. These results indicate that full-length adiponectin produced by mammalian cells is functionally active as an insulin sensitizer and that hydroxylation and glycosylation of the four lysines in the collagenous domain might contribute to this activity.link_to_subscribed_fulltex

Monolithic integration of Giant Magnetoresistance (GMR) devices onto standard processed CMOS dies

Giant Magnetoresistance (GMR) based technology is nowadays the preferred option for low magnetic fields sensing in disciplines such as biotechnology or microelectronics. Their compatibility with standard CMOS processes is currently investigated as a key point for the development of novel applications, requiring compact electronic readout. In this paper, such compatibility has been experimentally studied with two particular non-dedicated CMOS standards: 0.35 μm from AMS (Austria MicroSystems) and 2.5 μm from CNM (Centre Nacional de Microelectrònica, Barcelona) as representative examples. GMR test devices have been designed and fabricated onto processed chips from both technologies. In order to evaluate so obtained devices, an extended characterization has been carried out including DC magnetic measurements and noise analysis. Moreover, a 2D-FEM (Finite Element Method) model, including the dependence of the GMR device resistance with the magnetic field, has been also developed and simulated. Its potential use as electric current sensors at the integrated circuit level has also been demonstrated

Mixed Early and Late-Type Properties in the Bar of NGC 6221: Evidence for Evolution along the Hubble Sequence?

Rotation curves and velocity dispersion profiles are presented for both the stellar and gaseous components along five different position angles (P.A.=5, 50, 95, 125 and 155 degrees) of the nearby barred spiral NGC 6221. The observed kinematics extends out to about 80" from the nucleus. Narrow and broad-band imaging is also presented. The radial profiles of the fluxes ratio [NII]/Halpha reveal the presence of a ring-like structure of ionized gas, with a radius of about 9" and a deprojected circular velocity of about 280 km/s. The analysis of the dynamics of the bar indicates this ring is related to the presence of an inner Lindblad resonance (ILR) at 1.3 kpc. NGC6221 is found to exhibit intermediate properties between those of the early-type barred galaxies: the presence of a gaseous ring at an ILR, the bar edge located between the ILR's and the corotation radius beyond the steep rising portion of the rotation curve, the dust-lane pattern, and those of the late-type galaxies: an almost exponential surface brightness profile, the presence of Halpha regions along all the bar, the spiral-arm pattern. It is consistent with scenarios of bar-induced evolution from later to earlier-type galaxies.Comment: 1 File ds7406.tar.gz which contains: one latex file (ds7406.tex), and 10 encsulated postscript figures (ds7406f**.eps). To be compiled with aa-l latex2e macro style. To be published in A&A Sup. Serie