14 research outputs found
Missed opportunities for tobacco use screening and brief cessation advice in South African primary health care: a cross-sectional study
A simple correlation for prediction of autoignition temperature of various classes of hydrocarbons
Human Lung Cancer Risks from Radon – Part I - Influence from Bystander Effects - A Microdose Analysis
Since the publication of the BEIR VI report in 1999 on health risks from radon, a significant amount of new data has been published showing various mechanisms that may affect the ultimate assessment of radon as a carcinogen, at low domestic and workplace radon levels, in particular the Bystander Effect (BE) and the Adaptive Response radio-protection (AR). We analyzed the microbeam and broadbeam alpha particle data of Miller et al. (1995, 1999), Zhou et al. (2001, 2003, 2004), Nagasawa and Little (1999, 2002), Hei et al. (1999), Sawant et al. (2001a) and found that the shape of the cellular response to alphas is relatively independent of cell species and LET of the alphas. The same alpha particle traversal dose response behavior should be true for human lung tissue exposure to radon progeny alpha particles. In the Bystander Damage Region of the alpha particle response, there is a variation of RBE from about 10 to 35. There is a transition region between the Bystander Damage Region and Direct Damage Region of between one and two microdose alpha particle traversals indicating that perhaps two alpha particle “hits” are necessary to produce the direct damage. Extrapolation of underground miners lung cancer risks to human risks at domestic and workplace levels may not be valid
The impact of data quality and source data verification on epidemiologic inference: a practical application using HIV observational data
Correlation of intraoperative ultrasound tumor volumes and margins with preoperative computerized tomography scans
Hormesis by Low Dose Radiation Effects: Low-Dose Cancer Risk Modeling Must Recognize Up-Regulation of Protection
Study of ion–solvent interactions and activation energy of LiBr in DMSO, H2O and DMSO–H2O mixtures at various temperatures
UV-inducible proteins and UV-induced cross-protection against acid, ethanol, H2O2 or heat treatments in Lactococcus lactis subsp. lactis
Animal models of obesity and diabetes mellitus.
More than one-third of the worldwide population is overweight or obese and therefore at risk of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more potent therapeutics are urgently required. This necessitates the continued use of animal models to discover, validate and optimize novel therapeutics for their safe use in humans. In order to improve the transition from bench to bedside, researchers must not only carefully select the appropriate model but also draw the right conclusions. In this Review, we consolidate the key information on the currently available animal models of obesity and diabetes and highlight the advantages, limitations and important caveats of each of these models