3,5-nonadiyne isolated from the rhizome of Cachrys ferulacea inhibits endogenous nitric oxide release by rat peritoneal macrophages

3,5-Nonadiyne, in vitro, selectively inhibits endogenous nitric oxide release (IC50=6.7 +/- 0.8 mum) by rat peritoneal macrophages at doses that do not inhibit T cell proliferation. 3,5-Nonadiyne was isolated from root essential oil of Cachrys ferulacea (L.) CALESTANI, synonym Prangos ferulacea (L.) LINDLEY, obtained by hydrodistillation and spectrometricaly identified unambiguously

AGN STORM 2. IV. Swift X-Ray and Ultraviolet/Optical Monitoring of Mrk 817

The AGN STORM 2 campaign is a large, multiwavelength reverberation mapping project designed to trace out the structure of Mrk 817 from the inner accretion disk to the broad emission line region and out to the dusty torus. As part of this campaign, Swift performed daily monitoring of Mrk 817 for approximately 15 months, obtaining observations in X-rays and six UV/optical filters. The X-ray monitoring shows that Mrk 817 was in a significantly fainter state than in previous observations, with only a brief flare where it reached prior flux levels. The X-ray spectrum is heavily obscured. The UV/optical light curves show significant variability throughout the campaign and are well correlated with one another, but uncorrelated with the X-rays. Combining the Swift UV/optical light curves with Hubble Space Telescope UV continuum light curves, we measure interband continuum lags, τ(λ), that increase with increasing wavelength roughly following τ(λ) ∝ λ 4/3, the dependence expected for a geometrically thin, optically thick, centrally illuminated disk. Modeling of the light curves reveals a period at the beginning of the campaign where the response of the continuum is suppressed compared to later in the light curve—the light curves are not simple shifted and scaled versions of each other. The interval of suppressed response corresponds to a period of high UV line and X-ray absorption, and reduced emission line variability amplitudes. We suggest that this indicates a significant contribution to the continuum from the broad-line region gas that sees an absorbed ionizing continuum.</p

AGN STORM 2. III. A NICER View of the Variable X-Ray Obscurer in Mrk 817

The AGN STORM 2 Collaboration targeted the Seyfert 1 galaxy Mrk 817 for a year-long multiwavelength, coordinated reverberation mapping campaign including Hubble Space Telescope, Swift, XMM-Newton, NICER, and ground-based observatories. Early observations with NICER and XMM revealed an X-ray state 10 times fainter than historical observations, consistent with the presence of a new dust-free, ionized obscurer. The following analysis of NICER spectra attributes variability in the observed X-ray flux to changes in both the column density of the obscurer by at least one order of magnitude (N H ranges from 2.85 − 0.33 + 0.48 × 10 22 cm − 2 to 25.6 − 3.5 + 3.0 × 10 22 cm − 2 ) and the intrinsic continuum brightness (the unobscured flux ranges from 10−11.8 to 10−10.5 erg s−1 cm−2). While the X-ray flux generally remains in a faint state, there is one large flare during which Mrk 817 returns to its historical mean flux. The obscuring gas is still present at lower column density during the flare, but it also becomes highly ionized, increasing its transparency. Correlation between the column density of the X-ray obscurer and the strength of UV broad absorption lines suggests that the X-ray and UV continua are both affected by the same obscuration, consistent with a clumpy disk wind launched from the inner broad-line region

AGN STORM 2. II. Ultraviolet Observations of Mrk 817 with the Cosmic Origins Spectrograph on the Hubble Space Telescope

We present reverberation mapping measurements for the prominent ultraviolet broad emission lines of the active galactic nucleus Mrk 817 using 165 spectra obtained with the Cosmic Origins Spectrograph on the Hubble Space Telescope. Our ultraviolet observations are accompanied by X-ray, optical, and near-infrared observations as part of the AGN Space Telescope and Optical Reverberation Mapping Program 2 (AGN STORM 2). Using the cross-correlation lag analysis method, we find significant correlated variations in the continuum and emission-line light curves. We measure rest-frame delayed responses between the far-ultraviolet continuum at 1180 Å and Lyα λ1215 Å ( 10.4 − 1.4 + 1.6 days), N v λ1240 Å ( 15.5 − 4.8 + 1.0 days), Si iv + ]O iv λ1397 Å ( 8.2 − 1.4 + 1.4 days), C iv λ1549 Å ( 11.8 − 2.8 + 3.0 days), and He ii λ1640 Å ( 9.0 − 1.9 + 4.5 days) using segments of the emission-line profile that are unaffected by absorption and blending, which results in sampling different velocity ranges for each line. However, we find that the emission-line responses to continuum variations are more complex than a simple smoothed, shifted, and scaled version of the continuum light curve. We also measure velocity-resolved lags for the Lyα and C iv emission lines. The lag profile in the blue wing of Lyα is consistent with virial motion, with longer lags dominating at lower velocities, and shorter lags at higher velocities. The C iv lag profile shows the signature of a thick rotating disk, with the shortest lags in the wings, local peaks at ±1500 km s−1, and a local minimum at the line center. The other emission lines are dominated by broad absorption lines and blending with adjacent emission lines. These require detailed models, and will be presented in future work