Çocukluk çağında mannoz bağlayıcı lektin gen polimorfizminin bruselloza yatkınlıktaki rolü

Bu tezin, veri tabanı üzerinden yayınlanma izni bulunmamaktadır. Yayınlanma izni olmayan tezlerin basılı kopyalarına Üniversite kütüphaneniz aracılığıyla (TÜBESS üzerinden) erişebilirsiniz.[Abstarct Not Available

Ender bulgularla başvuran iki inkomplet kawasaki hastalığı olgusu

Early recognition and prompt treatment of Kawasaki disease are essential to ensure a successful outcome of coronary artery involvement. A specific diagnostic test is not available and the diagnosis is based on the presence of characteristic clinical findings. However, in some patients with lack of sufficient clinical signs to fulfill the diagnostic criteria are called incomplete Kawasaki disease. There may be problems in diagnosing infants presenting with rare symptoms. Here we presented two infants diagnosed with incomplete Kawasaki disease who presented with rare symptoms. The first patient presented with a history of persistent fever for seven days, irritability and strawberry tongue. Subsequently erythema with induration was noticed around the BCG site. The second patient presented with fever, maculopapular rash and transient hemiparesis. The coronary abnormalities were observed by echocardiography in both patients. Incomplete Kawasaki disease was diagnosed, and therapy with acetylsalicylic acid and intravenous gamma globulin was initiated in both patients.Kawasaki hastalığının erken tanısı ve hızlı tedavisi, koroner arter tutuluşu üzerinde olumlu sonuçların elde edilmesi için esastır. Özgül bir tanısal testi yoktur ve tanı karakteristik klinik bulgular ile konulur. Bazı hastalarda klinik tanı kriterlerinden tanı için yeterli sayıda kriter yoktur, bu durum inkomplet Kawasaki hastalığı olarak tanımlanır. Ender bulgular ile başvuran süt çocuklarında tanı güçlükleri olabilir. Burada, inkomplet Kawasaki hastalığı tanısı olan ender görülen bulgularla başvuran iki süt çocuğu sunuldu. İlk hasta yedi gündür devam eden ateş, huzursuzluk ve makülopapüler döküntü yakınmaları ile başvurdu. İzleminde BCG aşısı yerinde endürasyonlu eritem gelişti. İkinci hasta ise ateş, makülopapüler döküntü ve hemiparezi bulguları ile başvurdu. Her iki hastanın ekokardiyografik incelemesinde koroner arter anormallikleri saptandı. Hastalar inkomplet Kawasaki hastalığı tanısı alarak asetil salisilik asit ve intavenöz immünglobülin tedavisi başlandı

Prognostic factors in patients with metastatic urothelial carcinoma who have been treated with atezolizumab

Background: In the current study, we evaluated pretreatment prognostic factors foroverall survival (OS) in patients with metastatic urothelial carcinoma who have progressed after first-line chemotherapy in the Expanded-Access Program ofatezolizumab.Methods: In this study, we present the retrospective analysis of 113 patients withurothelial cancer treated with ATZ after progression on first-line chemotherapy.Eligible patients included metastatic urothelial carcinoma patients treated with at leastone course of ATZ. Univariate analysis was used to identify clinical and laboratoryfactors that significantly impact OS. Variables were retained for multivariate analysis ifthey had a statistical relationship with OS (P˂0.1) and were then included the finalmodel if P˂0.05.Results: In univariate analysis, primary tumour location in the upper tract, increasedabsolute neutrophil count (ANC), increased absolute lymphocyte count, neutrophil-tolymphocyte ratio (NLR)>3, liver metastases, baseline creatinine clearance (GFR) 3 (HR¼ 0.474; 95% CI 0.234-0.962; P ¼0.039) and GFR 3 andGFR <60 ml/min. Taken together, these factors can be used for prognostic parametersin clinical trials that use immunotherapy in patients with bladder cancer who haveprogressed after first-line chemotherapy.European Society for Medical Oncolog