Expanded Perlite-Polyphosphoric Acid (EP-PPA) as a Low-Cost Heterogeneous Solid Acid Catalyst for Green and Metal-Free Synthesis of Nitriles from Aldehydes

Expanded Perlite-Polyphosphoric Acid (EP-PPA) as a solid acid catalyst reported earlier by our group, has been found to be very effective for direct transformation of aldehydes into nitriles. The aforesaid catalyst exhibited excellent catalytic activity in high yielding preparation of a wide range of nitriles under solvent-free conditions. Furthermore, the method consistently has the advantages of environmental acceptability, short reaction times, excellent functional group compatibility and easy experimental and work-up procedures. Importantly, catalyst reusability up to six runs with little loss of catalytic activity made the present procedure better than the most previously reported protocols

Sun-light-driven Suzuki-Miyaura Cross-coupling using a Novel Superparamagnetic Metal-organic Framework Catalyst

A prominent catalytic activity for sun-light driven Suzuki-Miyaura cross-coupling reaction has been shown in the presence of superparamagnetic core-shell metal-organic framework (Fe3O4@Ni-Co-BTC NPs) (with particle size 10–47 nm) and unique bimetallic core-shell nanostructure). Various aryl halides with electron-donating or electron-withdrawing substituents were coupled with different arylboronic acids towards corresponding products at ambient temperature in H2O. The results of photocatalysis demonstrate that Fe3O4@Ni-Co-BTC NPs is a good photocatalyst under sun light irradiation with high efficiency, chemoselectivity and functional group tolerance. This magnetic separable nanostructured catalyst can be reused more than six times with minimal loss of catalytic activity rendering this catalyst long-term stability. The results acquired in the present study can serve as inspiration for the further exploitation of the sun-light-driven cross-coupling reaction under mild conditions. This work is licensed under a Creative Commons Attribution 4.0 International License

Direct and Facile Synthesis of Acyl Isothiocyanates from Carboxylic Acids Using Trichloroisocyanuric Acid/Triphenylphosphine System

A mild, efficient, and practical method for one-step synthesis of alkanoyl and aroyl isothiocyanates from carboxylic acids using a safe and inexpensive mixed reagent, trichloroisocyanuric acid/triphenyl¬phosphine is described at room temperature. Availability of the reagents and easy workup of the reaction make this method attractive for organic chemists

A Novel Approach for the Synthesis of 5-Substituted-1H-tetrazoles

Uma série de 1H-tetrazóis-5-substituídos (RCN 4 H) foi sintetizada pela reação de cicloadição de diferentes aril e alquil nitrilas com azida de sódio em DMSO, usando CuSO 4 •5H 2 O como catalisador. Uma grande variedade de aril nitrilas sofreu cicloadição [3+2], obtendo-se os correspondentes tetrazóis sob condições reacionais brandas. O catalisador utilizado é obtido facilmente e ambientalmente correto. Tempos de reação curtos, bons a excelentes rendimentos, processo seguro e simples tornam este método uma contribuição atrativa e útil à presente síntese orgânica de 1H-tetrazóis-5-substituídos. A series of 5-substituted-1H-tetrazoles (RCN 4 H) have been synthesized by cycloaddition reaction of different aryl and alkyl nitriles with sodium azide in DMSO using CuSO 4 •5H 2 O as catalyst. A wide variety of aryl nitriles underwent [3+2] cycloaddition to afford tetrazoles under mild reaction conditions in good to excellent yields. The catalyst used is readily available and environmentally friendly. Short reaction times, good to excellent yields, safe process and simple workup make this method an attractive and useful contribution to present organic synthesis of 5-substituted-1H-tetrazoles

A mild and simple iodination of phenols with trichloroisocyanuric acid/ I2 /Wet SiO2 system

Molecular iodine in the presence of trichloroisocyanuric acid and wet SiO2 has been utilized efficiently for iodination of phenols under mild reaction conditions

A One-Pot, fast, and efficient amidation of carboxylic acids, α-amino acids and sulfonic acids using pph₃/<i>n</i>-chlorobenzotriazole system

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