28 research outputs found

    Simulation of forest harvesting alternative processes and concept design of an innovative skidding winch focused on productivity improvement

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    In contexts in which mechanized harvesting is limited, such as in the northwestern Black Sea region of Turkey, it is important to improve timber harvesting productivity while preserving operators' safety and reducing environmental damage. This study aims to introduce a methodology in which the harvesting process is simulated with discrete-event simulation (DES) software in order to identify bottlenecks. An alternative process is compared to the original within the DES software, carrying out further steps oriented to the generation of new innovative product concepts. As a case study, the design of an innovative skidding winch is proposed. The development of the product was focused towards customer satisfaction by collecting customer requirements and identifying quality characteristics with a quality function deployment approach. Contradictions identified in the design phase were solved using the TRIZ contradiction toolkit, generating different product concepts. Inventive solutions provided by TRIZ were designed within parametric CAD software. The concepts were compared in a virtual environment, eventually selecting an optimal solution. The results showed that, with the concept adopted, it is possible to achieve a substantial increase in productivity, from 121% to 133%, in terms of kilograms of logs per hour deposited on the landing

    the numerics of physical parametrization in the ecmwf model

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    The numerical aspects of physical parametrization are discussed mainly in the context of the ECMWF Integrated Forecasting System. Two time integration techniques are discussed. With parallel splitting the tendencies of all the parametrized processes are computed independently of each other. With sequential splitting, tendencies of the explicit processes are computed first and are used as input to the subsequent implicit fast process. It is argued that sequential splitting is better than parallel splitting for problems with multiple time scales, because a balance between processes is obtained during the time integration. It is shown that sequential splitting applied to boundary layer diffusion in the ECMWF model leads to much smaller time truncation errors than does parallel splitting. The so called Semi-Lagrangian Averaging of Physical Parametrizations (SLAVEPP), as implemented in the ECMWF model, is explained. The scheme reduces time truncation errors compared to standard first order methods, although a few implementation questions remain. In the scheme fast and slow processes are handled differently and it remains a research topic to find the optimal way of handling convection and clouds. Process specific numerical issues are discussed in the context of the ECMWF parametrization package. Examples are the non-linear stability problems in the vertical diffusion scheme, the stability related mass flux limit in the convection scheme and the fast processes in the cloud microphysics. Vertical resolution in the land surface scheme is inspired by the requirement to represent diurnal to annual time scales. Finally, a new coupling strategy between atmospheric models and land surface schemes is discussed. It allows for fully implicit coupling also for tiled land surface schemes

    The Cooperation between hMena Overexpression and HER2 Signalling in Breast Cancer

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    hMena and the epithelial specific isoform hMena11a are actin cytoskeleton regulatory proteins belonging to the Ena/VASP family. EGF treatment of breast cancer cell lines upregulates hMena/hMena11a expression and phosphorylates hMena11a, suggesting cross-talk between the ErbB receptor family and hMena/hMena11a in breast cancer. The aim of this study was to determine whether the hMena/hMena11a overexpression cooperates with HER-2 signalling, thereby affecting the HER2 mitogenic activity in breast cancer. In a cohort of breast cancer tissue samples a significant correlation among hMena, HER2 overexpression, the proliferation index (high Ki67), and phosphorylated MAPK and AKT was found and among the molecular subtypes the highest frequency of hMena overexpressing tumors was found in the HER2 subtype. From a clinical viewpoint, concomitant overexpression of HER2 and hMena identifies a subgroup of breast cancer patients showing the worst prognosis, indicating that hMena overexpression adds prognostic information to HER2 overexpressing tumors. To identify a functional link between HER2 and hMena, we show here that HER2 transfection in MCF7 cells increased hMena/hMena11a expression and hMena11a phosphorylation. On the other hand, hMena/hMena11a knock-down reduced HER3, AKT and p44/42 MAPK phosphorylation and inhibited the EGF and NRG1-dependent HER2 phosphorylation and cell proliferation. Of functional significance, hMena/hMena11a knock-down reduced the mitogenic activity of EGF and NRG1. Collectively these data provide new insights into the relevance of hMena and hMena11a as downstream effectors of the ErbB receptor family which may represent a novel prognostic indicator in breast cancer progression, helping to stratify patients

    Collaborative Environments, Knowledge Creation and Knowledge Reuse for Railway Industries

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    This paper deals with the development of a Knowledge Based Engineering (KBE) methodology for supporting a manufacturing company, in particular railway manufacturers, in their analyses for reusing existing products in new projects. The proposed methodology is based on the development of a Decision Support System (DSS) and the use of an analysis, called Adopt/Adapt/Innovate (AAI), aimed at identifying products already designed that fully or partly fit what required by new bids. The DSS is built within a PLM software and part of the research concentrated on comparing the PLM suites available in the market searching for the best tool able to act the role of a centralized management dashboard for knowledge reuse. DSS and AAI analysis are the base for future research activities for obtaining a KBE system that automatically models complex railway products starting from the customer requirements, drastically reducing the time to market

    A new interactive railway virtual simulator for testing preventive safety

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    The objective of the work is to describe the design and the realization of a virtual simulator of a metropolitan railway cockpit, aimed at improving the perception of safety by means of tests made by users in Virtual Reality, analysed through statistical methodologies. The user lives the experience of a driver in an immersive and interactive Augmented Reality session, interacting with the train dashboard and all its control and signalling devices. In particular, the user is proposed to test different dashboards, different configurations of the controls and different signalling and safety devices in order to compare different concept and select the optimum in terms of perception of dangerous situation, reaction to an event and cognitive response in different situations of the rail vehicle driving. The simulator consists of a simulacrum integrating different technologies, physically composed of a dashboard of the cockpit of a metropolitan train and a real seat. The geometry of the dashboard has been acquired through Reverse Engineering techniques from a real train dashboard. The user’s immersion in the virtual environment during the simulation is guaranteed by the scene displayed on the Augmented Reality device, while, simultaneously, the stereoscopic projection on a screen above the dashboard makes available the experience even to users not directly involved, seeing the scene from the driver’s point of view. The immersive Augmented Reality is realized through a Head-Mounted Display (HMD) by which the user, protagonist of the driving experience, sees the configuration of the virtual control devices (CAD geometries) overlapped with the physical dashboard in order to naturally interact into the immersive environment. The interaction between user and simulator happens through the NUI (Natural User Interfaces) based on markerless tracking of parts of the user’s body

    Concept design, virtual prototyping and ergonomic analysis of an innovative skidding winch using a des-TRIZ approach

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    The main objective of this work was to design an innovative skidding winch aimed to improve timber harvesting productivity, operators' safety, and reduce environmental damage in contexts in which mechanized harvesting is limited. The study area is the north-western Black Sea region of Turkey. In the proposed methodology, the harvesting process was simulated with Discrete Event Simulation (DES) software in order to identify bottlenecks. An alternative process was compared with the original one within the DES software itself in order to validate further steps oriented to generate new innovative product concepts. The development of the product was focused towards customer satisfaction, collecting customer requirements and identifying quality characteristics with a Quality Function Deployment approach. Contradictions identified in the design phase were solved using the TRIZ contradiction toolkit, generating different product concepts. Inventive solutions provided by TRIZ were designed within parametric CAD software. The concepts were compared in virtual environment with focus on ergonomics, selecting an optimal solution. The results show that with the concept adopted is possible to achieve a substantial increase in productivity, from 121% to 133%, in terms of kilograms of logs per hour deposited on the landing. Moreover, the final concept allows for ergonomic loading operations and reduces environmental damage to soil and vegetation

    Coseismic extension recorded within the damage zone of the Vado di Ferruccio Thrust Fault, Central Apennines, Italy

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    Recent high resolution hypocentral localisation along active fault systems in the Central Apennines illuminates the activation of seismogenic volumes dipping at low angle (<30\ub0) in extensional settings overprinting contractional deformations affecting the continental crust of the Adria microplate. Individuation of the geological structures and of the fault processes associated with these seismic patterns will contribute to the interpretation of seismic sequence evolution, and seismic hazard studies. Here we report field and microstructural evidence of seismogenic extensional faults localized within pre-existing thrust fault zones. The Vado di Ferruccio Thrust Fault (VFTF) is a narrow fault zone (<2.5 m thick fault core) in the Central Apennines of Italy, accommodating 3c1 km of shortening during Miocene-Pliocene and exhumed from <3.5 km depth. In the thrust zone, exposures throughout the Fornaca Tectonic Window show Late Triassic bituminous dolostones thrust over Middle Jurassic interlayered carbonates upon a SSW-dipping fault. Isoclinal folds are dragged and sheared by thrust-parallel reverse faults in the footwall block whereas NW-striking faults occur within the hanging wall. Fault core observations are consistent with stable pressure solution-mediated aseismic sliding towards N024\ub0 during thrusting, with cyclic veining and faulting. Later extension has been accommodated at the regional scale by major normal faults cutting through the VFTF, while veins and pressure-solution seams crosscut the microstructures associated with thrusting and record the extensional stress regime within the thrust fault core. Lenses of shattered rocks (up to 10 s m thick), cut by a dense network of small displacement (<1.2 m) mirror-like normal faults, are reported in the hangingwall of the VFTF. These minor faults, related to a sharp principal slipping surface on the upper margin of the VFTF fault core, are interpreted as fossil evidence of microseismicity compartmentalized within the hanging wall of the VFTF. Synthetic and antithetic normal faults within the VFTF hangingwall damage zone are geometrically and kinematically similar to small earthquake ruptures (Mw < 2) in the hangingwall of low angle structures such as the thrust flats illuminated during the 2009 Mw 6.1 L'Aquila seismic sequence
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