Spectral characterizations and antibacterial effect of 2-(5-R-1H-benzimidazol-2-YL)-4-methyl/bromo-phenols and some metal complexes

2-(5-H/Cl/Me/NO2-1H-benzimidazol-2-yl)-4-Me/Br-phenols (HL1–HL5) were synthesized. HL1 complexes with Cu(NO3)2, AgNO3, Zn(ClO4)2 and; HL4, HL5 complexes with Zn(ClO4)2 were prepared. The structures of the compounds were confirmed on the basis of elemental analysis, molar conductivity, magnetic moment, FT-IR, 1H- and 13C-NMR. Antibacterial activity of the ligands and the complexes were evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimal inhibitory concentration (MIC) dilution method, against nine bacteria, and the results were compared with penicillin–G and oxytetracycline. While HL1 ligand has considerable antibacterial activity on B. cereus only; it’s Ag(I) complex show antibacterial effect toward almost all the bacteria. It is highly interesting that HL5 and [Zn(HL5)(L5)]ClO4 exhibit considerable high antibacterial activity toward K. pneumoniae, B. cereus, S. epidermidis and B. subtilis. KEY WORDS: Benzimidazole, Phenol, Metal complexes, Antibacterial activity  Bull. Chem. Soc. Ethiop. 2010, 24(3), 391-400

Preparation, characterization and antibacterial effect of 2-methoxy-6-(5-H/Me/Cl/NO2-1H-benzimidazol-2-yl)phenols and some transition metal complexes

2-Methoxy-6-(5-H/methyl/chloro/nitro-1H-benzimidazol-2-yl)phenols (HLx; x = 1–4, respectively) ligands and HL1 complexes with Fe(NO3)3, Cu(NO3)2, AgNO3 and Zn(NO3)2 were synthesized and characterized. The structures of the compounds were confirmed based on elemental analysis, molar conductivity, magnetic moment, FT-IR, 1H- and 13C-NMR. The antibacterial activity and minimum inhibitory concentration (MIC) of the free ligands, their hydrochloride salts and the complexes were evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) and the dilution method, respectively, against 9 bacteria. HL1 and HL3, as well as the Cu(II) and Zn(II) complexes, showed antibacterial activity against Gram-positive bacteria

In vitro Evaluation of Antimicrobial Activities of Salvia verticillata and Phlomis pungens

This study, the methanol extracts of Salvia verticillata L subsp. amasiaca (Freyn & Bornm) Bornm. and Phlomis pungens Willd. var. hirta Velen from flowers and leaves have been studied for antimicrobial activity. Antibacterial activity of the methanol extracts was determined against 9 bacterial strains (Klebsiella pneumoniae ATCC 4352, Pseudomonas aeroginosa ATCC 27853, Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 29213. Staphylococcus epidermidis ATCC 12228. Bacillus cereus ATCC 11778. Salmonella enteritidis KUEN 349, Proteus mirabilis CCM 1944, Escherichia coli ATCC 25922) using the macro broth dilution method. The methanol extract of the leaves and flowers of Salvia verticillata remarkably inhibited the growth of Pseudomonas aeruginosa, Salmonella enteritidis, Escherichia coli. Bacillus cereus. Bacillus subtilis and Staphylococcus aureus. On the other hand. the results indicate that the methanol extract of the leaves and flowers of Phlomis pungens remarkably inhibited the growth of Pseudomonas aeruginosa and Bacillus subtilis. In conclusion. the results show that Salvia verticillata and Phlomis pungens methanol extracts might be an alternative to antimicrobials in various infectious diseases

Recovery of dermatophytes in pet grooming tools from veterinary clinics and pet grooming salons

OBJECTIVES: Fomites such as brushes and clippers are known to be potential risk factors for the transmission of dermatophytes between pet animals. The aim of this study was to investigate this risk by examining those grooming implements for the presence of any viable dermatophytes

Paratuberculosis in cattle in Turkey detected by PCR

In this study 96 randomly selected fecal samples of two-year old or older cattle from Trakya district of Turkey were investigated for the presence of Mycobacterium avium subsp. Paratuberculosis by PCR. A pair of genus specific primers, derived from the IS 900 gene of the agent was used as a target sequence for the PCR. The specific DNA was not detected in any of the 96 fecal samples and all of them were considered to be PCR negative. In conclusion, although the absence of specific DNA in the samples of cattle raised in the Trakya districts is an optimistic sign, further studies on John's disease are needed

Preparation, characterization and antibacterial effect of 2-methoxy-6-(5-H/Me/Cl/NO2-1H-benzimidazol-2-yl)phenols and some transition metal complexes

2-Methoxy-6-(5-H/methyl/chloro/nitro-1H-benzimidazol-2-yl)phenols (HLx; x = 1-4, respectively) ligands and HL1 complexes with Fe(NO3)(3), Cu(NO3)(2), AgNO3 and Zn(NO3)(2) were synthesized and characterized. The structures of the compounds were confirmed based on elemental analysis, molar conductivity, magnetic moment, FT-IR, H-1- and C-13-NMR. The antibacterial activity and minimum inhibitory concentration (MIC) of the free ligands, their hydrochloride salts and the complexes were evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) and the dilution method, respectively, against 9 bacteria. HL1 and HL3, as well as the Cu(II) and Zn(II) complexes, showed antibacterial activity against Gram-positive bacteria

Spectral Characterization and Antibacterial Effect of 2-Methyl-6-(5-H/Me/Cl/NO2-1H-Benzimidazol-2-yl)-Phenols and Some Transition Metal Complexes

2-Methyl-6-(5-H/methyl/chloro/nitro-1H-benzimidazol-2-yl)-phenols (HLx : x = 1-4) ligands and HL1 complexes with Fe(NO3)(3), Cu(NO3)(2), AgNO3, Zn(NO3)(2) have been synthesized and characterized. The structures of the compounds were confirmed on the basis of elemental analysis, molar conductivity, magnetic moment, FT-IR, H-1- and C-13-NMR. Antibacterial activity of the free ligands, their hydrochloride salts and the complexes were evaluated using the disk diffusion method in dimethyl sulfoxide as well as the minimum inhibitory concentration dilution method, against nine bacteria. While HL1 ligand has not any activity, it's Ag(I) complex show antibacterial effect toward almost to all the bacteria. Zn(II) complex has antibacterial effect on especially K. pneumoniae, S. epidermidis and S. aureus bacteria

Synthesis, characterization, and antibacterial effect of 4-methoxy-2-(5-H/Me/Cl/NO2-1H-benzimidazol-2-yl)-phenols and some transition metal complexes

4-Methoxy-2-(5-H/methyl/chloro/nitro-1H-benzimidazol-2-yl)-phenol (HLX; X=1-4) ligands and HL1 complexes with Fe(NO3)(3), Cu(NO3)(2), AgNO3, and Zn(NO3)(2) were synthesized and characterized. The structures of the compounds were confirmed on the basis of elemental analysis, molar conductivity, magnetic moment, FT-IR, UV-visible, and H-1- and C-13-NMR. Antibacterial activity of the free ligands, their hydrochloride salts, and the complexes was evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimum inhibitory concentration (MIC) dilution method, against 9 bacteria, and the results were compared with penicillin-G and oxytetracycline. It was observed that HL1, [Ag(HL1)](NO3), and [Cu(L-1)(2)](H2O)(2) are effective on S. epidermidis, S. aureus, and B. subtilis (gram+) organisms compared with the other compounds. All compounds except HL4 and [Zn(L-1)(H2O)(2)]NO3 showed antibacterial activity on S. aureus