13 research outputs found

    Psychometrics: From practice to theory and back

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    nonparametric IRT, NIRT, latent unidimensionality, latent multidimensionality, essential unidimensionality, monotone locally independent unidimensional IRT model, MLI1, item pair conditional covariances, DIMTEST, HCA/CCPROX, DETECT, CONCOV, Mokken scaling, generalized compensatory model, approximate simple structure, DIF, differential item functioning, differential bundle functioning DBF, valid subtest, multidimensional model for DIF, MMD, SIBTEST, MultiSIB, Mantel-Haenszel, PolySIB, CrossingSIB, skills diagnosis, formative assessment, Unified Model, reparameterized Bayes Unified Model, MCMC, evidence centered design, ECD, PSAT Score Report Plus,

    Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma

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    Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma, and variability in IOP might herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multi-ancestry participants for IOP. We confirm genetic association of known loci for IOP and primary open-angle glaucoma (POAG) and identify four new IOP-associated loci located on chromosome 3q25.31 within the FNDC3B gene (P = 4.19 × 10 '8 for rs6445055), two on chromosome 9 (P = 2.80 × 10 '11 for rs2472493 near ABCA1 and P = 6.39 × 10 '11 for rs8176693 within ABO) and one on chromosome 11p11.2 (best P = 1.04 × 10 '11 for rs747782). Separate meta-analyses of 4 independent POAG cohorts, totaling 4,284 cases and 95,560 controls, showed that 3 of these loci for IOP were also associated with POAG
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