962 research outputs found
Benchmark Transiting Brown Dwarf LHS 6343 C: <em>Spitzer</em> Secondary Eclipse Observations Yield Brightness Temperature and Mid-T Spectral Class
Spin oscillations in transient diffusion of a spin pulse in n-type semiconductor quantum wells
By studying the time and spatial evolution of a pulse of the spin
polarization in -type semiconductor quantum wells, we highlight the
importance of the off-diagonal spin coherence in spin diffusion and transport.
Spin oscillations and spin polarization reverse along the the direction of spin
diffusion in the absence of the applied magnetic field are predicted from our
investigation.Comment: 5 pages, 4 figures, accepted for publication in PR
Structure Formation, Melting, and the Optical Properties of Gold/DNA Nanocomposites: Effects of Relaxation Time
We present a model for structure formation, melting, and optical properties
of gold/DNA nanocomposites. These composites consist of a collection of gold
nanoparticles (of radius 50 nm or less) which are bound together by links made
up of DNA strands. In our structural model, the nanocomposite forms from a
series of Monte Carlo steps, each involving reaction-limited cluster-cluster
aggregation (RLCA) followed by dehybridization of the DNA links. These links
form with a probability which depends on temperature and particle
radius . The final structure depends on the number of monomers (i. e. gold
nanoparticles) , , and the relaxation time. At low temperature, the
model results in an RLCA cluster. But after a long enough relaxation time, the
nanocomposite reduces to a compact, non-fractal cluster. We calculate the
optical properties of the resulting aggregates using the Discrete Dipole
Approximation. Despite the restructuring, the melting transition (as seen in
the extinction coefficient at wavelength 520 nm) remains sharp, and the melting
temperature increases with increasing as found in our previous
percolation model. However, restructuring increases the corresponding link
fraction at melting to a value well above the percolation threshold. Our
calculated extinction cross section agrees qualitatively with experiments on
gold/DNA composites. It also shows a characteristic ``rebound effect,''
resulting from incomplete relaxation, which has also been seen in some
experiments. We discuss briefly how our results relate to a possible sol-gel
transition in these aggregates.Comment: 12 pages, 10 figure
Theory of Melting and the Optical Properties of Gold/DNA Nanocomposites
We describe a simple model for the melting and optical properties of a
DNA/gold nanoparticle aggregate. The optical properties at fixed wavelength
change dramatically at the melting transition, which is found to be higher and
narrower in temperature for larger particles, and much sharper than that of an
isolated DNA link. All these features are in agreement with available
experiments. The aggregate is modeled as a cluster of gold nanoparticles on a
periodic lattice connected by DNA bonds, and the extinction coefficient is
computed using the discrete dipole approximation. Melting takes place as an
increasing number of these bonds break with increasing temperature. The melting
temperature corresponds approximately to the bond percolation threshold.Comment: 5 pages, 4 figure. To be published in Phys. Rev.
When to be discrete: the importance of time formulation in understanding animal movement
Animal movement is essential to our understanding of population dynamics, animal behavior, and the impacts of global change. Coupled with high-resolution biotelemetry data, exciting new inferences about animal movement have been facilitated by various specifications of contemporary models. These approaches differ, but most share common themes. One key distinction is whether the underlying movement process is conceptualized in discrete or continuous time. This is perhaps the greatest source of confusion among practitioners, both in terms of implementation and biological interpretation. In general, animal movement occurs in continuous time but we observe it at fixed discrete-time intervals. Thus, continuous time is conceptually and theoretically appealing, but in practice it is perhaps more intuitive to interpret movement in discrete intervals. With an emphasis on state-space models, we explore the differences and similarities between continuous and discrete versions of mechanistic movement models, establish some common terminology, and indicate under which circumstances one form might be preferred over another. Counter to the overly simplistic view that discrete- and continuous-time conceptualizations are merely different means to the same end, we present novel mathematical results revealing hitherto unappreciated consequences of model formulation on inferences about animal movement. Notably, the speed and direction of movement are intrinsically linked in current continuous-time random walk formulations, and this can have important implications when interpreting animal behavior. We illustrate these concepts in the context of state-space models with multiple movement behavior states using northern fur seal (Callorhinus ursinus) biotelemetry data
Magnetic fields in protoplanetary disks
Magnetic fields likely play a key role in the dynamics and evolution of
protoplanetary discs. They have the potential to efficiently transport angular
momentum by MHD turbulence or via the magnetocentrifugal acceleration of
outflows from the disk surface, and magnetically-driven mixing has implications
for disk chemistry and evolution of the grain population. However, the weak
ionisation of protoplanetary discs means that magnetic fields may not be able
to effectively couple to the matter. I present calculations of the ionisation
equilibrium and magnetic diffusivity as a function of height from the disk
midplane at radii of 1 and 5 AU. Dust grains tend to suppress magnetic coupling
by soaking up electrons and ions from the gas phase and reducing the
conductivity of the gas by many orders of magnitude. However, once grains have
grown to a few microns in size their effect starts to wane and magnetic fields
can begin to couple to the gas even at the disk midplane. Because ions are
generally decoupled from the magnetic field by neutral collisions while
electrons are not, the Hall effect tends to dominate the diffusion of the
magnetic field when it is able to partially couple to the gas.
For a standard population of 0.1 micron grains the active surface layers have
a combined column of about 2 g/cm^2 at 1 AU; by the time grains have aggregated
to 3 microns the active surface density is 80 g/cm^2. In the absence of grains,
x-rays maintain magnetic coupling to 10% of the disk material at 1 AU (150
g/cm^2). At 5 AU the entire disk thickness becomes active once grains have
aggregated to 1 micron in size.Comment: 11 pages, 11 figs, aastex.cls. Accepted for publication in
Astrophysics & Space Science. v3 corrects bibliograph
Combined kinase inhibitors of MEK1/2 and either PI3K or PDGFR are efficacious in intracranial triple-negative breast cancer
Background: Triple-negative breast cancer (TNBC), lacking expression of hormone and human epidermal growth factor receptor 2 receptors, is an aggressive subtype that frequently metastasizes to the brain and has no FDA-approved systemic therapies. Previous literature demonstrates mitogen-Activated protein kinase kinase (MEK) pathway activation in TNBC brain metastases. Thus, we aimed to discover rational combinatorial therapies with MEK inhibition, hypothesizing that co-inhibition using clinically available brain-penetrant inhibitors would improve survival in preclinical models of TNBC brain metastases. Methods: Using human-derived TNBC cell lines, synthetic lethal small interfering RNA kinase screens were evaluated with brain-penetrant inhibitors against MEK1/2 (selumetinib, AZD6244) or phosphatidylinositol-3 kinase (PI3K; buparlisib, BKM120). Mice bearing intracranial TNBC tumors (SUM149, MDA-MB-231Br, MDA-MB-468, or MDA-MB-436) were treated with MEK, PI3K, or platelet derived growth factor receptor (PDGFR; pazopanib) inhibitors alone or in combination. Tumors were analyzed by western blot and multiplexed kinase inhibitor beads/mass spectrometry to assess treatment effects. Results: Screens identified MEK+PI3K and MEK+PDGFR inhibitors as tractable, rational combinations. Dual treatment of selumetinib with buparlisib or pazopanib was synergistic in TNBC cells in vitro. Both combinations improved survival in intracranial SUM149 and MDA-MB-231Br, but not MDA-MB-468 or MDA-MB-436. Treatments decreased mitogen-Activated protein kinase (MAPK) and PI3K (Akt) signaling in sensitive (SUM149 and 231Br) but not resistant models (MDA-MB-468). Exploratory analysis of kinome reprogramming in SUM149 intracranial tumors after MEK PI3K inhibition demonstrates extensive kinome changes with treatment, especially in MAPK pathway members. Conclusions: Results demonstrate that rational combinations of the clinically available inhibitors selumetinib with buparlisib or pazopanib may prove to be promising therapeutic strategies for the treatment of some TNBC brain metastases. Additionally, effective combination treatments cause widespread alterations in kinase pathways, including targetable potential resistance drivers
Combining Exploration and Exploitation in Active Learning
This thesis investigates the active learning in the presence of model bias. State of the art approaches advocate combining exploration and exploitation in active learning. However, they suffer from premature exploitation or unnecessary exploration in the later stages of learning. We propose to combine exploration and exploitation in active learning by discarding instances outside a sampling window that is centered around the estimated decision boundary and uniformly draw sample from this window. Initially the window spans the entire feature space and is gradually constricted, where the rate of constriction models the exploration-exploitation tradeoff. The desired effect of this approach (CExp) is that we get an increasing sampling density in informative regions as active learning progresses, resulting in a continuous and natural transition from exploration to exploitation, limiting both premature exploitation and unnecessary exploration. We show that our approach outperforms state of the art on real world multiclass datasets. We also extend our approach to spatial mapping problems where the standard active learning assumption of uniform costs is violated. We show that we can take advantage of \emph{spatial continuity} in the data by geographically partitioning the instances in the sampling window and choosing a single partition (region) for sampling, as opposed to taking a random sample from the entire window, resulting in a novel spatial active learning algorithm that combines exploration and exploitation. We demonstrate that our approach (CExp-Spatial) can generate cost-effective sampling trajectories over baseline sampling methods. Finally, we present the real world problem of mapping benthic habitats where bathymetry derived features are typically not strong enough to discriminate the fine details between classes identified from high-resolution imagery, increasing the possiblity of model bias in active learning. We demonstrate, under such conditions, that CExp outperforms state of the art and that CExp-Spatial can generate more cost-effective sampling trajectories for an Autonomous Underwater Vehicle in contrast to baseline sampling strategies
Spin-polarized current amplification and spin injection in magnetic bipolar transistors
The magnetic bipolar transistor (MBT) is a bipolar junction transistor with
an equilibrium and nonequilibrium spin (magnetization) in the emitter, base, or
collector. The low-injection theory of spin-polarized transport through MBTs
and of a more general case of an array of magnetic {\it p-n} junctions is
developed and illustrated on several important cases. Two main physical
phenomena are discussed: electrical spin injection and spin control of current
amplification (magnetoamplification). It is shown that a source spin can be
injected from the emitter to the collector. If the base of an MBT has an
equilibrium magnetization, the spin can be injected from the base to the
collector by intrinsic spin injection. The resulting spin accumulation in the
collector is proportional to , where is the proton
charge, is the bias in the emitter-base junction, and is the
thermal energy. To control the electrical current through MBTs both the
equilibrium and the nonequilibrium spin can be employed. The equilibrium spin
controls the magnitude of the equilibrium electron and hole densities, thereby
controlling the currents. Increasing the equilibrium spin polarization of the
base (emitter) increases (decreases) the current amplification. If there is a
nonequilibrium spin in the emitter, and the base or the emitter has an
equilibrium spin, a spin-valve effect can lead to a giant magnetoamplification
effect, where the current amplifications for the parallel and antiparallel
orientations of the the equilibrium and nonequilibrium spins differ
significantly. The theory is elucidated using qualitative analyses and is
illustrated on an MBT example with generic materials parameters.Comment: 14 PRB-style pages, 10 figure
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