45 research outputs found

    Hsp70 in mitochondrial biogenesis

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    The family of hsp70 (70 kilodalton heat shock protein) molecular chaperones plays an essential and diverse role in cellular physiology, Hsp70 proteins appear to elicit their effects by interacting with polypeptides that present domains which exhibit non-native conformations at distinct stages during their life in the cell. In this paper we review work pertaining to the functions of hsp70 proteins in chaperoning mitochondrial protein biogenesis. Hsp70 proteins function in protein synthesis, protein translocation across mitochondrial membranes, protein folding and finally the delivery of misfolded proteins to proteolytic enzymes in the mitochondrial matrix

    The pole structure of the unitary, crossing symmetric low energy ππ\pi\pi scattering amplitudes

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    The pole structure of the low energy ππ\pi\pi scattering amplitudes is studied using a proper chiral unitarization method combined with crossing symmetry and the low energy phase shift data. It is found that the σ\sigma pole position is at Mσ=470±50MeVM_\sigma=470\pm 50MeV, Γσ=570±50MeV\Gamma_\sigma=570\pm 50MeV. The existence of the virtual state pole in the IJ=20 channel is reconfirmed. Various threshold parameters are estimated and are found in general in good agreement with the results obtained from the Roy equation analyses.Comment: Minor corrections made and references added. Final version accepted for publication as JHEP02(2005)04

    Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis

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    Measurement of prompt D0^{0} and D\overline{D}0^{0} meson azimuthal anisotropy and search for strong electric fields in PbPb collisions at root SNN\sqrt{S_{NN}} = 5.02 TeV

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    The strong Coulomb field created in ultrarelativistic heavy ion collisions is expected to produce a rapiditydependent difference (Av2) in the second Fourier coefficient of the azimuthal distribution (elliptic flow, v2) between D0 (uc) and D0 (uc) mesons. Motivated by the search for evidence of this field, the CMS detector at the LHC is used to perform the first measurement of Av2. The rapidity-averaged value is found to be (Av2) = 0.001 ? 0.001 (stat)? 0.003 (syst) in PbPb collisions at ?sNN = 5.02 TeV. In addition, the influence of the collision geometry is explored by measuring the D0 and D0mesons v2 and triangular flow coefficient (v3) as functions of rapidity, transverse momentum (pT), and event centrality (a measure of the overlap of the two Pb nuclei). A clear centrality dependence of prompt D0 meson v2 values is observed, while the v3 is largely independent of centrality. These trends are consistent with expectations of flow driven by the initial-state geometry. ? 2021 The Author. Published by Elsevier B.V. This is an open access article under the CC BY licens

    “Illuminating” echinocandins' mechanism of action

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    10.1021/acscentsci.0c01222ACS Central Science6101651-165

    Performance Visualization on Monsoon

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    Carbon nanotubes for delivery of small molecule drugs

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    10.1016/j.addr.2013.08.005Advanced Drug Delivery Reviews65151964-2015ADDR
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