Resonant nonstationary amplification of polychromatic laser pulses and conical emission in an optically dense ensemble of neon metastable atoms

Experimental and numerical investigation of single-beam and pump-probe interaction with a resonantly absorbing dense extended medium under strong and weak field-matter coupling is presented. Significant probe beam amplification and conical emission were observed. Under relatively weak pumping and high medium density, when the condition of strong coupling between field and resonant matter is fulfilled, the probe amplification spectrum has a form of spectral doublet. Stronger pumping leads to the appearance of a single peak of the probe beam amplification at the transition frequency. The greater probe intensity results in an asymmetrical transmission spectrum with amplification at the blue wing of the absorption line and attenuation at the red one. Under high medium density, a broad band of amplification appears. Theoretical model is based on the solution of the Maxwell-Bloch equations for a two-level system. Different types of probe transmission spectra obtained are attributed to complex dynamics of a coherent medium response to broadband polychromatic radiation of a multimode dye laser.Comment: 9 pages, 13 figures, corrected, Fig.8 was changed, to be published in Phys. Rev.

Metal enrichment processes

There are many processes that can transport gas from the galaxies to their environment and enrich the environment in this way with metals. These metal enrichment processes have a large influence on the evolution of both the galaxies and their environment. Various processes can contribute to the gas transfer: ram-pressure stripping, galactic winds, AGN outflows, galaxy-galaxy interactions and others. We review their observational evidence, corresponding simulations, their efficiencies, and their time scales as far as they are known to date. It seems that all processes can contribute to the enrichment. There is not a single process that always dominates the enrichment, because the efficiencies of the processes vary strongly with galaxy and environmental properties.Comment: 18 pages, 8 figures, accepted for publication in Space Science Reviews, special issue "Clusters of galaxies: beyond the thermal view", Editor J.S. Kaastra, Chapter 17; work done by an international team at the International Space Science Institute (ISSI), Bern, organised by J.S. Kaastra, A.M. Bykov, S. Schindler & J.A.M. Bleeke

Steps toward Determination of the Size and Structure of the Broad-Line Region in Active Galactic Nuclei. XI. Intensive Monitoring of the Ultraviolet Spectrum of NGC 7469

From 1996 June 10 to July 29, the International Ultraviolet Explorer monitored the Seyfert 1 galaxy NGC 7469 continuously in an attempt to measure time delays between the continuum and emission-line fluxes. From the time delays, one can estimate the size of the region dominating the production of the UV emission lines in this source. We find the strong UV emission lines to respond to continuum variations with time delays of about 2.d3-3.d1 for Lyα, 2.d7 for C IV λ1549, 1.d9-2.d4 for N IV λ 1240, 1.d7-1.d8 for Si IV λ 1400, and 0.d7-1.d0 for He II λ1640. The most remarkable result, however, is the detection of apparent time delays between the different UV continuum bands. With respect to the UV continuum flux at 1315 Å, the flux at 1485 Å, 1740 Å, and 1825 Å lags with time delays of 0.d21, 0.d35, and 0.d28, respectively. Determination of the significance of this detection is somewhat problematic since it depends on accurate estimation of the uncertainties in the lag measurements, which are difficult to assess. We attempt to estimate the uncertainties in the time delays through Monte Carlo simulations, and these yield estimates of ~0.d07 for the 1 σ uncertainties in the interband continuum time delays. Possible explanations for the delays include the existence of a continuum-flux reprocessing region close to the central source and/or a contamination of the continuum flux with a very broad time-delayed emission feature such as the Balmer continuum or merged Fe II multiplets

Deleterious, protein-altering variants in the transcriptional coregulator ZMYM3 in 27 individuals with a neurodevelopmental delay phenotype.

Neurodevelopmental disorders (NDDs) result from highly penetrant variation in hundreds of different genes, some of which have not yet been identified. Using the MatchMaker Exchange, we assembled a cohort of 27 individuals with rare, protein-altering variation in the transcriptional coregulator ZMYM3, located on the X chromosome. Most (n = 24) individuals were males, 17 of which have a maternally inherited variant; six individuals (4 male, 2 female) harbor de novo variants. Overlapping features included developmental delay, intellectual disability, behavioral abnormalities, and a specific facial gestalt in a subset of males. Variants in almost all individuals (n = 26) are missense, including six that recurrently affect two residues. Four unrelated probands were identified with inherited variation affecting Arg441, a site at which variation has been previously seen in NDD-affected siblings, and two individuals have de novo variation resulting in p.Arg1294Cys (c.3880C>T). All variants affect evolutionarily conserved sites, and most are predicted to damage protein structure or function. ZMYM3 is relatively intolerant to variation in the general population, is widely expressed across human tissues, and encodes a component of the KDM1A-RCOR1 chromatin-modifying complex. ChIP-seq experiments on one variant, p.Arg1274Trp, indicate dramatically reduced genomic occupancy, supporting a hypomorphic effect. While we are unable to perform statistical evaluations to definitively support a causative role for variation in ZMYM3, the totality of the evidence, including 27 affected individuals, recurrent variation at two codons, overlapping phenotypic features, protein-modeling data, evolutionary constraint, and experimentally confirmed functional effects strongly support ZMYM3 as an NDD-associated gene