Computational codon optimization of synthetic gene for protein expression

10.1186/1752-0509-6-134BMC Systems Biology6

3-D Perturbations in Conformal Turbulence

The effects of three-dimensional perturbations in two-dimensional turbulence are investigated, through a conformal field theory approach. We compute scaling exponents for the energy spectra of enstrophy and energy cascades, in a strong coupling limit, and compare them to the values found in recent experiments. The extension of unperturbed conformal turbulence to the present situation is performed by means of a simple physical picture in which the existence of small scale random forces is closely related to deviations of the exact two-dimensional fluid motion.Comment: Discussion of intermittency improved. Figure include

Conformal Turbulence with Boundary

Based upon the formalism of conformal field theory with a boundary, we give a description of the boundary effect on fully developed two dimensional turbulence. Exact one and two point velocity correlation functions and energy power spectrum confined in the upper half plane are obtained using the image method. This result enables us to address the infrared problem of the theory of conformal turbulence.Comment: 10pages, KHTP-93-01, SNUCTP-93-0

A Review of Discharge Medications in Patients Admitted with Acute Decompesated Heart Failure in a Tertiary Referral Centre

Background: National guidelines for heart failure recommend prescription of certain classes of drugs to improve prognosis in patients admitted with acute decompensated heart failure (ADHF). It has been noted during clinical follow up such patients are discharged with different treatment regimes. Objective: To determine the relationship between drug treatment regimes in patients admitted to a tertiary referral centre with ADHF and their medium term clinical outcomes post-discharge, defined as 90-day mortality and hospital readmissions. Methods: 94 cases with a discharge diagnosis of ADHF were recruited from October 2017 until August 2018. Cases were analyzed retrospectively for their medications at discharge. Patients were followed-up for 90 days via phone. Results: Out of 94 patients, 8 patients died during admission. 86 patients were being analysed for clinical outcomes. 22 (26%) patients were discharged without a single type of guideline recommended medication for heart failure (GRM). 33 (38%) patients were discharged on one type, 22 (26%) patients discharged with two types and 10 (12%) patients were discharged with three or more types of GRM. The main reasons for not being discharged with all GRM were chronic kidney disease, obstructive lung disease, bradycardia and hypotension. The 90 days mortality rate was higher in patients discharged with ≤1 class of GRM drugs compared to patients with discharged on ≥2 classes of GRM drugs. (14.5% vs 6.5%; OR 2.25; 95%CI 0.51, 9.96; p=0.28). The 90 days readmission rate for ADHF was also higher for patients discharged with ≤1 class of GRM drugs (20.0% vs 12.9%; OR 1.55; 95%CI 0.539, 4.457; p=0.416). Overall, patients with discharged with ≤1 class of GRM drugs had also a higher 90-day event rate (27.3% vs 19.4%; OR 1.78; 95%CI 0.797, 3.993; p=0.16). Conclusions: Discharging ADHF patients with ≥2 class of GRM drugs was associated with lower 90 days readmission rates and mortality

Review of time in therapeutic range of warfarin in a tertiary centre in Malaysia

Anticoagulation management is a recognized challenge in medical care. Complications of supratherapeutic anticoagulation are hemorrhagic stroke, major bleeding, and death. There is an even greater risk of ischemic stroke in AF, worsening of VTE associated with subtherapeutic dosing

Chern-Simons Vortices in Supergravity

We study supersymmetric vortex solutions in three-dimensional abelian gauged supergravity. First, we construct the general U(1)-gauged D=3, N=2 supergravity whose scalar sector is an arbitrary Kahler manifold with U(1) isometry. This construction clarifies the connection between local supersymmetry and the specific forms of some scalar potentials previously found in the literature -- in particular, it provides the locally supersymmetric embedding of the abelian Chern-Simons Higgs model. We show that the Killing spinor equations admit rotationally symmetric vortex solutions with asymptotically conical geometry which preserve half of the supersymmetry.Comment: 26 pages, LaTeX2

The road to deterministic matrices with the restricted isometry property

The restricted isometry property (RIP) is a well-known matrix condition that provides state-of-the-art reconstruction guarantees for compressed sensing. While random matrices are known to satisfy this property with high probability, deterministic constructions have found less success. In this paper, we consider various techniques for demonstrating RIP deterministically, some popular and some novel, and we evaluate their performance. In evaluating some techniques, we apply random matrix theory and inadvertently find a simple alternative proof that certain random matrices are RIP. Later, we propose a particular class of matrices as candidates for being RIP, namely, equiangular tight frames (ETFs). Using the known correspondence between real ETFs and strongly regular graphs, we investigate certain combinatorial implications of a real ETF being RIP. Specifically, we give probabilistic intuition for a new bound on the clique number of Paley graphs of prime order, and we conjecture that the corresponding ETFs are RIP in a manner similar to random matrices.Comment: 24 page

Problems with Time-Varying Extra Dimensions or "Cardassian Expansion" as Alternatives to Dark Energy

It has recently been proposed that the Universe might be accelerating as a consequence of extra dimensions with time varying size. We show that although these scenarios can lead to acceleration, they run into serious difficulty when taking into account limits on the time variation of the four dimensional Newton's constant. On the other hand, models of ``Cardassian'' expansion based on extra dimensions which have been constructed so far violate the weak energy condition for the bulk stress energy, for parameters that give an accelerating universe.Comment: 8 pages, minor changes. To appear in Physical Review

Complementarity of the CERN Large Hadron Collider and the e+e−e^+e^- International Linear Collider

The next-generation high-energy facilities, the CERN Large Hadron Collider (LHC) and the prospective $e^+e^-$ International Linear Collider (ILC), are expected to unravel new structures of matter and forces from the electroweak scale to the TeV scale. In this report we review the complementary role of LHC and ILC in drawing a comprehensive and high-precision picture of the mechanism breaking the electroweak symmetries and generating mass, and the unification of forces in the frame of supersymmetry.Comment: 14 pages, 17 figures, to be published in "Supersymmetry on the Eve of the LHC", a special volume of European Physical Journal C, Particles and Fields (EPJC) in memory of Julius Wes