Topological orders and Edge excitations in FQH states

Fractional quantum Hall (FQH) liquids contain extremely rich internal structures which represent a whole new kind of ordering. We discuss characterization and classification of the new orders (which is called topological orders). We also discuss the edge excitations in FQH liquids, which form the so-called chiral Luttinger liquids. The chiral Luttinger liquids at the edges also have very rich structures as a reflection of the rich topological orders in the bulk. Thus, edge excitations provide us a practical way to measure topological orders in experiments.Comment: 67 pages, plain-tex, 3 figures. The section about spin vector was rewritten to make it more readabl

A dc voltage step-up transformer based on a bi-layer \nu=1 quantum Hall system

A bilayer electron system in a strong magnetic field at low temperatures, with total Landau level filling factor nu =1, can enter a strongly coupled phase, known as the (111) phase or the quantum Hall pseudospin-ferromagnet. In this phase there is a large quantized Hall drag resistivity between the layers. We consider here structures where regions of (111) phase are separated by regions in which one of the layers is depleted by means of a gate, and various of the regions are connected together by wired contacts. We note that with suitable designs, one can create a DC step-up transformer where the output voltage is larger than the input, and we show how to analyze the current flows and voltages in such devices

Relation between flux formation and pairing in doped antiferromagnets

We demonstrate that patterns formed by the current-current correlation function are landmarks which indicate that spin bipolarons form in doped antiferromagnets. Holes which constitute a spin bipolaron reside at opposite ends of a line (string) formed by the defects in the antiferromagnetic spin background. The string is relatively highly mobile, because the motion of a hole at its end does not raise extensively the number of defects, provided that the hole at the other end of the line follows along the same track. Appropriate coherent combinations of string states realize some irreducible representations of the point group C_4v. Creep of strings favors d- and p-wave states. Some more subtle processes decide the symmetry of pairing. The pattern of the current correlation function, that defines the structure of flux, emerges from motion of holes at string ends and coherence factors with which string states appear in the wave function of the bound state. Condensation of bipolarons and phase coherence between them puts to infinity the correlation length of the current correlation function and establishes the flux in the system.Comment: 5 pages, 6 figure

Critical points in edge tunneling between generic FQH states

A general description of weak and strong tunneling fixed points is developed in the chiral-Luttinger-liquid model of quantum Hall edge states. Tunneling fixed points are a subset of `termination' fixed points, which describe boundary conditions on a multicomponent edge. The requirement of unitary time evolution at the boundary gives a nontrivial consistency condition for possible low-energy boundary conditions. The effect of interactions and random hopping on fixed points is studied through a perturbative RG approach which generalizes the Giamarchi-Schulz RG for disordered Luttinger liquids to broken left-right symmetry and multiple modes. The allowed termination points of a multicomponent edge are classified by a B-matrix with rational matrix elements. We apply our approach to a number of examples, such as tunneling between a quantum Hall edge and a superconductor and tunneling between two quantum Hall edges in the presence of interactions. Interactions are shown to induce a continuous renormalization of effective tunneling charge for the integrable case of tunneling between two Laughlin states. The correlation functions of electronlike operators across a junction are found from the B matrix using a simple image-charge description, along with the induced lattice of boundary operators. Many of the results obtained are also relevant to ordinary Luttinger liquids.Comment: 23 pages, 6 figures. Xiao-Gang Wen: http://dao.mit.edu/~we

High-dose carfilzomib achieves superior anti-tumor activity over lowdose and recaptures response in relapsed/refractory multiple myeloma resistant to low-dose carfilzomib by co-inhibiting the β2 and β1 subunits of the proteasome complex

The optimal carfilzomib dosing is a matter of debate. We analyzed the inhibition profiles of proteolytic proteasome subunits β5, β2 and β1 after low-dose (20/27 mg/m2) versus high-dose (≥36 mg/m2) carfilzomib in 103 pairs of peripheral blood mononuclear cells from patients with relapsed/refractory (RR) multiple myeloma (MM). β5 activity was inhibited (median inhibition >50%) in vivo by 20 mg/m2, whereas β2 and β1 were co-inhibited only by 36 and 56 mg/m2, respectively. Co-inhibition of β2 (P=0.0001) and β1 activity (P=0.0005) differed significantly between high-dose and low-dose carfilzomib. Subsequently, high-dose carfilzomib showed significantly more effective proteasome inhibition than low-dose drug in vivo (P=0.0003). We investigated the clinical data of 114 patients treated with carfilzomib combinations. High-dose carfilzomib demonstrated a higher overall response rate (P=0.03) and longer progression-free survival (PFS) (P=0.007) than low-dose carfilzomib. Therefore, we escalated the carfilzomib dose to ≥ 36 mg/m2 in 16 patients who progressed during low-dose carfilzomib-containing therapies. High-dose carfilzomib recaptured response (≥ partial remission) in 9 (56%) patients with a median PFS of 4.4 months. Altogether, we provide the first in vivo evidence in RRMM patients that the molecular activity of high-dose carfilzomib differs from that of low-dose carfilzomib by co-inhibition of β2 and β1 proteasome subunits and, consequently, high-dose carfilzomib achieves a superior anti-MM effect than low-dose and recaptures response in RRMM being resistant to low-dose carfilzomib. The optimal carfilzomib dose should be ≥ 36 mg/m2 to reach a sufficient anti-tumor activity, while the balance between efficacy and tolerability should be considered in each patient.Bio-organic Synthesi

A limit for the mu -> e gamma decay from the MEG experiment

A search for the decay mu -> e gamma, performed at PSI and based on data from the initial three months of operation of the MEG experiment, yields an upper limit on the branching ratio of BR(mu -> e gamma) < 2.8 x 10**-11 (90% C.L.). This corresponds to the measurement of positrons and photons from ~ 10**14 stopped mu-decays by means of a superconducting positron spectrometer and a 900 litre liquid xenon photon detector.Comment: 13 pages, 9 figures. v2: improved estimate of photon reconstruction efficienc

Epstein-Barr virus: clinical and epidemiological revisits and genetic basis of oncogenesis

Epstein-Barr virus (EBV) is classified as a member in the order herpesvirales, family herpesviridae, subfamily gammaherpesvirinae and the genus lymphocytovirus. The virus is an exclusively human pathogen and thus also termed as human herpesvirus 4 (HHV4). It was the first oncogenic virus recognized and has been incriminated in the causation of tumors of both lymphatic and epithelial nature. It was reported in some previous studies that 95% of the population worldwide are serologically positive to the virus. Clinically, EBV primary infection is almost silent, persisting as a life-long asymptomatic latent infection in B cells although it may be responsible for a transient clinical syndrome called infectious mononucleosis. Following reactivation of the virus from latency due to immunocompromised status, EBV was found to be associated with several tumors. EBV linked to oncogenesis as detected in lymphoid tumors such as Burkitt's lymphoma (BL), Hodgkin's disease (HD), post-transplant lymphoproliferative disorders (PTLD) and T-cell lymphomas (e.g. Peripheral T-cell lymphomas; PTCL and Anaplastic large cell lymphomas; ALCL). It is also linked to epithelial tumors such as nasopharyngeal carcinoma (NPC), gastric carcinomas and oral hairy leukoplakia (OHL). In vitro, EBV many studies have demonstrated its ability to transform B cells into lymphoblastoid cell lines (LCLs). Despite these malignancies showing different clinical and epidemiological patterns when studied, genetic studies have suggested that these EBV- associated transformations were characterized generally by low level of virus gene expression with only the latent virus proteins (LVPs) upregulated in both tumors and LCLs. In this review, we summarize some clinical and epidemiological features of EBV- associated tumors. We also discuss how EBV latent genes may lead to oncogenesis in the different clinical malignancie

Detectable clonal mosaicism and its relationship to aging and cancer

In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of >2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 × 10(-8)). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free individuals (OR = 35.4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases

Polyculturalism and cultural adjustment of international students: Exploring the moderating role of cultural distance in a quantitative cross-sectional survey study

© 2019, © 2019 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license. For international students, adjusting to the culture of their host country is an essential and challenging task, and previous research has inquired into factors that relate to better adjustment of such students. The current study investigates the possible role of intergroup ideology of polyculturalism in international students’ cultural adjustment, and the effect of cultural distance to this relationship in international students in the University of Macau using a quantitative cross-sectional survey approach. We surveyed 319 international students from different countries that varied in cultural distance from Macau and asked about their endorsement of polyculturalism and their current cultural adjustment. Results showed that who have the greater endorsement of polyculturalism adjusted to the host culture (Macau) better. Multiple regression analysis showed that who had greater endorsement of polyculturalism and came from lower cultural distance societies adjusted to the host culture (Macau) better. Moreover, cultural distance acted as a moderator between polyculturalism and cultural adjustment; specifically, the positive association between polyculturalism and cultural adjustment was observed only when the cultural distance was low. Implications and future directions for theory and practice are discussed