373 research outputs found
PREPARATION AND IN VITRO EVALUATION OF CYCLODEXTRIN BASED EFFERVESCENT AND DISPERSIBLE GRANULES OF CARBAMAZEPINE
Objective: Carbamazepine is typically used for the treatment of seizure disorders and neuropathic pain. One of the major problems with this drug is its low solubility in water; therefore the objective of this study was to enhance the solubility of carbamazepine by complexation with cyclodextrin to be formulated as effervescent and dispersible granules.Methods: Solvent evaporation method was used to prepare, binary (Carbamazepine/β-cyclodextrin) complex and ternary (Carbamazepine/β-cyclodextrin/hydroxypropyl methyl cellulose (HPMC E5). The more soluble complex will be further formulated as unit dose effervescent and dispersible granules. The complexes were evaluated for their solubility, drug content, percentage practical yield and differential scanning calorimetery (DSC) to confirm the formation of the complex.Results: The ratio of effervescent components, amount of effervescent base, amount of croscarmellose sodium (superdisintegrant) within the formula were found to play a role in the percentage of drug dissolved. Among the all prepared formulas, the effervescent granules containing ternary complex equivalent to 200 or 100 carbamazepine with effervescent base of 1:2:3.4 citric acid: tartaric acid: sodium bicarbonate not less than 48% w/w and 3% w/w croscarmellose sodium within the formula may be considered as a promising formulas regarding the amount of drug dissolved within 5 min.Conclusion: The solubility of carbamazepine was enhanced by complexation with β-cyclodextrin and HPMC E5 as a ternary complex. Hence effervescent and dispersible granules of carbamazepine with good flow properties can be successfully prepared by using this complex
Implications of Recent Measurements of Hadronic Charmless B Decays
Implications of recent CLEO measurements of hadronic charmless B decays are
discussed. (i) Employing the Bauer-Stech-Wirbel (BSW) model for form factors as
a benchmark, the data indicate that the form factor
is smaller than that predicted by the BSW model, whereas the
data of imply that the form factors are greater than the BSW model's values. (ii) The tree-dominated
modes imply that the effective
number of colors N_c(LL) for (V-A)(V-A) operators is preferred to be smaller,
while the current limit on shows that N_c(LR)>3. The data of and clearly indicate that . (iii) In
order to understand the observed suppression of and
non-suppression of modes, both being governed by the form factor
, the unitarity angle is preferred to be greater than
. By contrast, the new measurement of no
longer strongly favors . (iv) The observed pattern K^-\pi^+\sim
\ov K^0\pi^-\sim {2\over 3}K^-\pi^0 is consistent with the theoretical
expectation: The constructive interference between electroweak and QCD penguin
diagrams in the mode explains why {\cal B}(B^-\to K^-\pi^0)>{1\over
2}{\cal B}(\ov B^0\to K^-\pi^+). (v) The observation \nc(LL)<3<\nc(LR) and
our preference for \nc(LL)\sim 2 and \nc(LR)\sim 6 are justified by a
recent perturbative QCD calculation of hadronic rare B decays in the heavy
quark limit.Comment: 21 pages; CLEO measurements of several charmless B decay modes are
updated. Discussion of the unitarity angle gamma in the \rho\pi mode is
revise
Soft end-point and mass corrections to the eta' g*g* vertex function
Power-suppressed corrections arising from end-point integration regions to
the space-like vertex function of the massive eta'-meson virtual gluon
transition eta' - g*g* are computed. Calculations are performed within the
standard hard-scattering approach (HSA) and the running coupling method
supplemented by the infrared renormalon calculus. Contributions to the vertex
function from the quark and gluon contents of the eta' -meson are taken into
account and the Borel resummed expressions for F_{eta' g*g*}(Q2,\omega ,\eta),
as well as for F_{eta' g g*}}(Q^{2},\omega =\pm 1,\eta) and F_{eta'
g*g*}(Q^{2},\omega =0,\eta) are obtained. It is demonstrated that the
power-suppressed corrections \sim (\Lambda ^{2}/Q^{2})^{n}, in the explored
range of the total gluon virtuality 1 <Q2 < 25 GeV2, considerably enhance the
vertex function relative to the results found in the framework of the standard
HSA with a fixed coupling. Modifications generated by the eta ' -meson mass
effects are discussed
Experimental Tests of Factorization in Charmless Non-Leptonic Two-Body B Decays
Using a theoretical framework based on the next-to-leading order QCD-improved
effective Hamiltonian and a factorization Ansatz for the hadronic matrix
elements of the four-quark operators, we reassess branching fractions in
two-body non-leptonic decays , involving the lowest lying
light pseudoscalar and vector mesons in the standard model. Using
the sensitivity of the decay rates on the effective number of colors, , as
a criterion of theoretical predictivity, we classify all the current-current
(tree) and penguin transitions in five different classes. The recently measured
charmless two-body decays and charge conjugates) are
dominated by the -stable QCD penguins (class-IV transitions) and their
estimates are consistent with data. The measured charmless and transition ,
on the other hand, belong to the penguin (class-V) and tree (class-III)
transitions. The class-V penguin transitions are in general more difficult to
predict. We propose a number of tests of the factorization framework in terms
of the ratios of branching ratios for some selected decays
involving light hadrons and , which depend only moderately on the
form factors. We also propose a set of measurements to determine the effective
coefficients of the current-current and QCD penguin operators. The potential
impact of decays on the CKM phenomenology is emphasized by
analyzing a number of decay rates in the factorization framework.Comment: 64 pages (LaTex) including 13 figures, requires epsfig.sty; submitted
to Phys. Rev.
Charmless hadronic decays and new physics effects in the general two-Higgs doublet models
Based on the low-energy effective Hamiltonian with the generalized
factorization, we calculate the new physics contributions to the branching
ratios of the two-body charmless hadronic decays of and mesons
induced by the new gluonic and electroweak charged-Higgs penguin diagrams in
the general two-Higgs doublet models (models I, II and III). Within the
considered parameter space, we find that: (a) the new physics effects from new
gluonic penguin diagrams strongly dominate over those from the new -
and - penguin diagrams; (b) in models I and II, new physics contributions
to most studied B meson decay channels are rather small in size: from -15% to
20%; (c) in model III, however, the new physics enhancements to the
penguin-dominated decay modes can be significant, , and
therefore are measurable in forthcoming high precision B experiments; (d) the
new physics enhancements to ratios {\cal B}(B \to K \etap) are significant in
model III, , and hence provide a simple and plausible new
physics interpretation for the observed unexpectedly large B \to K \etap
decay rates; (e) the theoretical predictions for and
in model III are still consistent with the data
within errors; (f) the significant new physics enhancements to the
branching ratios of and decays are helpful to improve the
agreement between the data and the theoretical predictions; (g) the theoretical
predictions of in the 2HDM's are generally
consistent with experimental measurements and upper limits ()Comment: 55 pages, Latex file, 17 PS and EPS figures. With minor corrections,
final version to be published in Phys.Rev. D. Repot-no: PKU-TH-2000-4
Updated Analysis of a_1 and a_2 in Hadronic Two-body Decays of B Mesons
Using the recent experimental data of , , and various model calculations on form
factors, we re-analyze the effective coefficients a_1 and a_2 and their ratio.
QCD and electroweak penguin corrections to a_1 from and
a_2 from are estimated. In addition to the
model-dependent determination, the effective coefficient a_1 is also extracted
in a model-independent way as the decay modes are related by
factorization to the measured semileptonic distribution of at . Moreover, this enables us to extract model-independent
heavy-to-heavy form factors, for example,
and
. The determination of the magnitude of
a_2 from depends on the form factors ,
and at . By requiring that a_2 be
process insensitive (i.e., the value of a_2 extracted from and
states should be similar), as implied by the factorization
hypothesis, we find that form factors are severely constrained;
they respect the relation . Form factors and at
inferred from the measurements of the longitudinal
polarization fraction and the P-wave component in are
obtained. A stringent upper limit on a_2 is derived from the current bound on
\ov B^0\to D^0\pi^0 and it is sensitive to final-state interactions.Comment: 33 pages, 2 figures. Typos in Tables I and IX are corrected. To
appear in Phys. Rev.
Charmless decays using flavor SU(3) symmetry
The decays of mesons to a pair of charmless pseudoscalar () mesons are
analyzed within a framework of flavor SU(3). Symmetry breaking is taken into
account in tree () amplitudes through ratios of decay constants; exact SU(3)
is assumed elsewhere. Acceptable fits to and
branching ratios and CP asymmetries are obtained with tree, color-suppressed
(), penguin (), and electroweak penguin () amplitudes. Crucial
additional terms for describing processes involving and include
a large flavor-singlet penguin amplitude () as proposed earlier and a
penguin amplitude associated with intermediate and quarks. For
the mode a term associated with intermediate
and quarks also may be needed. Values of the weak phase are
obtained consistent with an earlier analysis of decays, where
denotes a vector meson, and with other analyses of CKM parameters.Comment: 26 pages, 1 figure. To be submitted to Phys. Rev. D. Reference
update
Flavor SU(3) Symmetry and Factorization in B Decays to Two Charmless Vector Mesons
We first present a model-independent analysis using flavor SU(3) symmetry
with SU(3) breaking effects in decays to two charmless vector mesons ()
in the final state. In order to bridge the flavor SU(3) symmetry approach and
the factorization approach in decays, we explicitly show how to
translate each SU(3) amplitude into a corresponding amplitude in factorization.
Various decay modes, including which is so far the only mode having some experimental evidence, are discussed in both the SU(3)
symmetry and factorization approaches. Within the generalized factorization
approximation, the flavor SU(3) amplitudes and SU(3) breaking effects are
numerically estimated as a function of the parameter (
the effective number of color).Comment: 15 pages, 1 figure, LaTex file; Corrections to some typos; to be
published in Phys. Rev.
Final-State Phases in Charmed Meson Two-Body Nonleptonic Decays
Observed decay rates indicate large phase differences among the amplitudes
for the charge states in and but
relatively real amplitudes in the charge states for . This
feature is traced using an SU(3) flavor analysis to a sign flip in the
contribution of one of the amplitudes contributing to the latter processes in
comparison with its contribution to the other two sets. This amplitude may be
regarded as an effect of rescattering and is found to be of magnitude
comparable to others contributing to charmed particle two-body nonleptonic
decays.Comment: 19 pages, latex, 4 figures, to be submitted to Phys. Rev.
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