325 research outputs found
The pion quasiparticle in the low-temperature phase of QCD
We extend our previous studies [PhysRevD.90.054509, PhysRevD.92.094510] of
the pion quasiparticle in the low-temperature phase of two-flavor QCD with
support from chiral effective theory. This includes the analysis performed on a
finite temperature ensemble of size at MeV and a
lighter zero-temperature pion mass MeV. Furthermore, we
investigate the Gell-Mann--Oakes-Renner relation at finite temperature and the
Dey-Eletsky-Ioffe mixing theorem at finite quark mass.Comment: 8 pages, 5 figures, talk presented at 35th annual International
Symposium on Lattice Field Theory, 18-24 June 2017, Granada, Spai
Tuning RGD Motif and Hyaluronan Density to Study Integrin Binding
Well-controlled surfaces with immobilized substrates enable novel approaches to investigate specific aspects of biological processes related to cell adhesion or motility. A subset of integrins, cellular transmembrane glycoproteins, recognize the evolutionarily conserved tripeptide sequence RGD, and anchor cells to their surrounding proteins as well as mediate bidirectional signaling. In this study, the main question was how co-presentation of hyaluronan (HA), an essential component of the extracellular matrix (ECM), and the RGD motif affect integrin binding. We report a method to prepare self-assembled monolayers on gold surfaces, co-presenting the cell adhesive RGD motif and small HA molecules, to investigate integrin containing proteoliposome binding. This technique enables an independent adjustment of the RGD motif and HA density while maintaining a passivating background: Layer formation and subsequent interactions with αIIbÎČ3 integrins, which are reconstituted in liposomes, was monitored by label-free quartz crystal microbalance with dissipation monitoring (QCM-D). Exceeding a critical RGD motif density of 40% results in enhanced binding of proteoliposomes. Co-presentation studies with varying HA and constant RGD motif density demonstrate that marginal amounts of HA are sufficient to prevent integrin binding. These findings are of specific importance in relation to cancer cell microenvironments, which show highly enriched HA in the surrounding ECM to reduce adhesion properties
Dynamics, cation conformation and rotamers in guanidinium ionic liquids with ether groups
Ionic liquids are modern materials with a broad range of applications, including electrochemical devices, the exploitation of sustainable resources and chemical processing. Expanding the chemical space to include novel ion classes allows for the elucidation of novel structure-property relationships and fine tuning for specific applications. We prepared a set of ionic liquids based on the sparsely investigated pentamethyl guanidinium cation with a 2-ethoxy-ethyl side chain in combination with a series of frequently used anions. The resulting properties are compared to a cation with a pentyl side chain lacking ether functionalization. We measured the thermal transitions and transport properties to estimate the performance and trends of this cation class. The samples with imide-type anions form liquids at ambient temperature, and show good transport properties, comparable to imidazolium or ammonium ionic liquids. Despite the dynamics being significantly accelerated, ether functionalization of the cation favors the formation of crystalline solids. Single crystal structure analysis, ab initio calculations and variable temperature nuclear magnetic resonance measurements (VT-NMR) revealed that cation conformations for the ether- and alkyl-chain-substituted are different in both the solid and liquid states. While ether containing cations adopt compact, curled structures, those with pentyl side chains are linear. The Eyring plot revealed that the curled conformation is accompanied by a higher activation energy for rotation around the carbon-nitrogen bonds, due to the coordination of the ether chain as observed by VT-NMR
Jet quenching pattern at LHC in PYQUEN model
The first LHC data on high transverse momentum hadron and dijet spectra in
PbPb collisions at center-of-mass energy 2.76 TeV per nucleon pair are analyzed
in the frameworks of PYQUEN jet quenching model. The presented studies for the
nuclear modification factor of high-pT hadrons and the imbalance in dijet
transverse energy support the supposition that the intensive wide-angular
("out-of-cone") medium-induced partonic energy loss is seen in central PbPb
collisions at the LHC.Comment: 5 pages including 4 figures as EPS-files; prepared using LaTeX
package for publication in the European Physical Journal
High Energy Nuclear Collisions: Theory Overview
We review some basic concepts of Relativistic Heavy Ion Physics and discuss
our understanding of some key results from the experimental program at the
Relativistic Heavy Ion Collider (RHIC). We focus in particular on the early
time dynamics of nuclear collisions, some result from lattice QCD, hard probes
and photons.Comment: 11 pages, 3 figures; delivered at ISNP 2009, published in Praman
Jet Reconstruction in Heavy Ion Collisions
We examine the problem of jet reconstruction at heavy-ion colliders using
jet-area-based background subtraction tools as provided by FastJet. We use
Monte Carlo simulations with and without quenching to study the performance of
several jet algorithms, including the option of filtering, under conditions
corresponding to RHIC and LHC collisions. We find that most standard algorithms
perform well, though the anti-kt and filtered Cambridge/Aachen algorithms have
clear advantages in terms of the reconstructed transverse-momentum offset and
dispersion.Comment: 31 pages, 17 figure
Jet Quenching in Heavy Ion Collisions
This review article was prepared for the Landolt-Boernstein volume on
Relativisitc Heavy Ion Physics.Comment: Review articel accepted for publication in the Landolt-Boernstein
Handbook of Physics, ed. R. Stock. 41 pages LaTex, 7 eps-figure
Emerging pharmacotherapy of tinnitus
Tinnitus, the perception of sound in the absence of an auditory stimulus, is perceived by about 1 in 10 adults, and for at least 1 in 100, tinnitus severely affects their quality of life. Because tinnitus is frequently associated with irritability, agitation, stress, insomnia, anxiety and depression, the social and economic burdens of tinnitus can be enormous. No curative treatments are available. However, tinnitus symptoms can be alleviated to some extent. The most widespread management therapies consist of auditory stimulation and cognitive behavioral treatment, aiming at improving habituation and coping strategies. Available clinical trials vary in methodological rigor and have been performed for a considerable number of different drugs. None of the investigated drugs have demonstrated providing replicable long-term reduction of tinnitus impact in the majority of patients in excess of placebo effects. Accordingly, there are no FDA or European Medicines Agency approved drugs for the treatment of tinnitus. However, in spite of the lack of evidence, a large variety of different compounds are prescribed off-label. Therefore, more effective pharmacotherapies for this huge and still growing market are desperately needed and even a drug that produces only a small but significant effect would have an enormous therapeutic impact. This review describes current and emerging pharmacotherapies with current difficulties and limitations. In addition, it provides an estimate of the tinnitus market. Finally, it describes recent advances in the tinnitus field which may help overcome obstacles faced in the pharmacological treatment of tinnitus. These include incomplete knowledge of tinnitus pathophysiology, lack of well-established animal models, heterogeneity of different forms of tinnitus, difficulties in tinnitus assessment and outcome measurement and variability in clinical trial methodology. © 2009 Informa UK Ltd.Fil: Langguth, Berthold. Universitat Regensburg; AlemaniaFil: Salvi, Richard. State University of New York; Estados UnidosFil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Instituto de Investigaciones en IngenierĂa GenĂ©tica y BiologĂa Molecular "Dr. HĂ©ctor N. Torres"; Argentin
Reconstructed Jets at RHIC
To precisely measure jets over a large background such as pile up in high
luminosity p+p collisions at LHC, a new generation of jet reconstruction
algorithms is developed. These algorithms are also applicable to reconstruct
jets in the heavy ion environment where large event multiplicities are
produced. Energy loss in the medium created in heavy ion collisions are already
observed indirectly via inclusive hadron distributions and di-hadron
correlations. Jets can be used to study this energy loss in detail with reduced
biases. We review the latest results on jet-medium interactions as seen in A+A
collisions at RHIC, focusing on the recent progress on jet reconstruction in
heavy ion collisions.Comment: Proceedings for the 26th Winter Workshop on Nuclear Dynamic
A Monte Carlo Model for 'Jet Quenching'
We have developed the Monte Carlo simulation program JEWEL 1.0 (Jet Evolution
With Energy Loss), which interfaces a perturbative final state parton shower
with medium effects occurring in ultra-relativistic heavy ion collisions. This
is done by comparing for each jet fragment the probability of further
perturbative splitting with the density-dependent probability of scattering
with the medium. A simple hadronisation mechanism is included. In the absence
of medium effects, we validate JEWEL against a set of benchmark jet
measurements. For elastic interactions with the medium, we characterise not
only the medium-induced modification of the jet, but also the jet-induced
modification of the medium. Our main physics result is the observation that
collisional and radiative medium modifications lead to characteristic
differences in the jet fragmentation pattern, which persist above a soft
background cut. We argue that this should allow to disentangle collisional and
radiative parton energy loss mechanisms by measuring the n-jet fraction or a
class of jet shape observables.Comment: 16 pages, 10 figures, v2: version accepted by EPJ
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