Systemic inflammation: Cancer's long-distance reach to maximize metastasis

While major improvements have been made in targeting primary tumor growth, metastasis and combating cancer spread remain an enigma. We recently identified a systemic inflammatory cascade involving IL17-producing γδ T cells and neutrophils that advance breast cancer metastasis. These data provide insights into how immune cells promote cancer spread

Hybridized polymer matrix composite

Under certain conditions of combined fire and impact, graphite fibers are released to the atmosphere by graphite fiber composites. The retention of graphite fibers in these situations is investigated. Hybrid combinations of graphite tape and cloth, glass cloth, and resin additives are studied with resin systems. Polyimide resins form the most resistant composites and resins based on simple novolac epoxies the least resistant of those tested. Great improvement in the containment of the fibers is obtained in using graphite/glass hybrids, and nearly complete prevention of individual fiber release is made possible by the use of resin additives

Revving up dendritic cells while braking PD-L1 to jump-start the cancer-immunity cycle motor

Although it is successful for some, most melanoma patients are refractory to T cell checkpoint inhibition. In this issue of Immunity, Merad and colleagues (2016) describe a dendritic-cell-based strategy to heighten the efficacy of therapeutic anti-PD-L1 and BRAF inhibitors in mouse melanoma models

Closed timelike curves in general relativity

Many solutions of Einstein's field equations contain closed timelike curves (CTC). Some of these solutions refer to ordinary materials in situations which might occur in the laboratory, or in astrophysics. It is argued that, in default of a reasonable interpretation of CTC, general relativity does not give a satisfactory account of all phenomena within its terms of reference.Comment: 3 pages, PACS: 042

Conformational Transitions Accompanying Oligomerization of Yeast Alcohol Oxidase, a Peroxisomal Flavoenzyme

Alcohol oxidase (AO) is a homo-octameric flavoenzyme which catalyzes methanol oxidation in methylotrophic yeasts. AO protein is synthesized in the cytosol and subsequently sorted to peroxisomes where the active enzyme is formed. To gain further insight in the molecular mechanisms involved in AO activation, we studied spectroscopically native AO from Hansenula polymorpha and Pichia pastoris and three putative assembly intermediates. Fluorescence studies revealed that both Trp and FAD are suitable intramolecular markers of the conformation and oligomeric state of AO. A direct relationship between dissociation of AO octamers and increase in Trp fluorescence quantum yield and average fluorescence lifetime was found. The time-resolved fluorescence of the FAD cofactor showed a rapid decay component which reflects dynamic quenching due to the presence of aromatic amino acids in the FAD-binding pocket. The analysis of FAD fluorescence lifetime profiles showed a remarkable resemblance of pattern for purified AO and AO present in intact yeast cells. Native AO contains a high content of ordered secondary structure which was reduced upon FAD-removal. Dissociation of octamers into monomers resulted in a conversion of β-sheets into α-helices. Our results are explained in relation to a 3D model of AO, which was built based on the crystallographic data of the homologous enzyme glucose oxidase from Aspergillus niger. The implications of our results for the current model of the in vivo AO assembly pathway are discussed.

An Internet Portal based on 'Twenty Questions'

An efficient Internet portal should contain a search engine or maybe even a decision support system to supply the user with the information (s)he may be looking for. In this report an intelligent agent is suggested that relates different sites to each other, based on the answers supplied by the users looking for certain information. For this purpose a self-learning system has been made, based on the neural network of the game Twenty Questions, but with a strategy that relates different objects or sites by correlating the list of answers to the questions

Traversable wormholes: minimum violation of null energy condition revisited

It was argued in literature that traversable wormholes can exist with arbitrarily small violation of null energy conditions. We show that if the amount of exotic material near the wormhole throat tends to zero, either this leads to a horn instead of a wormhole or the throat approaches the horizon in such a way that infnitely large stresses develop on the throat.Comment: 12 pages. To appear in PR

Endogenous Local Interaction and Multi-Product Firms

Multi-product firms are modeled as endogenously locally interacting entities that gather information on the profitability of product combinations in an environment defined in terms of their currently supplied markets. They learn from their own past play. Local information gathering leads to a greater product diversity relative to global gathering. the introduction of more information at the outset and of finer learning mechanisms leads to ore instability. Cycles show parts of the economy that are in rest, while others are in a state of flux