44 research outputs found
Synthesis and Characterization of Chalcones and Pyrazolines derived from Substituted Aryl ether
Few novel chalcones were synthesised by treating 4-fluoro-3-phenoxy benzaldehyde with different substituted ketones and characterised using 1H NMR and mass spectrometry. The chalcones synthesised were further treated with hydrazine hydrate to get corresponding pyrazolines. The newly synthesised pyrazolines were characterised by 1H NMR and mass spectrometry
2-(2-Methoxyphenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole
In the title molecule, C12H15NO2, the oxazole ring adopts an envelope conformation. Overall, the molecule is approximately planar, the dihedral angle between the mean plane through all but the methylene C atom of the five-membered ring and the aromatic ring being 8.6 (1)°. A weak C—H⋯O interaction contributes to the stabilization of the crystal structure
(2E)-1-(4-Methylphenyl)-3-(2,3,5-trichlorophenyl)prop-2-en-1-one
In the title molecule, C16H11Cl3O, the dihedral angle between the two benzene rings is 33.2 (1)°. The crystal packing is stabilized by C—H⋯O hydrogen bonds
One pot synthesis of some new biologically active arylfurylthiadiazolotriazinones<sup>†</sup>
2690-26934-Amino-6-arylmethyl-3-mercapto-1,2,4-triazin-5(4H)-ones
1 are condensed with 5-aryl-2-furoic acids 2 to yield 7-(5-aryl-2-furyl)-3-arylmethyl-1,3,4-thiadiazolo[2,3-c]-1,2,4-triazin-4(H)-ones
3 employing phosphorus oxychloride as a cyclizing agent in one pot
synthesis. Similarly, 7 -(5-aryl-2-furyl)-3-(t-butyl)-1,3,4-thiadiazolo[2,3-c]-1,2,4-triazin-4(H)-ones
5 have been synthesized. All the newly synthesized
thiadiazolotriazinones 3 and 5 have been tested for their antibacterial
activities against E.coli, S.aureus, P.aeruginosa and B.subtilis and
their MIC values are determined. Compounds 3a-c have been found to be
promising
antibacterial agents
Synthesis and antibacterial properties of nitrofuryltriazolothiadiazepines
3113-3116Methyl aryl ketones 1 on reaction with
5-nitrofurfuraldehyde 2 give l-aryl-3-(5-nitro-2-furyl)-2-propen-1-ones 3
which on bromination affords 2,3-dibromo-1-aryl-3-(5-nitro-2-furyl )-2-propen-1-ones
4. Debromination of 4 by triethylamine in benzene results in 1-aryl-3-(5-nitro-2-furyl)-2-propen-1-ones
5 which on condensation with 3-substituted-4-amino-5-mercapto-1,2,4-triazole 6 furnishes Michael adducts 7. The Michael
adduct 7 undergoes cyclization in conc. sulphuric acid to give 3-aryloxymethyl-6-aryl-8-(5-nitro-2-furyl)-1,2,4-triazolothiadiazepines
8. Antibacterial activity of 7 and 8 has been reported
Synthesis and antibacterial activity of <i style="mso-bidi-font-style:normal">N</i>-bridged heterocycles derived from aryloxymethyltriazoles
1257-1262Reactions of
3-aryloxymethyl-4-amino-5-mercapto-1 ,2,4-triazoles 1 with aromatic
carboxylic acids, furoic acid, oxalic acid, monochloroacetic acid and phenacyl
bromide furnish various N-bridged heterocycles viz., triazolothiadiazoles,
bis-triazolothiadiazoles,
triazolothiadiazinones and triazolothiadiazines.
The structures of these N-bridged heterocycles are characterized on
the basis of elemental analyses, IR, NMR and mass spectral data. Some of these compounds
are also subjected to antibacterial screening studies
Synthesis of some new biologically active triazino-thiadiazinones
475-478A series of 4H, 8H-1,2,4-triazino[3,4-b]-1,3,4-thiadiazin-4-ones
3a-i have been synthesized by the reaction of 4-amino-6-substituted-3-mercapto-1
,2,4-triazin-5(4H)-ones 1 with substituted phenacyl bromides 2.
These newly synthesized compounds have been tested for antimicrobial activities
Synthesis and biological activity of some bis-triazole derivatives<sup>+</sup>
2010-2014A series of
bis-(4-amino-5-mercapto-triazol-3-yl)alkanes, their Schiff bases and
bis-(1,2,4-triazolo[3,4-b]-1,3,4-thiadiazol-4-yl)alkanes have been
synthesized. The newly synthesized compounds have been screened for their
antibacterial properties.Compounds 5h and 9f exhibit greater
degree of antibacterial activity than the standard, Furacin